The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Identification and functional analysis of endothelial tip cell–enriched genes
Open accessAbstract
Sprouting of developing blood vessels is mediated by specialized motile endothelial cells localized at the tips of growing capillaries. Following behind the tip cells, endothelial stalk cells form the capillary lumen and proliferate. Expression of the Notch ligand Delta-like-4 (Dll4) in tip cells suppresses tip cell fate in neighboring stalk cells via Notch signaling. In DLL4+/− mouse mutants, most retinal endothelial cells display morphologic features of tip cells. We hypothesized that these mouse mutants could be used to isolate tip cells and so to determine their genetic repertoire. Using transcriptome analysis of retinal endothelial cells isolated from DLL4+/− and wild-type mice, we identified 3 clusters of tip cell–enriched genes, encoding extracellular matrix degrading enzymes, basement membrane components, and secreted molecules. Secreted molecules endothelial-specific molecule 1, angiopoietin 2, and apelin bind to cognate receptors on endothelial stalk cells. Knockout mice and zebrafish morpholino knockdown of apelin showed delayed angiogenesis and reduced proliferation of stalk cells expressing the apelin receptor APJ. Thus, tip cells may regulate angiogenesis via matrix remodeling, production of basement membrane, and release of secreted molecules, some of which regulate stalk cell behavior.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Integrins, which regulate endothelial cell–cell and cell–matrix interactions, have been identified as alternative receptors for the angiopoietins in certain Tie2-negative non-endothelial cells22232425, and in the endothelial tip cells of angiogenic vessel sprouts, which express low levels of Tie2 (refs 26, 27).”
From Endothelial destabilization by angiopoietin-2 via integrin β1 activation (2015) · cites this paper as [26]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) · Science · doi:10.1126/science.277.5322.55 · Cited by 3,570
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302047 · Cited by 2,894
Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor
Tatemoto, K., Hosoya, M., Habata, Y., Fujii, R., Kakegawa, T., Zou, M.-X., Kawamata, Y., Fukusumi, S., Hinuma, S., Kitada, C., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9489 · Cited by 1,684
Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system
Augustin, H. G., Koh, G. Y., Thurston, G., & Alitalo, K. K. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2639 · Cited by 1,512
multifunctional enzymes in cancer
Mohamed, M. M., & Sloane, B. F. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1949 · Cited by 1,303
uPAR: a versatile signalling orchestrator
Blasi, F., & Carmeliet, P. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm977 · Cited by 1,224
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
Noguera‐Troise, I., Daly, C., Papadopoulos, N. J., Coetzee, S., Boland, P., Gale, N. W., Lin, H. C., Yancopoulos, G. D., & Thurston, G. (2006) · Nature · doi:10.1038/nature05355 · Cited by 1,032
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
Ridgway, J., Zhang, G., Wu, Y., Stawicki, S., Liang, W.-C., Chanthery, Y., Kowalski, J., Watts, R. J., Callahan, C., Kasman, I., et al. (2006) · Nature · doi:10.1038/nature05313 · Cited by 986
