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Solid cancers after allogeneic hematopoietic cell transplantation

Rizzo, J. Douglas, Curtis, Rochelle E., Socié, Gérard, Sobocinski, Kathleen A., Gilbert, Ethel, Landgren, Ola, Travis, Lois B., Travis, William D., Flowers, Mary E. D., Friedman, Debra L., Horowitz, Mary M., Wingard, John R., Deeg, H. Joachim·2009·Blood
DOI 10.1182/blood-2008-05-158782
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Abstract

Transplant recipients have been reported to have an increased risk of solid cancers but most studies are small and have limited ability to evaluate the interaction of host, disease, and treatment-related factors. In the largest study to date to evaluate risk factors for solid cancers, we studied a multi-institutional cohort of 28 874 allogeneic transplant recipients with 189 solid malignancies. Overall, patients developed new solid cancers at twice the rate expected based on general population rates (observed-to-expected ratio 2.1; 95% confidence interval 1.8-2.5), with the risk increasing over time (P trend < .001); the risk reached 3-fold among patients followed for 15 years or more after transplantation. New findings showed that the risk of developing a non–squamous cell carcinoma (non-SCC) following conditioning radiation was highly dependent on age at exposure. Among patients irradiated at ages under 30 years, the relative risk of non-SCC was 9 times that of nonirradiated patients, while the comparable risk for older patients was 1.1 (P interaction < .01). Chronic graft-versus-host disease and male sex were the main determinants for risk of SCC. These data indicate that allogeneic transplant survivors, particularly those irradiated at young ages, face increased risks of solid cancers, supporting strategies to promote lifelong surveillance among these patients.

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Metadata

Authors
Rizzo, J. D., Curtis, R. E., Socié, G., Sobocinski, K. A., Gilbert, E., Landgren, O., Travis, L. B., Travis, W. D., Flowers, M. E. D., Friedman, D. L., Horowitz, M. M., Wingard, J. R., & Deeg, H. J.
Affiliations
  • Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee;
  • Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD;
  • Hôpital Saint Louis, Paris, France;
  • James P. Willmot Cancer Center, Rochester, NY;
  • Memorial Sloan-Kettering Cancer Center, New York, NY;
  • Fred Hutchinson Cancer Research Center, Seattle, WA; and
  • Shands Hospital, Gainesville, FL
Venue
Blood
Publisher
American Society of Hematology
Published
2009-01-29
Volume
113
Issue
5
Pages
1175-1183
ISSN
  • 0006-4971
  • 1528-0020
DOI
10.1182/blood-2008-05-158782
Cited by
439
References
2
Language
en

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CoChat. (2026). Citation check: Solid cancers after allogeneic hematopoietic cell transplantation. https://app.cochat.ai/papers/10.1182/blood-2008-05-158782
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Rizzo, J. D., Curtis, R. E., Socié, G., Sobocinski, K. A., Gilbert, E., Landgren, O., Travis, L. B., Travis, W. D., Flowers, M. E. D., Friedman, D. L., Horowitz, M. M., Wingard, J. R., & Deeg, H. J. (2009). Solid cancers after allogeneic hematopoietic cell transplantation. Blood. https://doi.org/10.1182/blood-2008-05-158782