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Identification and functional analysis of endothelial tip cell–enriched genes
Open accessAbstract
Sprouting of developing blood vessels is mediated by specialized motile endothelial cells localized at the tips of growing capillaries. Following behind the tip cells, endothelial stalk cells form the capillary lumen and proliferate. Expression of the Notch ligand Delta-like-4 (Dll4) in tip cells suppresses tip cell fate in neighboring stalk cells via Notch signaling. In DLL4+/− mouse mutants, most retinal endothelial cells display morphologic features of tip cells. We hypothesized that these mouse mutants could be used to isolate tip cells and so to determine their genetic repertoire. Using transcriptome analysis of retinal endothelial cells isolated from DLL4+/− and wild-type mice, we identified 3 clusters of tip cell–enriched genes, encoding extracellular matrix degrading enzymes, basement membrane components, and secreted molecules. Secreted molecules endothelial-specific molecule 1, angiopoietin 2, and apelin bind to cognate receptors on endothelial stalk cells. Knockout mice and zebrafish morpholino knockdown of apelin showed delayed angiogenesis and reduced proliferation of stalk cells expressing the apelin receptor APJ. Thus, tip cells may regulate angiogenesis via matrix remodeling, production of basement membrane, and release of secreted molecules, some of which regulate stalk cell behavior.
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“Integrins, which regulate endothelial cell–cell and cell–matrix interactions, have been identified as alternative receptors for the angiopoietins in certain Tie2-negative non-endothelial cells22232425, and in the endothelial tip cells of angiogenic vessel sprouts, which express low levels of Tie2 (refs 26, 27).”
From Endothelial destabilization by angiopoietin-2 via integrin β1 activation (2015) · cites this paper as [26]
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Cites
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) · Science · doi:10.1126/science.277.5322.55 · Cited by 3,570
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302047 · Cited by 2,894
Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor
Tatemoto, K., Hosoya, M., Habata, Y., Fujii, R., Kakegawa, T., Zou, M.-X., Kawamata, Y., Fukusumi, S., Hinuma, S., Kitada, C., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9489 · Cited by 1,684
Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system
Augustin, H. G., Koh, G. Y., Thurston, G., & Alitalo, K. K. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2639 · Cited by 1,512
multifunctional enzymes in cancer
Mohamed, M. M., & Sloane, B. F. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1949 · Cited by 1,303
uPAR: a versatile signalling orchestrator
Blasi, F., & Carmeliet, P. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm977 · Cited by 1,224
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
Noguera‐Troise, I., Daly, C., Papadopoulos, N. J., Coetzee, S., Boland, P., Gale, N. W., Lin, H. C., Yancopoulos, G. D., & Thurston, G. (2006) · Nature · doi:10.1038/nature05355 · Cited by 1,032
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
Ridgway, J., Zhang, G., Wu, Y., Stawicki, S., Liang, W.-C., Chanthery, Y., Kowalski, J., Watts, R. J., Callahan, C., Kasman, I., et al. (2006) · Nature · doi:10.1038/nature05313 · Cited by 986
Suchting, S., Freitas, C., le Noble, F. A. C., Benedito, R., Bréant, C., Duarte, A., & Eichmann, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611177104 · Cited by 846
Self-citationBlocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