Suchting, S., Freitas, C., le Noble, F. A. C., Benedito, R., Bréant, C., Duarte, A., & Eichmann, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611177104 · Cited by 846
Self-citationBlocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
Tammela, T., Zarkada, G., Wallgard, E., Murtomäki, A., Suchting, S., Wirzenius, M., Waltari, M., Hellström, M., Schomber, T., Peltonen, R., et al. (2008) · Nature · doi:10.1038/nature07083 · Cited by 834
Self-citation
Cited by
Sorted by citations
Items 301–400 of 473
Li, K., Huang, Z., Tian, S., Chen, Y., Yuan, Y., Yuan, J., Zou, X., & Zhou, F. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107530 · Cited by 14
Robillard, S., Trân, K., Lachance, M.-S., Brazeau, T., Boisvert, E., Lizotte, F., Auger‐Messier, M., Boudreault, P., Marsault, É., & Geraldes, P. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1191891 · Cited by 13
Angiogenesis of Avascular Necrosis of the Femoral Head: A Classic Treatment Strategy
Wang, P., Shao, W., Wang, Y., Wang, B., Lv, X., & Feng, Y. (2024) · Biomedicines · doi:10.3390/biomedicines12112577 · Cited by 13
Brain injury triggers cell‐type‐specific and time‐dependent endoplasmic reticulum stress responses
Fan, Q., Takarada‐Iemata, M., Okitani, N., Tamatani, T., Ishii, H., Hattori, T., Kiryu‐Seo, S., Kiyama, H., & Hori, O. (2022) · Glia · doi:10.1002/glia.24303 · Cited by 13
Establishment of an abnormal vascular patterning model in the mouse retina
Morita, A., Sawada, S., Mori, A., Arima, S., Sakamoto, K., Nagamitsu, T., & Nakahara, T. (2018) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2018.03.002 · Cited by 13
Park, J. A., Kim, D. Y., Kim, Y., Lee, I., & Kwon, Y. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005324 · Cited by 14
Vascular development, remodeling and maturation
Furtado, J., & Eichmann, A. (2024) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2024.02.001 · Cited by 13
Self-citationIntramyocardial Sprouting Tip Cells Specify Coronary Arterialization
Cano, E., Schwarzkopf, J. B., Kanda, M., Lindberg, E. L., Hollfinger, I., Pogontke, C., Braeuning, C., Fischer, C., Hübner, N., & Gerhardt, H. (2024) · Circulation Research · doi:10.1161/circresaha.124.324868 · Cited by 12
Oral, E., Halıcı, Z., Çınar, İ., Ozcan, E., & Kutlu, Z. (2019) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2019.17.2.211 · Cited by 12
Nikmaneshi, M. R., Firoozabadi, B., & Mozafari, A. (2021) · Biotechnology and Bioengineering · doi:10.1002/bit.27863 · Cited by 12
Mechanosensitive PIEZO2 channels shape coronary artery development
Pampols-Perez, M., Fürst, C., Sánchez-Carranza, O., Cano, E., García-Contreras, J. A., Mais, L., Luo, W., Raimundo, S., Lindberg, E. L., Taube, M., et al. (2025) · Nature Cardiovascular Research · doi:10.1038/s44161-025-00677-3 · Cited by 14
Serum endocan levels in patients with cardiac syndrome X
Efe, S. Ç., Demirci, K., Öztürk, S., Gürbüz, A. S., Poçi, N., Kılıçgedik, A., Güler, A., Yılmaz, M. F., İzgi, İ. A., & Kırma, C. (2017) · Herz · doi:10.1007/s00059-017-4580-3 · Cited by 11
Sprouting Angiogenesis in Human Pituitary Adenomas
Zhou, J., Hu, Y., Zhu, W., Nie, C., Zhao, W., Faje, A. T., Labelle, K. E., Swearingen, B., Lee, H., Hedley‐Whyte, E. T., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.875219 · Cited by 12
The H2.0-Like Homeobox Transcription Factor Modulates Yolk Sac Vascular Remodeling in Mouse Embryos
