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How I treat hemophagocytic lymphohistiocytosis
Open accessAbstract
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation, occurring as either a familial disorder or a sporadic condition, in association with a variety of triggers. This immune dysregulatory disorder is prominently associated with cytopenias and a unique combination of clinical signs and symptoms of extreme inflammation. Prompt initiation of immunochemotherapy is essential for survival, but timely diagnosis may be challenging because of the rarity of HLH, its variable presentation, and the time required to perform diagnostic testing. Therapy is complicated by dynamic clinical course, high risk of treatment-related morbidity, and disease recurrence. Here, we review the clinical manifestations and patterns of HLH and describe our approach to the diagnosis and therapy for this elusive and potentially lethal condition.
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Bleesing, J., Prada, A., Siegel, D. M., Villanueva, J., Olson, J., Ilowite, N. T., Brunner, H. I., Griffin, T., Graham, T. B., Sherry, D. D., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22416 · Cited by 321
Self-citationFall, N., Barnes, M., Thornton, S., Luyrink, L., Olson, J., Ilowite, N. T., Gottlieb, B. S., Griffin, T., Sherry, D. D., Thompson, S., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22981 · Cited by 245
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Locatelli, F., Jordan, M. B., Allen, C., Cesaro, S., Rizzari, C., Rao, A., Degar, B., Garrington, T. P., Sevilla, J., Putti, M.-C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1911326 · Cited by 534
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A consensus review on malignancy‐associated hemophagocytic lymphohistiocytosis in adults
Daver, N., McClain, K., Allen, C. E., Parikh, S. A., Otrock, Z., Rojas‐Hernandez, C., Blechacz, B., Wang, S., Minkov, M., Jordan, M. B., et al. (2017) · Cancer · doi:10.1002/cncr.30826 · Cited by 258
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Metadata
- Authors
- Jordan, M. B., Allen, C. E., Weitzman, S., Filipovich, A. H., & McClain, K. L.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2011-10-13
- Volume
- 118
- Issue
- 15
- Pages
- 4041-4052
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2155477306
- Cited by
- 1,148
- References
- 2
- FWCI
- 28.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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