Tammela, T., Zarkada, G., Wallgard, E., Murtomäki, A., Suchting, S., Wirzenius, M., Waltari, M., Hellström, M., Schomber, T., Peltonen, R., et al. (2008) · Nature · doi:10.1038/nature07083 · Cited by 834
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Weinstein, N., Mendoza, L., & Alvarez-Buylla, E. R. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00040 · Cited by 40
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Stepanova, D., Byrne, H. M., Maini, P. K., & Alarcón, T. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008055 · Cited by 39
Weinstein, N., Mendoza, L., Gitler, I., & Klapp, J. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00960 · Cited by 38
SCF/c-Kit-activated signaling and angiogenesis require Gαi1 and Gαi3
Shan, H., Jiang, K. P., Zhao, M.-Z., Deng, W.-J., Cao, W.-H., Li, J.-J., Li, K., She, C., Luo, W.-F., Yao, J., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.82855 · Cited by 37
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Kocijan, T., Rehman, M., Colliva, A., Groppa, E., Leban, M., Vodret, S., Volf, N., Zucca, G., Cappelletto, A., Piperno, G. M., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa012 · Cited by 38
Plasma membrane translocation of REDD1 governed by GPCRs contributes to mTORC1 activation
Michel, G., Matthes, H. W. D., Hachet‐Haas, M., Baghdadi, K. E., Mey, J. D., Pepperkok, R., Simpson, J. C., Galzi, J., & Lecat, S. (2013) · Journal of Cell Science · doi:10.1242/jcs.136432 · Cited by 36
Koon, Y. L., Zhang, S., Rahmat, M. B. B., Koh, C.-G., & Chiam, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-27645-1 · Cited by 36
BMP9 signaling promotes the normalization of tumor blood vessels
Viallard, C., Audiger, C., Popović, N., Akla, N., Lanthier, K., Legault-Navarrete, I., Melichar, H. J., Costantino, S., Lesage, S., & Larrivée, B. (2020) · Oncogene · doi:10.1038/s41388-020-1200-0 · Cited by 36
The protease MT1‐MMP drives a combinatorial proteolytic program in activated endothelial cells
Kozioł, A., Gonzalo, P., Mota, A., Pollán, Á., Lorenzo, C., Colomé, N., Montaner, D. A., Dopazo, J., Arribas, J., Canals, F., et al. (2012) · The FASEB Journal · doi:10.1096/fj.12-205906 · Cited by 35
Gengenbacher, N., Singhal, M., Mogler, C., Hai, L., Milde, L., Pari, A. A. A., Besemfelder, E., Fricke, C., Baumann, D., Gehrs, S., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0122 · Cited by 36
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Paskaradevan, S., & Scott, I. C. (2012) · Biology Open · doi:10.1242/bio.2012380 · Cited by 33
Nedvetsky, P. I., Zhao, X., Mathivet, T., Aspalter, I. M., Stanchi, F., Metzger, R. J., Mostov, K. E., & Gerhardt, H. (2016) · Development · doi:10.1242/dev.134767 · Cited by 33
Self-citationDeckelbaum, R. A., Lobov, I. B., Cheung, E., Halász, G., Rajamani, S., Lerner, J. L., Tong, C., Li, Z., Boland, P. S., Dominguez, M. G., et al. (2019) · Angiogenesis · doi:10.1007/s10456-019-09696-8 · Cited by 34
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Matsuo, E., Okamoto, T., Ito, A., Kawamoto, E., Asanuma, K., Wada, K., Shimaoka, M., Takao, M., & Shimamoto, A. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112835 · Cited by 33
Yao, M., Jiang, Q. L., Ma, Y., Zhu, Y., Zhang, Q., Shi, Z.-H., Zhao, C., & Yan, B. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.01.012 · Cited by 33
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Matsubara, T., Iga, T., Sugiura, Y., Kusumoto, D., Sanosaka, T., Tai-Nagara, I., Takeda, N., Fong, G., Ito, K., Ema, M., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20211789 · Cited by 33
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Lai, L., Hennessey, J., Bares, V., Son, E., Ban, Y. J., Wang, W., Qi, J., Jiang, G., Liberzon, A., & Ge, X. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/082511 · Cited by 31