Prahst, C., Kasaai, B., Moraes, F., Jahnsen, E. D., Larrivée, B., Villegas, D., Pardanaud, L., Pibouin-Fragner, L., Zhang, F., Zaun, H. C., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303626 · Cited by 11
Self-citationTsuji, M., Kondo, M., Sato, Y., Miyoshi, A., Kobayashi, F., Arimura, K., Yamashita, K., Morimoto, S., Yanagisawa, N., Ichihara, A., et al. (2024) · Cytokine · doi:10.1016/j.cyto.2024.156583 · Cited by 11
Endocan immunoreactivity in the mouse brain: Method for identifying nonfunctional blood vessels
Frahm, K., Nash, C. P., & Tobet, S. A. (2013) · Journal of Immunological Methods · doi:10.1016/j.jim.2013.09.005 · Cited by 10
Halici, I., Palabıyık, Ş. S., Guducu‐Tufekci, F., Bilgin, A. Ö., & Çayır, A. (2016) · Pediatrics International · doi:10.1111/ped.12989 · Cited by 10
Guo, Z., & Mo, Z. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119406 · Cited by 10
The blood vasculature instructs lymphatic patterning in a SOX7‐dependent manner
Chiang, I. K., Graus, M. S., Kirschnick, N., Davidson, T., Luu, W., Harwood, R., Jiang, K., Li, B., Wong, Y. Y., Moustaqil, M. D., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2021109032 · Cited by 10
Wnt inhibition promotes vascular specification of embryonic cardiac progenitors
Reichman, D. E., Park, L., Man, L., Redmond, D., Chao, K., Harvey, R. P., Taketo, M. M., Rosenwaks, Z., & James, D. (2018) · Development · doi:10.1242/dev.159905 · Cited by 10
Sheldon, H., Zhang, W., Bridges, E., Ang, K. H., Lin, S., Masiero, M., Li, D., Handford, P. A., Whiteman, P., Fischer, R., et al. (2022) · Journal of Extracellular Biology · doi:10.1002/jex2.52 · Cited by 9
Revealing the pathogenesis of keloids based on the status: Active vs inactive
Oh, S., Yeo, E., Shim, J., Noh, H., Park, J., Lee, K., Kim, S., Lee, D., & Lee, J. H. (2024) · Experimental Dermatology · doi:10.1111/exd.15088 · Cited by 12
RNF20-mediated transcriptional pausing and VEGFA splicing orchestrate vessel growth
Tetik-Elsherbiny, N., Elsherbiny, A., Setya, A., Gahn, J., Tang, Y., Gupta, P., Dou, Y., Serke, H., Wieland, T., Dubrac, A., et al. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00546-5 · Cited by 11
Endocan, a Potential Biomarker of Endothelial Dysfunction: A Brief Overview
Bidlan, M., Kumar, M., Bhargava, A., Goel, V., & Kumar, V. (2025) · Angiology · doi:10.1177/00033197251356576 · Cited by 10
Lam, J., Yu, J., Lee, B., Campagna, C., Yoo, S., Baek, K., Jeon, N. L., & Sung, K. E. (2023) · Advanced Biology · doi:10.1002/adbi.202300094 · Cited by 9
Long Non-Coding RNA LINC02802 Regulates In Vitro Sprouting Angiogenesis by Sponging microRNA-486-5p
Rosano, S., Parab, S., Noghero, A., Corà, D., & Bussolino, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031653 · Cited by 10
Ito, H., Nashimoto, Y., Zhou, Y., Takahashi, Y., Ino, K., Shiku, H., & Matsue, T. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b04338 · Cited by 9
Arteriogenesis versus angiogenesis
Carmeliet, P., Eelen, G., & Kalucka, J. M. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780198755777.003.0008 · Cited by 8
A human developing heart atlas reveals cardiovascular cell diversity for in vitro model benchmarkingPreprint
Knight-Schrijver, V. R., Bayraktar, S., Cranley, J. J., Kanemaru, K., Waller, B., Colzani, M., Wong, C., Davaapil, H., Lee, J. C. M., D'Souza, M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.27.591127 · Cited by 9
Repression of apelin Furin cleavage sites provides antimetastatic strategy in colorectal cancer
