The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia
Open accessAbstract
Transcription factor CCAAT enhancer binding protein α (C/EBPα) is essential for granulopoiesis and its function is deregulated in leukemia. Inhibition of E2F1, the master regulator of cell-cycle progression, by C/EBPα is pivotal for granulopoiesis. Recent studies show microRNA-223 (miR-223), a transcriptional target of C/EBPα, as a critical player during granulopoiesis. In this report, we demonstrate that during granulopoiesis microRNA-223 targets E2F1. E2F1 protein was up-regulated in miR-223 null mice. We show that miR-223 blocks cell-cycle progression in myeloid cells. miR-223 is down-regulated in different subtypes of acute myeloid leukemia (AML). We further show that E2F1 binds to the miR-223 promoter in AML blast cells and inhibits miR-223 transcription, suggesting that E2F1 is a transcriptional repressor of the miR-223 gene in AML. Our study supports a molecular network involving miR-223, C/EBPα, and E2F1 as major components of the granulocyte differentiation program, which is deregulated in AML.
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Cites
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Self-citationCCAAT-Enhancer Binding Protein: A Component of a Differentiation Switch
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Vickers, K. C., Palmisano, B. T., Shoucri, B. M., Shamburek, R. D., & Remaley, A. T. (2011) · Nature Cell Biology · doi:10.1038/ncb2210 · Cited by 2,741
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Metadata
- Authors
- Pulikkan, J. A., Dengler, V., Peramangalam, P. S., Peer Zada, A. A., Müller-Tidow, C., Bohlander, S. K., Tenen, D. G., & Behre, G.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2010-03-04
- Volume
- 115
- Issue
- 9
- Pages
- 1768-1778
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2079625864
- Cited by
- 285
- References
- 7
- FWCI
- 12.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia. https://app.cochat.ai/papers/10.1182/blood-2009-08-240101
- The paper
- Pulikkan, J. A., Dengler, V., Peramangalam, P. S., Peer Zada, A. A., Müller-Tidow, C., Bohlander, S. K., Tenen, D. G., & Behre, G. (2010). Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia. Blood. https://doi.org/10.1182/blood-2009-08-240101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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