The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
NFIL3/E4BP4 is a key transcription factor for CD8α+ dendritic cell development
Open accessAbstract
Antigen presentation by mature dendritic cells (DCs) is the first step for initiating adaptive immune responses. DCs are composed of heterogeneous functional subsets; however, the molecular mechanisms that regulate differentiation of specific DC subsets are not understood. Here, we report that the basic leucine zipper transcription factor NFIL3/E4BP4 is essential for the development of CD8α+ conventional DCs (cDCs). Nfil3−/− mice specifically lack CD8α+ cDCs but not CD8α− cDCs or plasmacytoid DCs in lymphoid tissues. Flt3 ligand–dependent generation of CD8α+ cDCs in lymphoid tissues and CD8α+-equivalent cDCs from Nfil3−/− bone marrow cells was also impaired. NFIL3 regulates CD8α+ cDC development in part through Batf3 expression. Importantly, Nfil3−/− mice exhibited impaired cross-priming of CD8+ T cells against cell-associated antigen, a process normally performed by CD8α+ cDCs, and failed to produce IL-12 after TLR3 stimulation. Thus, NFIL3 plays an essential role in the development of CD8α+ cDCs.
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Cites
Batf3 Deficiency Reveals a Critical Role for CD8α + Dendritic Cells in Cytotoxic T Cell Immunity
Hildner, K., Edelson, B. T., Purtha, W. E., Diamond, M., Matsushita, H., Kohyama, M., Calderon, B., Schraml, B. U., Unanue, E. R., Diamond, M. S., et al. (2008) · Science · doi:10.1126/science.1164206 · Cited by 2,081
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Cabeza-Cabrerizo, M., Cardoso, A., Minutti, C. M., Pereira da Costa, M., & Reis e Sousa, C. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-061020-053707 · Cited by 757
Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity
Brown, C. C., Gudjonson, H., Pritykin, Y., Deep, D., Lavallée, V.-P., Mendoza, A., Fromme, R., Mazutis, L., Ariyan, C., Leslie, C., et al. (2019) · Cell · doi:10.1016/j.cell.2019.09.035 · Cited by 601
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Satpathy, A. T., Wu, X., Albring, J. C., & Murphy, K. M. (2012) · Nature Immunology · doi:10.1038/ni.2467 · Cited by 441
Chopin, M., Lun, A. T., Zhan, Y., Schreuder, J., Coughlan, H., D’Amico, A., Mielke, L. A., Almeida, F. F., Kueh, A. J., Dickins, R. A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.11.010 · Cited by 104
Metadata
- Authors
- Kashiwada, M., Pham, N.-L. L., Pewe, L. L., Harty, J. T., & Rothman, P. B.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2011-06-09
- Volume
- 117
- Issue
- 23
- Pages
- 6193-6197
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1965218665
- Cited by
- 182
- References
- 1
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Kashiwada, M., Pham, N.-L. L., Pewe, L. L., Harty, J. T., & Rothman, P. B. (2011). NFIL3/E4BP4 is a key transcription factor for CD8α+ dendritic cell development. Blood. https://doi.org/10.1182/blood-2010-07-295873
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