Demoures, B., Soulet, F., Descarpentrie, J., Galeano-Otero, I., Collado, J. S., Casado, M., Smani, T., Gonzalez, A. F., Alves, I. D., Lalloué, F., et al. (2025) · EMBO Molecular Medicine · doi:10.1038/s44321-025-00196-5 · Cited by 8
Self-citationThe histone acetyltransferase HBO1 promotes efficient tip cell sprouting during angiogenesis
Grant, Z. L., Hickey, P. F., Abeysekera, W., Whitehead, L. W., Lewis, S. M., Symons, R. C. A., Baldwin, T. M., Amann‐Zalcenstein, D., Garnham, A. L., Naik, S. H., et al. (2021) · Development · doi:10.1242/dev.199581 · Cited by 8
Ludewig, P., Flachsbarth, K., Wegscheid, C., Tiegs, G., Richard, G., Wagener, C., Bartsch, U., & Horst, A. K. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-13403 · Cited by 8
Khatib, A., Lahlil, R., Hagedorn, M., Deloménie, C., Christophe, O. D., Denis, C. V., & Siegfried, G. (2016) · Oncotarget · doi:10.18632/oncotarget.7728 · Cited by 8
Self-citationCaires, N. D. F., & Lassalle, P. (2015) · Circulation Research · doi:10.1161/circresaha.115.306353 · Cited by 8
Novel Populations of Lung Capillary Endothelial Cells and Their Functional SignificancePreprint
James, J., Dekan, A., Niihori, M., McClain, N., Varghese, M. V., Bharti, D., Lawal, O., Padilla‐Rodriguez, M., Yi, D., Dai, Z., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2887159/v1 · Cited by 8
The role of RNA interference in the developmental separation of blood and lymphatic vasculature
Gauvrit, S., Philippe, J., Lesage, M., Tjwa, M., Godin, I., & Germain, S. (2014) · Vascular Cell · doi:10.1186/2045-824x-6-9 · Cited by 7
miRNA Levels as a Biomarker for Anti-VEGF Response in Patients with Diabetic Macular Edema
Vader, M. J. C., Habani, Y. I., Schlingemann, R. O., & Klaassen, I. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11121297 · Cited by 7
Identification of New Markers of Angiogenic Sprouting Using Transcriptomics: New Role for RND3
Abbey, C. A., Duran, C. L., Chen, Z., Chen, Y., Roy, S., Coffell, A., Sveeggen, T. M., Chakraborty, S., Wells, G. B., Chang, J., et al. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.320599 · Cited by 7
Loss of apelin blocks the emergence of sprouting angiogenesis in experimental tumors
Azad, A. K., Campbell, K. R., Zhabyeyev, P., Oudit, G. Y., Moore, R. B., & Murray, A. G. (2022) · The FASEB Journal · doi:10.1096/fj.202200616rr · Cited by 7
The Relationship between Serum Endocan Levels and Depression in Alzheimer’s Disease
Yoon, K. H., Kim, S. Y., Moon, Y. S., Roh, D. D., Lee, S., & Kim, D. H. (2016) · Disease Markers · doi:10.1155/2016/8254675 · Cited by 7
Lin, P. K., Salvador, J., Xie, J., Aguera, K. N., Koller, G. M., Kemp, S. S., Griffin, C. T., & Davis, G. E. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.08.017 · Cited by 7
Molecular Regulation of Vasculogenesis and Angiogenesis: Recent Advances and Future Directions
Davis, G. E. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-906-8_6 · Cited by 7
Shirazi, S. P., Negretti, N. M., Jetter, C. S., Sharkey, A. L., Garg, S., Kapp, M., Wilkins, D. J., Fortier, G., Mallapragada, S., Banovich, N. E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.27.609955 · Cited by 7
Advanced biomaterial-based strategies for craniofacial bone regeneration
Du, J., Huang, Y., Liu, Y., Wu, Y., Zhou, M., & Jiang, X. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123736 · Cited by 6
