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Cited by 294

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Allo-HLA reactivity of virus-specific memory T cells is common

Open access
Amir, Avital L., D'Orsogna, Lloyd J. A., Roelen, Dave L., van Loenen, Marleen M., Hagedoorn, Renate S., de Boer, Renate, van der Hoorn, Menno A. W. G., Kester, Michel G. D., Doxiadis, Ilias I. N., Falkenburg, J. H. Frederik, Claas, Frans H. J., Heemskerk, Mirjam H. M.·2010·Blood
DOI 10.1182/blood-2009-07-234906
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Abstract

Graft-versus-host disease and graft rejection are major complications of allogeneic HLA-mismatched stem cell transplantation or organ transplantation that are caused by alloreactive T cells. Because a range of acute viral infections have been linked to initiating these complications, we hypothesized that the cross-reactive potential of virus-specific memory T cells to allogeneic (allo) HLA molecules may be able to mediate these complications. To analyze the allo-HLA reactivity, T cells specific for Epstein-Barr virus, cytomegalovirus, varicella zoster virus, and influenza virus were tested against a panel of HLA-typed target cells, and target cells transduced with single HLA molecules. Eighty percent of T-cell lines and 45% of virus-specific T-cell clones were shown to cross-react against allo-HLA molecules. The cross-reactivity of the CD8 and CD4 T-cell clones was directed primarily against HLA class I and II, respectively. However, a restricted number of CD8 T cells exhibited cross-reactivity to HLA class II. T-cell receptor (TCR) gene transfer confirmed that allo-HLA reactivity and virus specificity were mediated via the same TCR. These results demonstrate that a substantial proportion of virus-specific T cells exert allo-HLA reactivity, which may have important clinical implications in transplantation settings as well as adoptive transfer of third-party virus-specific T cells.

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Metadata

Authors
Amir, A. L., D'Orsogna, L. J. A., Roelen, D. L., van Loenen, M. M., Hagedoorn, R. S., de Boer, R., van der Hoorn, M. A. W. G., Kester, M. G. D., Doxiadis, I. I. N., Falkenburg, J. H. F., Claas, F. H. J., & Heemskerk, M. H. M.
Venue
Blood
Publisher
American Society of Hematology
Published
2010-04-15
Volume
115
Issue
15
Pages
3146-3157
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood-2009-07-234906
OpenAlex
W2076125315
Cited by
294
References
35
FWCI
11.01
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Allo-HLA reactivity of virus-specific memory T cells is common. https://app.cochat.ai/papers/10.1182/blood-2009-07-234906
The paper
Amir, A. L., D'Orsogna, L. J. A., Roelen, D. L., van Loenen, M. M., Hagedoorn, R. S., de Boer, R., van der Hoorn, M. A. W. G., Kester, M. G. D., Doxiadis, I. I. N., Falkenburg, J. H. F., Claas, F. H. J., & Heemskerk, M. H. M. (2010). Allo-HLA reactivity of virus-specific memory T cells is common. Blood. https://doi.org/10.1182/blood-2009-07-234906

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.