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Liang, J. H., Akhanov, V., Ho, A., Tawfik, M., D’Souza, S. P., Cameron, M. A., Lang, R. A., & Samuel, M. A. (2023) · Current Biology · doi:10.1016/j.cub.2023.07.040 · Cited by 31
Vázquez-Liébanas, E., Mocci, G., Li, W., Laviña, B., Reddy, A., O’Connor, C., Hudson, N., Elbeck, Z., Nikoloudis, I., Gaengel, K., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113911 · Cited by 32
Palm, M. M., Dallinga, M. G., van Dijk, E., Klaassen, I., Schlingemann, R. O., & Merks, R. M. H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159478 · Cited by 36
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Yang, C., Gibson, V. P., & Hardy, P. (2022) · Cells · doi:10.3390/cells11101670 · Cited by 31
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Mühleder, S., Fuchs, C., Basílio, J., Szwarc, D., Pill, K., Labuda, K., Slezak, P., Siehs, C., Pröll, J., Priglinger, E., et al. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03213-2 · Cited by 31
Margadant, C. (2020) · Angiogenesis · doi:10.1007/s10456-020-09706-0 · Cited by 29
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Kraft, M., Schoofs, H., Petkova, M., Andrade, J., Grosso, A. R., Benedito, R., De Roo, A.-K., Boon, L. M., Vikkula, M., Kapp, F. G., et al. (2025) · Nature Cardiovascular Research · doi:10.1038/s44161-025-00655-9 · Cited by 28
Kurkalang, S., Roy, S., Acharya, A., Mazumder, P., Mazumder, S., Patra, S., Ghosh, S., Sarkar, S., Kundu, S., Biswas, N. K., et al. (2023) · Cancer Science · doi:10.1111/cas.15979 · Cited by 28
Zhou, Y., Tabib, T., Huang, M., Yuan, K., Kim, Y., Morse, C., Sembrat, J., Valenzi, E., & Lafyatis, R. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.320005 · Cited by 31
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Xu, H., Pumiglia, K. M., & LaFlamme, S. E. (2020) · Journal of Cell Science · doi:10.1242/jcs.246595 · Cited by 28
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Pietilä, R. S., Nätynki, M., Tammela, T., Kangas, J., Pulkki, K. H., Limaye, N., Vikkula, M., Koh, G. Y., Saharinen, P., Alitalo, K. K., et al. (2012) · Journal of Cell Science · doi:10.1242/jcs.098020 · Cited by 28
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Galeano-Otero, I., Toro, R. D., Khatib, A., Rosado, J. A., Ordóñez, A., & Smani, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.639952 · Cited by 27
Zhou, X., Pucel, J. C., Nomura-Kitabayashi, A., Chandakkar, P., Bartoletti, A. P., Jhangiani, N. L., Bao, D., Fan, J., Arthur, H. M., Ullmer, C., et al. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.319385 · Cited by 24
Cai, L., Leng, Z. G., Guo, Y., Lin, S., Wu, Z. R., Su, Z. P., Lu, J. L., Wei, L. F., Zhuge, Q. C., Jin, K., et al. (2015) · Endocrine · doi:10.1007/s12020-015-0824-2 · Cited by 27
Shirazi, S. P., Negretti, N. M., Jetter, C. S., Sharkey, A. L., Garg, S., Kapp, M., Wilkins, D. J., Fortier, G., Mallapragada, S., Banovich, N. E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60371-7 · Cited by 33
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Hara, C., Kasai, A., Gomi, F., Satooka, T., Sakimoto, S., Nakai, K., Yoshioka, Y., Yamamuro, A., Maeda, S., & Nishida, K. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-11611 · Cited by 29
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Yu, P., Chou, S.-F., Chen, C., Hung, H., Lai, C.-Y., Yang, P., Jeng, Y., Liaw, S.-F., Kuo, H.-H., Hsu, H., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082254 · Cited by 25
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Pan, K., Yang, Y., Lee, W.-J., Hua, K., & Chien, M. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188672 · Cited by 24