Distinct populations of lung capillary endothelial cells and their functional significance
James, J., Dekan, A., Kaçar, S., Niihori, M., Sano, T., McClain, N., Varghese, M. V., Bharti, D., Lawal, O., Padilla‐Rodriguez, M., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-09420-x · Cited by 15
The spatiotemporal dynamics of postnatal vascularization in the mouse brain
de Launoit, E., Skriabine, S., Doumazane, E., Bizou, M., Pommé, R., Lienhard, G., Rajot, D., Mikhailenko, A., Prado, A. V., Lannes, M., et al. (2026) · Cell · doi:10.1016/j.cell.2026.03.013 · Cited by 7
Liu, Z., Tanke, N. T., Neal, A. E., Yu, T., Branch, T., Sharma, A., Cook, J. G., & Bautch, V. L. (2024) · Angiogenesis · doi:10.1007/s10456-024-09920-0 · Cited by 6
Network-Based Analysis Reveals Gene Signature in Tip Cells and Stalk Cells
Li, C., & Xu, L. (2021) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520621666210720120218 · Cited by 6
CCRL2 Modulates Physiological and Pathological Angiogenesis During Retinal Development
Dhaou, C. B., Prete, A. D., Sozzani, S., & Parmentier, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.808455 · Cited by 6
The effect of fibroblast growth factor 2 on neovascular vessels depends on the stage of angiogenesis
Hattori, Y., Yamada, H., Mori, H., Oba, S., Yokota, K., Omi, M., Yamamoto, Y., Toyama, K., Ohnaka, M., Takahashi, K. A., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e39843 · Cited by 5
Apelin as a CNS-specific pathway for fenestrated capillary formation in the choroid plexus
Herdt, L., Baumeister, S., Ravindra, J., Eberlein, J., & Helker, C. S. (2025) · Nature Communications · doi:10.1038/s41467-025-63003-2 · Cited by 5
Xie, B., Zhou, X., & Qiu, J. (2022) · BMC Pediatrics · doi:10.1186/s12887-022-03306-1 · Cited by 6
Automated tracking and quantification of angiogenic vessel formation in 3D microfluidic devices
Wang, M., Ong, L. S., Dauwels, J., & Asada, H. H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186465 · Cited by 5
Epigenetic Regulation of the Vascular Endothelium by Angiogenic LncRNAs
Subramaniam, N., Nair, R., & Marsden, P. A. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.668313 · Cited by 5
Yamamoto, T., Takahashi, S., Hasegawa, T., Hongo, H., & Amizuka, N. (2022) · Journal of Oral Biosciences · doi:10.1016/j.job.2022.04.006 · Cited by 5
Anti-angiogenic Targets: Angiopoietin and Angiopoietin-Receptors
Kiss, E. A., & Saharinen, P. (2017) · Springer eBooks · doi:10.1007/978-3-319-31215-6_4-1 · Cited by 5
Quantitative mass spectrometry‐based proteomics in angiogenesis
Hernandez-Fernaud, J. R., Reid, S. E., Neilson, L. J., & Zanivan, S. R. (2012) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201200055 · Cited by 5
mTOR as a Modulator of Metabolite Sensing Relevant to Angiogenesis
Soumya, S. J., Athira, A. P., Binu, S., & Sudhakaran, P. R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802733-2.00014-1 · Cited by 5
Zonal endothelial cell heterogeneity underlies murine renal vascular development
Luo, P. M., Ahuja, N. H., Chaney, C. P., Pi, D., Cwiek, A., Markowska, Z., Hiremath, C., Marciano, D. K., Hirschi, K. K., Iruela‐Arispe, M. L., et al. (2025) · Angiogenesis · doi:10.1007/s10456-025-10000-0 · Cited by 4
Parsons, A. M., Ahsan, N., & Darling, E. M. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10889-6 · Cited by 4
Expression and function of Delta-like ligand 4 in a rat model of retinopathy of prematurity.
