The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
High plasma levels of soluble P-selectin are predictive of venous thromboembolism in cancer patients: results from the Vienna Cancer and Thrombosis Study (CATS)
Abstract
Cancer patients are at high risk for venous thromboembolism (VTE). Laboratory parameters with a predictive value for VTE could help stratify patients into high- or low-risk groups. The cell adhesion molecule P-selectin was recently identified as risk factor for VTE. To investigate soluble P-selectin (sP-selectin) in cancer patients as risk predictor for VTE, we performed a prospective cohort study of 687 cancer patients and followed them for a median (IQR) of 415 (221-722) days. Main tumor entities were malignancies of the breast (n = 125), lung (n = 86), gastrointestinal tract (n = 130), pancreas (n = 42), kidney (n = 19), prostate (n = 72), and brain (n = 80); 91 had hematologic malignancies; 42 had other tumors. VTE occurred in 44 (6.4%) patients. In multivariable analysis, elevated sP-selectin (cutoff level, 53.1 ng/mL, 75th percentile of study population) was a statistically significant risk factor for VTE after adjustment for age, sex, surgery, chemotherapy, and radiotherapy (hazard ratio = 2.6, 95% confidence interval, 1.4-4.9, P = .003). The cumulative probability of VTE after 6 months was 11.9% in patients with sP-selectin above and 3.7% in those below the 75th percentile (P = .002). High sP-selectin plasma levels independently predict VTE in cancer patients. Measurement of sP-selectin at diagnosis of cancer could help identify patients at increased risk for VTE.
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Cites
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Cited by
Epidemiology of cancer-associated venous thrombosis
Timp, J. F., Braekkan, S. K., Versteeg, H. H., & Cannegieter, S. C. (2013) · Blood · doi:10.1182/blood-2013-04-460121 · Cited by 1,205
Prediction of venous thromboembolism in cancer patients
Ay, C., Dunkler, D., Marosi, C., Chiriac, A.-L., Vormittag, R., Simanek, R., Quehenberger, P., Zielinski, C., & Pabinger, I. (2010) · Blood · doi:10.1182/blood-2010-02-270116 · Cited by 772
Self-citationAy, C., Vormittag, R., Dunkler, D., Simanek, R., Chiriac, A.-L., Drach, J., Quehenberger, P., Wagner, O., Zielinski, C., & Pabinger, I. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.21.7752 · Cited by 422
Self-citationTHALER, J., AY, C., MACKMAN, N., BERTINA, R. M., KAIDER, A., MAROSI, C., KEY, N. S., BARCEL, D. A., SCHEITHAUER, W., KORNEK, G., et al. (2012) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2012.04754.x · Cited by 274
Self-citationBiomarkers for prediction of venous thromboembolism in cancer
Pabinger, I., Thaler, J., & Ay, C. (2013) · Blood · doi:10.1182/blood-2013-04-460147 · Cited by 256
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Metadata
- Authors
- Ay, C., Simanek, R., Vormittag, R., Dunkler, D., Alguel, G., Koder, S., Kornek, G., Marosi, C., Wagner, O., Zielinski, C., & Pabinger, I.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2008-10-01
- Volume
- 112
- Issue
- 7
- Pages
- 2703-2708
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2007208430
- Cited by
- 422
- References
- 48
- FWCI
- 12.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ay, C., Simanek, R., Vormittag, R., Dunkler, D., Alguel, G., Koder, S., Kornek, G., Marosi, C., Wagner, O., Zielinski, C., & Pabinger, I. (2008). High plasma levels of soluble P-selectin are predictive of venous thromboembolism in cancer patients: results from the Vienna Cancer and Thrombosis Study (CATS). Blood. https://doi.org/10.1182/blood-2008-02-142422
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