Yoodee, S., Peerapen, P., Plumworasawat, S., & Thongboonkerd, V. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.02.218 · Cited by 23
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Haddad, G., Zhabyeyev, P., Farhan, M., Zhu, L. F., Kassiri, Z., Rayner, D. C., Vanhaesebroeck, B., Oudit, G. Y., & Murray, A. G. (2014) · Blood · doi:10.1182/blood-2014-02-557975 · Cited by 23
Nikmaneshi, M. R., Firoozabadi, B., Mozafari, A., & Munn, L. L. (2020) · Scientific Reports · doi:10.1038/s41598-020-59658-0 · Cited by 23
Regensburger, D., Tenkerian, C., Pürzer, V., Schmid, B., Wohlfahrt, T., Stolzer, I., López-Posadas, R., Günther, C., Waldner, M. J., Becker, C., et al. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa346 · Cited by 22
Guo, Y., Li, J., Zhang, H., Zi, H., Liu, M., An, Q., Qiu, T., Li, P., Song, J., Liu, P., et al. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae186 · Cited by 27
Sturtzel, C., Testori, J., Schweighofer, B., Bilban, M., & Hofer, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101521 · Cited by 22
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Ma, J., Évrard, S., Badiola, I., Siegfried, G., & Khatib, A. (2017) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2017.06.001 · Cited by 20
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Yang, H. H., Wang, X., Sun, J., Liu, C., Li, G., Zhu, J., & Huang, J. (2021) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmab039 · Cited by 21
Kim, J., Lee, H., & Jin, S. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303219 · Cited by 21
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Hasan, S. S., John, D., Rudnicki, M., AlZaim, I., Eberhard, D., Moll, I., Taylor, J., Klein, C., von Heesen, M., Conradi, L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60910-2 · Cited by 20
Gross, D. A., Cheng, H. S., Zhuang, R., McCoy, M. G., Pérez‐Cremades, D., Salyers, Z. R., Wara, A. K., Haemmig, S., RYAN, T. E., & Feinberg, M. W. (2021) · JCI Insight · doi:10.1172/jci.insight.150761 · Cited by 20
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Nikmaneshi, M. R., Jain, R. K., & Munn, L. L. (2023) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1011131 · Cited by 22
Zhang, S., Li, H., Li, B., Zhong, D., Gu, X., Tang, L., Wang, Y., Wang, C., Zhou, R., Li, Y., et al. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-17202 · Cited by 20
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Yang, H., Fang, L., Zhan, R., Hegarty, J. M., Ren, J., Hsiai, T. K., Gleeson, J. G., Miller, Y. I., Trejo, J., & Chi, N. C. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.05.011 · Cited by 20
Azad, A. K., Zhabyeyev, P., Vanhaesebroeck, B., Eitzen, G., Oudit, G. Y., Moore, R. B., & Murray, A. G. (2020) · Oncogene · doi:10.1038/s41388-020-01444-3 · Cited by 19
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Xu, J., Shi, C., Ding, Y., Qin, T., Li, C., Yuan, F., Liu, Y., Xie, Y., Qin, Y., Cao, Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202406398 · Cited by 18
Zhang, Y., Wei, H., Nouws, J., Jiang, W., Brewster, R., Nguyen, J., Liang, S., Pass, S. M., Wang, W., Collin, F., et al. (2026) · Nature Genetics · doi:10.1038/s41588-025-02480-z · Cited by 24
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Kang, N., Liang, X. Y., Fan, B., Zhao, C., Shen, B., Ji, X., & Liu, Y. (2022) · Cancers · doi:10.3390/cancers14225681 · Cited by 18
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Rusu, M. C., Poalelungi, C. V., Vrapciu, A. D., Nicolescu, M. I., Hostiuc, S., Mogoantă, L., & Ţăranu, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0115853 · Cited by 18
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Pi, J., Cheng, Y., Sun, H., Chen, X., Zhuang, T., Liu, J., Li, Y., Chang, H. J., Zhang, L., Zhang, Y., et al. (2017) · BMC Ophthalmology · doi:10.1186/s12886-017-0556-6 · Cited by 18