ShaoyangShi, Li, X., YouLi, CunwenPei, HongweiYang, & XiaolongChen (2013) · PubMed · doi:10.3969/j.issn.1673-5374.2013.08.007 · Cited by 4
Human and equine endothelial cells in a live cell imaging scratch assay in vitro
Rieger, J., Hopperdietzel, C., Kaessmeyer, S., Slosarek, I., Diecke, S., Richardson, K., & Plendl, J. (2018) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-189316 · Cited by 4
Kang, N., Liang, X. Y., Fan, B., Zhao, C., Shen, B., Ji, X., & Liu, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-1997200/v1 · Cited by 4
Dobner, S., Kleißl, L., Tóth, F., Paxton, R. L., Yordanova, I., Brazdilova, K., Vanluyten, C., Aizenshtadt, A., Toth, H., Burton, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.18.669055 · Cited by 4
Xia, J., Wang, W. Y., Jacobs, K. A., Maniar, K., Lin, D., Jarman, E. H., Matera, D. L., Loesel, K., Davidson, C. D., Hiraki, H. L., et al. (2026) · Advanced Science · doi:10.1002/advs.202510448 · Cited by 3
Endothelial Zmiz1 modulates developmental angiogenesis in the retina
Patel, N. R., Bavishi, S., Guidroz, A. P., Rajan, K. C., Blanks, A., Carter, K., Chiang, M. Y., & Meadows, S. M. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1570587 · Cited by 3
Decoding the spatiotemporal development of human meninges
Li, Y., Li, Z., She, Y., He, Z., Wang, C., Zhang, Y., Li, R., Jin, L., Ji, F., Du, P., et al. (2026) · Cell · doi:10.1016/j.cell.2026.04.040 · Cited by 3
Park, H., Adams, R. H., & Kim, K.-P. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01760-w · Cited by 3
Esm-1 mediates transcriptional polarization associated with diabetic kidney disease
Gaudet, A., Zheng, X., Kambham, N., & Bhalla, V. (2024) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00419.2023 · Cited by 3
Genetic and Molecular Basis for Hereditary Hemorrhagic Telangiectasia
Roman, B. L., & Finegold, D. N. (2014) · Current Genetic Medicine Reports · doi:10.1007/s40142-014-0061-7 · Cited by 3
Ellis, L. V., Kong, C. S. L., & Chen, J. (2021) · European Respiratory Society eBooks · doi:10.1183/2312508x.10009820 · Cited by 3
Sun, S., Cao, C., Guo, Y., Hou, Y., Meng, Y., Li, Y., Feng, M., Hu, Z., Li, Y., Niu, Y., et al. (2022) · Advanced Materials Interfaces · doi:10.1002/admi.202201719 · Cited by 3
Fang, C., Avis, I. M., Bianco, C., Held, N., Morris, J. F., Ylaya, K., Hewitt, S. M., Aplin, A. C., Nicosia, R. F., Fung, L. A., et al. (2013) · Open Journal of Clinical Diagnostics · doi:10.4236/ojcd.2013.32009 · Cited by 3
General Concepts of Blood Vessel Formation and Remodeling
Tomanek, R. J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4887-7_1 · Cited by 3
Kälin, S., & Kälin, R. E. (2016) · Energy balance and cancer · doi:10.1007/978-3-319-41677-9_7 · Cited by 3
Cammeraat, M., Popovic, M. A., Stam, W., & Margadant, C. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-2887-4_21 · Cited by 3
Jian, T., Sivitilli, A., Guo, Y. E., Stirton, C., Gosio, J., Tsukahara, Y., Tkach, J. M., Lu, S., Yarmand, A., Mangos, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.21.713033 · Cited by 3
Endothelial-specific Enhancer as a Cis Element of PLAUR Regulation by TNF-alpha, IL-1beta, and VEGF
Penkov, D., Beloglazova, I. B., & Parfyonova, Y. V. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128296376240424072322 · Cited by 2
