The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCβ2 axis
Open accessAbstract
Homing of endothelial progenitor cells (EPCs) to the neovascular zone is now considered to be an essential step in the formation of vascular networks during embryonic development and also for neovascularization in postnatal life. We report here the prominent role of the insulin-like growth factor 2 (IGF2)/IGF2 receptor (IGF2R) system in promoting EPC homing. With high-level expression of IGF2R in EPCs, IGF2-induced hypoxic conditions stimulated multiple steps of EPC homing in vitro and promoted both EPC recruitment and incorporation into the neovascular area, resulting in enhanced angiogenesis in vivo. Remarkably, all IGF2 actions were exerted predominantly through IGF2R-linked G(i) protein signaling and required intracellular Ca2+ mobilization induced by the β2 isoform of phospholipase C. Together, these findings indicate that locally generated IGF2 at either ischemic or tumor sites may contribute to postnatal vasculogenesis by augmenting the recruitment of EPCs. The utilization of the IGF2/IGF2R system may therefore be useful for the development of novel means to treat angiogenesis-dependent diseases.
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Cites
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
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Targeting HIF-1 for cancer therapy
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Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
Ceradini, D. J., Kulkarni, A. R., Callaghan, M. J., Tepper, O. M., Bastidas, N., Kleinman, M. E., Capla, J. M., Galiano, R. D., Levine, J. P., & Gurtner, G. C. (2004) · Nature Medicine · doi:10.1038/nm1075 · Cited by 2,600
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Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis
Gao, D., Nolan, D. J., Mellick, A. S., Bambino, K., McDonnell, K., & Mittal, V. (2008) · Science · doi:10.1126/science.1150224 · Cited by 632
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Demidova-Rice, T. N., Hamblin, M. R., & Herman, I. M. (2012) · Advances in Skin & Wound Care · doi:10.1097/01.asw.0000416006.55218.d0 · Cited by 721
Stem Cells and Cell Therapies in Lung Biology and Lung Diseases
Weiss, D. J., Kolls, J. K., Ortiz, L. A., Panoskaltsis-Mortari, A., & Prockop, D. J. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200804-037dw · Cited by 309
Postischemic Revascularization: From Cellular and Molecular Mechanisms to Clinical Applications
Silvestre, J.-S., Smadja, D. M., & Lévy, B. I. (2013) · Physiological Reviews · doi:10.1152/physrev.00006.2013 · Cited by 255
Reduction of both number and proliferative activity of human endothelial progenitor cells in obesity
Tobler, K., Freudenthaler, A., Baumgartner-Parzer, S. M., Wolzt, M., Ludvik, B., Nansalmaa, E., Nowotny, P. J., Seidinger, D., Steiner, S., Luger, A., et al. (2010) · International Journal of Obesity · doi:10.1038/ijo.2009.280 · Cited by 59
Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence
Alessio, N., Squillaro, T., Di Bernardo, G., Galano, G., De Rosa, R., Melone, M. A., Peluso, G., & Galderisi, U. (2020) · eLife · doi:10.7554/elife.54523 · Cited by 51
Metadata
- Authors
- Maeng, Y.-S., Choi, H.-J., Kwon, J.-Y., Park, Y.-W., Choi, K.-S., Min, J.-K., Kim, Y.-H., Suh, P.-G., Kang, K.-S., Won, M.-H., Kim, Y.-M., & Kwon, Y.-G.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2009-01-01
- Volume
- 113
- Issue
- 1
- Pages
- 233-243
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2042028039
- Cited by
- 158
- References
- 6
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Maeng, Y.-S., Choi, H.-J., Kwon, J.-Y., Park, Y.-W., Choi, K.-S., Min, J.-K., Kim, Y.-H., Suh, P.-G., Kang, K.-S., Won, M.-H., Kim, Y.-M., & Kwon, Y.-G. (2009). Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCβ2 axis. Blood. https://doi.org/10.1182/blood-2008-06-162891
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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