The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Restoration of NET formation by gene therapy in CGD controls aspergillosis
Open accessAbstract
Chronic granulomatous disease (CGD) patients have impaired nicotinamide adenine dinucleotide phosphate (NADPH) oxidase function, resulting in poor antimicrobial activity of neutrophils, including the inability to generate neutrophil extracellular traps (NETs). Invasive aspergillosis is the leading cause of death in patients with CGD; it is unclear how neutrophils control Aspergillus species in healthy persons. The aim of this study was to determine whether gene therapy restores NET formation in CGD by complementation of NADPH oxidase function, and whether NETs have antimicrobial activity against Aspergillus nidulans. Here we show that reconstitution of NET formation by gene therapy in a patient with CGD restores neutrophil elimination of A nidulans conidia and hyphae and is associated with rapid cure of preexisting therapy refractory invasive pulmonary aspergillosis, underlining the role of functional NADPH oxidase in NET formation and antifungal activity.
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Cites
Neutrophil Extracellular Traps Kill Bacteria
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Self-citationNovel cell death program leads to neutrophil extracellular traps
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Self-citationAspergillus fumigatus and Aspergillosis
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Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
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Self-citationNeutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms
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Cited by
Neutrophil extracellular traps in immunity and disease
Papayannopoulos, V. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.105 · Cited by 3,397
Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps
Papayannopoulos, V., Metzler, K. D., Hakkim, A., & Zychlinsky, A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201006052 · Cited by 2,103
Self-citationThrombosis as an intravascular effector of innate immunity
Engelmann, B., & Massberg, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3345 · Cited by 1,989
Lood, C., Blanco, L. P., Purmalek, M. M., Carmona-Rivera, C., De Ravin, S. S., Smith, C. K., Malech, H. L., Ledbetter, J. A., Elkon, K. B., & Kaplan, M. J. (2016) · Nature Medicine · doi:10.1038/nm.4027 · Cited by 1,570
PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps
Li, P., Li, M., Lindberg, M. R., Kennett, M. J., Xiong, N., & Wang, Y. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100239 · Cited by 1,495
Metadata
- Authors
- Bianchi, M., Hakkim, A., Brinkmann, V., Siler, U., Seger, R. A., Zychlinsky, A., & Reichenbach, J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2009-09-24
- Volume
- 114
- Issue
- 13
- Pages
- 2619-2622
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2073676586
- Cited by
- 593
- References
- 24
- FWCI
- 12.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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