Ueda, C., Sakimoto, S., Yoshihara, M., Takigawa, T., Shiraki, A., Yamaguchi, K., Shiki, K., Shiraki, N., Kitajima, S., Kubota, Y., et al. (2024) · iScience · doi:10.1016/j.isci.2024.111516 · Cited by 2
Apelin signaling acts as a molecular switch between endothelial and hematopoietic stem cell fates
Eberlein, J., Groos, N., Duwal, N. S., Sugden, W. W., North, T. E., & Helker, C. S. (2025) · EMBO Reports · doi:10.1038/s44319-025-00656-6 · Cited by 2
Shan, J., Shi, R., Jiang, L., Dufort, C., Miao, W., Mai, T.-W., Lyu, J., Barreiro, J., Chen, K., Leak, R. K., et al. (2026) · iScience · doi:10.1016/j.isci.2026.115331 · Cited by 2
Decoding the spatiotemporal development of the blood-brain barrier in human cortex
Li, Z., Li, W., He, Z., Wang, C., Zhang, Y., Li, R., Jin, L., Jiao, J., Ji, F., Zhu, B., et al. (2026) · Cell stem cell · doi:10.1016/j.stem.2026.02.010 · Cited by 2
In vivo measurement of an Apelin gradient with a genetically encoded APLNR conformation biosensor
Herdt, L., Schihada, H., Kurz, M., Ernst, S., Eberlein, J., Kolb, P., Krasel, C., Buenemann, M., & Helker, C. S. (2025) · Nature Communications · doi:10.1038/s41467-025-61781-3 · Cited by 2
Vascularization of neonatal liver lobules presages adult liver size
Azizoglu, D. B., Perez, K., Zheng, S. L., Rahman, S., Rim, E. Y., Anbarchian, T., Fish, M., Loh, K. M., Red‐Horse, K., & Nusse, R. (2025) · Nature Communications · doi:10.1038/s41467-025-64930-w · Cited by 2
Brizzi, M. F., & Defilippi, P. (2013) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2218-6751.2013.10.18 · Cited by 2
Kumar, A., Desai, S., & Pandey, B. N. (2013) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2218-6751.2013.09.01 · Cited by 2
Palm, M. M., Dallinga, M. G., vanDijk, E., Klaassen, I., Schlingemann, R. O., & Merks, R. M. H. (2014) · Centrum Wiskunde & Informatica (CWI), the national research institute for mathematics and computer science in the Netherlands · Cited by 2
Notch controls arterialization by regulating the cell cycle and not differentiationPreprint
Luo, W., García-Gónzalez, I., Fernández-Chacón, M., Casquero-García, V., & Benedito, R. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.07.192344 · Cited by 2
Winters, N. I., Taylor, C. J., Jetter, C. S., Camarata, J. E., Gutierrez, A. J., Bui, L. T., Gokey, J. J., Bacchetta, M. D., Banovich, N. E., Sucre, J. M. S., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.19.457016 · Cited by 2
Androgen Receptor Governs Tip Cell Formation in Cerebrovascular Malformations
Li, R., Yu, L., Xu, M., Xiao, X., Tang, Y., Lv, C., Zhang, Y., Hong, T., & Wang, Y. (2025) · Circulation Research · doi:10.1161/circresaha.125.326471 · Cited by 1
Anisimov, A., Lackman, M. H., Augustin, H. G., Mervaala, E. M. A., Alitalo, K. K., & Karaman, S. (2026) · Angiogenesis · doi:10.1007/s10456-025-10028-2 · Cited by 1
Singh, A., Mehani, B., Gopalan, V., Puri, S., Aldape, K., & Hannenhalli, S. S. (2026) · Molecular Systems Biology · doi:10.1038/s44320-026-00201-0 · Cited by 1
Orai1 Facilitates Angiogenesis After Myocardial Infarction Through Notch1 Signaling Pathway
Galeano-Otero, I., Dominguez-Liste, B., Aspron, C., Fernández-Chacón, M., Escacena-Izquierdo, L., Toro, R. D., Rojas-Torres, M., Durán-Ruiz, M. C., Siegfried, G., Ordóñez, A., et al. (2026) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.324231 · Cited by 1
Self-citationHypoxia differentially affects coronary vessel formation during heart development