Majid, Q. A., Ghimire, B. R., Merkely, B. P., RANDI, A. M., Harding, S. E., Talman, V., & Földes, G. (2024) · Angiogenesis · doi:10.1007/s10456-024-09929-5 · Cited by 17
Mercantepe, F., Şahin, S. B., Cüre, M. C., & Karadağ, Z. (2022) · Angiology · doi:10.1177/00033197221129358 · Cited by 17
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Bai, W., Ren, J.-S., Xia, M., Zhao, Y., Ding, J.-J., Chen, X., & Jiang, Q. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04225-0 · Cited by 17
Guo, Y., Zhang, S., Wang, D., Heng, B. C., & Deng, X. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01364-1 · Cited by 18
Oliveira, R. H. D. M., Annex, B. H., & Popel, A. S. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1351753 · Cited by 18
McAnally, D., Siddiquee, K., Gomaa, A. R., Szabo, A., Vasile, S., Maloney, P., Divlianska, D. B., Peddibhotla, S., Morfa, C. J., Hershberger, P., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202436 · Cited by 17
Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signaling Pathways
Gloger, M., Menzel, L., Grau, M., Vion, A.-C., Anagnostopoulos, I., Zapukhlyak, M., Gerlach, K., Kammertoens, T., Hehlgans, T., Zschummel, M., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-1493 · Cited by 19
Single-Cell Transcriptomic Analysis of Kaposi Sarcoma
Rauch, D. A., Ramos, P. V., Khanfar, M., Harding, J., Joseph, A., Fahad, A., Simonson, P. D., Risch, I., Griffith, O. L., Griffith, M., et al. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1012233 · Cited by 18
Lv, L.-L., Du, Y.-T., Chen, X., Yu, L., & Sun, F. (2022) · Brain Sciences · doi:10.3390/brainsci12111428 · Cited by 16
The mitochondrial protein TIMM44 is required for angiogenesis in vitro and in vivo
Ma, Z.-R., Li, H., Cai, S., Du, S.-Y., Chen, X., Yao, J., Cao, X., Zhen, Y.-F., & Wang, Q. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05826-9 · Cited by 16
Kelly, L., Sharp, M. M., Thomas, I., Brown, C., Schrag, M., Antunes, L. V., Solopova, E., Martínez‐González, J., Rodrı́guez, C., & Carare, R. O. (2023) · Cerebral Circulation - Cognition and Behavior · doi:10.1016/j.cccb.2023.100171 · Cited by 14
Epigenetic regulation of angiogenesis and its therapeutics
Choi, D. K. (2025) · Genomics & Informatics · doi:10.1186/s44342-025-00038-3 · Cited by 16
Silva, E. A., Eseonu, C. I., & Mooney, D. J. (2014) · Angiogenesis · doi:10.1007/s10456-014-9414-9 · Cited by 16
Buchberger, E., Payrhuber, D., Harchi, M. E., Zagrapan, B., Scheuba, K. M., Zommer, A., Bugyik, E., Döme, B., Kral-Pointner, J. B., Schrottmaier, W. C., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13477 · Cited by 16
Xu, H., & LaFlamme, S. E. (2022) · Cells · doi:10.3390/cells11050816 · Cited by 17
Neurovascular dynamics in the spinal cord from development to pathophysiology
de Almodóvar, C. R., Dupraz, S., & Bonanomi, D. (2025) · Neuron · doi:10.1016/j.neuron.2025.09.017 · Cited by 15
Parab, S., Setten, E., Astanina, E., Bussolino, F., & Doronzo, G. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108418 · Cited by 15
Chen, X., Yao, Y., Yuan, F., & Xie, B. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29733 · Cited by 15
Li, W., Liu, C., Burns, N. G., Hayashi, J., Yoshida, A., Sajja, A. P., González-Hernández, S., Gao, J., Murphy, P. M., Kubota, Y., et al. (2021) · Developmental Biology · doi:10.1016/j.ydbio.2021.05.008 · Cited by 15
APLN/APLNR Signaling Controls Key Pathological Parameters of Glioblastoma
Kälin, R., & Glass, R. (2021) · Cancers · doi:10.3390/cancers13153899 · Cited by 13
(2019) · Springer eBooks · doi:10.1007/978-3-319-33673-2 · Cited by 15
Metabolite-sensing GPCRs in rheumatoid arthritis
