Complement halts angiogenesis gone wild
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In this issue of Blood, Langer and colleagues demonstrate the inhibitory role of the complement system during neovascularization, which is mediated by complement-stimulated macrophages in both a mouse model of retinopathy of prematurity and in a Matrigel culture model.1
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The anaphylatoxins C3a and C5a have been found to enhance laser-induced CNV in some cases, but may have anti-angiogenic properties in mouse models of retinal hypoxia through the stimulation of mononuclear phagocytes to secrete soluble VEGF receptor 1 that inhibits VEGF.
“For instance, the anaphylatoxins C3a and C5a have been found to enhance laser-induced CNV in some cases, but may have anti-angiogenic properties in mouse models of retinal hypoxia through the stimulation of mononuclear phagocytes to secrete soluble VEGF receptor 1 that inhibits VEGF [169,170].”
From Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration (2023) · cites this paper as [169]
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Hammadi, S., Tzoumas, N., Ferrara, M., Meschede, I. P., Lo, K., Harris, C., Lako, M., & Steel, D. H. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082870 · Cited by 44 · see citing works
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Tzoumas, N., Hallam, D., Harris, C. L., Lako, M., Kavanagh, D., & Steel, D. H. W. (2021) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2020.10.008 · Cited by 33 · see citing works
- Authors
- Kahr, W. H. A.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Kahr, Walter H. A.
- ORCID
- Kahr, Walter H. A.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2010-11-25
- Volume
- 116
- Issue
- 22
- Pages
- 4393-4394
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1970196001
- Cited by
- 11
- References
- 11
- Citations by year
- 2023: 2 · 2022: 2 · 2020: 1 · 2019: 1 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- complement system, angiogenesis, neovascularization, retinopathy of prematurity
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