Payne, S., Bruche, S., Szumska, D., Fleisinger, L., Neal, A., Preston, M. D., & Val, S. D. (2026) · Cardiovascular Research · doi:10.1093/cvr/cvag124 · Cited by 1
Apelin Signaling in Retinal Angiogenesis
Audigier, Y., Berghe, L. V. D., & Masri, B. (2014) · Springer eBooks · doi:10.1007/978-2-8178-0466-8_6 · Cited by 1
More than a Scaffold: Extracellular Matrix in Vascular Signaling
Nikolić, I. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2907-8_7 · Cited by 1
The process of endothelial cell migration during tumor angiogenesis
YuLin, L. I., Li, L., Xiao, S. O. N. G., Man, L. U., & MeiYu, S. U. N. (2013) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/972012-1859 · Cited by 1
Angiodiversity—A tale retold by comparative transcriptomics
Gu, X., & Cleaver, O. B. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822546-2.00029-0 · Cited by 1
Laloğlu, F., Laloğlu, E., Cevi̇z, N., & Güler, M. A. (2022) · Cardiology in the Young · doi:10.1017/s1047951122002530 · Cited by 1
The Role of Paladin in Endothelial Cell Signaling and Angiogenesis
Nitzsche, A. (2016) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 1
Metadata
- Authors
- del Toro, R., Prahst, C., Mathivet, T., Siegfried, G., Kaminker, J. S., Larrivee, B., Breant, C., Duarte, A., Takakura, N., Fukamizu, A., Penninger, J., & Eichmann, A.
- Affiliations
- Inserm U833, Paris, France;
- Inserm (FR)
- Inserm U770, Kremlin Bicetre Hospital, Paris, France;
- Genentech (US)
- Centro Interdisciplinar de Investigaçao em Sanidade Animal, Faculdade de Medicina Veterinaria, Technical University of Lisbon, Lisbon, Portugal;
- Research Institute for Microbial Diseases, The University of Osaka (JP)
- University of Tsukuba (JP)
- Institute of Molecular Biotechnology (AT)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2010-11-11
- Volume
- 116
- Issue
- 19
- Pages
- 4025-4033
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC4314527
- OpenAlex
- W2012483332
- Cited by
- 474
- References
- 48
- Citations by year
- 2026: 29 · 2025: 28 · 2024: 31 · 2023: 27 · 2022: 41 · 2021: 47 · 2020: 34 · 2019: 20 · 2018: 28 · 2017: 33 · 2016: 19 · 2015: 24 · 2014: 34 · 2013: 27 · 2012: 29
- FWCI
- 10.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Agence Nationale de la Recherche
- Fondation Leducq
- Institut National de la Santé et de la Recherche Médicale
- Institut National Du Cancer
- Japan Society for the Promotion of Science (22248040)
- National Heart, Lung, and Blood Institute (R01HL111504)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- endothelial tip cells, DLL4, Notch signaling, retinal endothelial cells, angiogenesis, stalk cells, extracellular matrix degradation, basement membrane, secreted molecules, apelin, angiopoietin-2, matrix remodeling, zebrafish morpholino knockdown, knockout mice
- MeSH terms
- Apelin, Apelin Receptors, Animals, Calcium-Binding Proteins, Capillaries, Carrier Proteins, Extracellular Matrix, Multigene Family, Membrane Proteins, Mice, Inbred C57BL, Retinal Vessels, Zebrafish, Signal Transduction, Mice, Knockout, Neovascularization, Physiologic, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Intercellular Signaling Peptides and Proteins, Vascular Endothelial Growth Factor A, Endothelial Cells, Receptors, G-Protein-Coupled, Intracellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing, Mice, Adipokines, Haploinsufficiency, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
