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Life after the thymus: CD31+ and CD31− human naive CD4+ T-cell subsets
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Early in life, thymic export establishes the size and the diversity of the human naive T-cell pool. Yet, on puberty thymic activity drastically decreases. Because the overall size of the naive T-cell pool decreases only marginally during ageing, peripheral postthymic expansion of naive T cells has been postulated to account partly for the maintenance of T-cell immunity in adults. So far, the analysis of these processes had been hampered by the inability to distinguish recent thymic emigrants from proliferated, peripheral, naive T cells. However, recently, CD31 has been introduced as a marker to distinguish 2 subsets of naive CD4+ T cells with distinct T-cell receptor excision circle (TREC) content in the peripheral blood of healthy humans. Here, we review studies that have characterized TREChi CD31+ thymicnaive CD4+ T cells and have accordingly used the assessment of this distinct subset of naive CD4+ T cells as a correlate of thymic activity. We will discuss further potential clinical applications and how more research on CD31+ thymicnaive and CD31− centralnaive CD4+ T cells may foster our knowledge of the impact of thymic involution on immune competence.
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“Lymphopenia leads to an increase in the homeostatic proliferation of naive T cells, which is usually not sufficient to keep their number constant [332, 333].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [332]
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“This setting of partial lymphopenia results in increasing naive T-cell homeostatic proliferation, although this is not sufficient to maintain a constant number of these cells [77, 78].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [77]
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Metadata
- Authors
- Kohler, S., & Thiel, A.
- Affiliations
- Clinical Immunology Group, Deutsches Rheuma-Forschungszentrum Berlin, Berlin; and
- German Rheumatism Research Centre (DE)
- ORCID
- Thiel, Andreas
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2009-01-22
- Volume
- 113
- Issue
- 4
- Pages
- 769-774
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1999924197
- Cited by
- 307
- References
- 75
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 12 · 2023: 6 · 2022: 11 · 2021: 25 · 2020: 18 · 2019: 23 · 2018: 21 · 2017: 18 · 2016: 24 · 2015: 21 · 2014: 25 · 2013: 23 · 2012: 18
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Keywords
- CD31, naive CD4+ T cells, thymic emigrants, thymic involution, TREC, T cell receptor diversity, immunosenescence, T cell subsets
- MeSH terms
- Animals, Homeostasis, Humans, Immunity, Innate, Thymus Gland, CD4-Positive T-Lymphocytes, Platelet Endothelial Cell Adhesion Molecule-1, Cell Proliferation
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