Yang, X., Zhang, W., Wang, L., Zhao, Y., & Wei, W. (2024) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.12.001 · Cited by 14
HtrA3‐Mediated Endothelial Cell–Extracellular Matrix Crosstalk Regulates Tip Cell Specification
Guo, Y., Ma, S., Xu, M., Wei, Y. Q., Zhang, X., Huang, Y., He, Y., Heng, B. C., Chen, L., & Deng, X. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202100633 · Cited by 14
Prognostic and Diagnostic Value of Endocan in Kidney Diseases
Samouilidou, E. C., Athanasiadou, V., & Grapsa, E. J. (2022) · International Journal of Nephrology · doi:10.1155/2022/3861092 · Cited by 14
New Insight on 2D In Vitro Angiogenesis Models: All That Stretches Is Not a Tube
Beloglazova, I. B., Zubkova, E., Дергилев, К. В., Goltseva, Y., & Parfyonova, Y. V. (2022) · Cells · doi:10.3390/cells11203278 · Cited by 14
Schilling, K. J., Zhai, Y., Zhou, Z., Zhou, B., Brown, E. B., & Zhang, X. (2022) · eLife · doi:10.7554/elife.83146 · Cited by 16
The non glycanated endocan polypeptide slows tumor growth by inducing stromal inflammatory reaction
Yassine, H., Caires, N. D. F., Depontieu, F., Scherpereel, A., Awad, A., Tsicopoulos, A., Lebœuf, C., Janin, A., Duez, C., Grigoriu, B. D., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2614 · Cited by 14
Growth factor signaling pathways in vascular development and disease
Grant, Z. L., & Coultas, L. (2019) · Growth Factors · doi:10.1080/08977194.2019.1635591 · Cited by 14
Metadata
- Authors
- del Toro, R., Prahst, C., Mathivet, T., Siegfried, G., Kaminker, J. S., Larrivee, B., Breant, C., Duarte, A., Takakura, N., Fukamizu, A., Penninger, J., & Eichmann, A.
- Affiliations
- Inserm U833, Paris, France;
- Inserm (FR)
- Inserm U770, Kremlin Bicetre Hospital, Paris, France;
- Genentech (US)
- Centro Interdisciplinar de Investigaçao em Sanidade Animal, Faculdade de Medicina Veterinaria, Technical University of Lisbon, Lisbon, Portugal;
- Research Institute for Microbial Diseases, The University of Osaka (JP)
- University of Tsukuba (JP)
- Institute of Molecular Biotechnology (AT)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2010-11-11
- Volume
- 116
- Issue
- 19
- Pages
- 4025-4033
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC4314527
- OpenAlex
- W2012483332
- Cited by
- 474
- References
- 48
- Citations by year
- 2026: 29 · 2025: 28 · 2024: 31 · 2023: 27 · 2022: 41 · 2021: 47 · 2020: 34 · 2019: 20 · 2018: 28 · 2017: 33 · 2016: 19 · 2015: 24 · 2014: 34 · 2013: 27 · 2012: 29
- FWCI
- 10.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Agence Nationale de la Recherche
- Fondation Leducq
- Institut National de la Santé et de la Recherche Médicale
- Institut National Du Cancer
- Japan Society for the Promotion of Science (22248040)
- National Heart, Lung, and Blood Institute (R01HL111504)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- endothelial tip cells, DLL4, Notch signaling, retinal endothelial cells, angiogenesis, stalk cells, extracellular matrix degradation, basement membrane, secreted molecules, apelin, angiopoietin-2, matrix remodeling, zebrafish morpholino knockdown, knockout mice
- MeSH terms
- Apelin, Apelin Receptors, Animals, Calcium-Binding Proteins, Capillaries, Carrier Proteins, Extracellular Matrix, Multigene Family, Membrane Proteins, Mice, Inbred C57BL, Retinal Vessels, Zebrafish, Signal Transduction, Mice, Knockout, Neovascularization, Physiologic, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Intercellular Signaling Peptides and Proteins, Vascular Endothelial Growth Factor A, Endothelial Cells, Receptors, G-Protein-Coupled, Intracellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing, Mice, Adipokines, Haploinsufficiency, TOR Serine-Threonine Kinases
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