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Cited by 222Multiple Myeloma Research and TreatmentsProtein Degradation and InhibitorsBone health and treatments

Pomalidomide plus low-dose dexamethasone in myeloma refractory to both bortezomib and lenalidomide: comparison of 2 dosing strategies in dual-refractory disease

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Lacy, Martha Q., Allred, Jacob B., Gertz, Morie A., Hayman, Suzanne R., Short, Kristen Detweiler, Buadi, Francis, Dispenzieri, Angela, Kumar, Shaji +14 more·2011·Blood
DOI 10.1182/blood-2011-04-348896PMC PMC3291492
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Abstract

Pomalidomide at doses of 2 or 4 mg/d has demonstrated excellent activity in patients with multiple myeloma (MM). We opened 2 sequential phase 2 trials using the pomalidomide with weekly dexamethasone (Pom/dex) regimen at differing doses to study the efficacy of this regimen in patients who have failed both lenalidomide and bortezomib. Pomalidomide was given orally 2 or 4 mg daily with dexamethasone 40 mg weekly. Thirty-five patients were enrolled in each cohort. Confirmed responses in the 2-mg cohort consisted of very good partial response (VGPR) in 5 (14%), partial response (PR) in 4 (11%), minor response (MR) in 8 (23%) for an overall response rate of 49%. In the 4-mg cohort, confirmed responses consisted of complete response (CR) in 1 (3%), VGPR in 3 (9%), PR in 6 (17%), MR in 5 (14%) for an overall response rate of 43%. Overall survival at 6 months is 78% and 67% in the 2- and 4-mg cohort, respectively. Myelosuppression was the most common toxicity. This nonrandomized data suggests no advantage for 4 mg over the 2 mg daily. Pomalidomide overcomes resistance in myeloma refractory to both lenalidomide and bortezomib. This trial is registered at http://ClinicalTrials.gov, number NCT00558896.

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Crossref · 10.1182/blood-2011-04-348896

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  • In vitro studies support the hypothesis that thalidomide analogues synergize with dexamethasone, proteasome inhibitors, histone deacetylase inhibitors and a variety of other agents.

    “Data from a number of in vitro studies support the hypothesis that thalidomide analogues synergize with dexamethasone49,50, proteasome inhibitors51,52, histone deacetylase inhibitors53,54 and a variety of other agents”

    From Cancer therapies based on targeted protein degradation — lessons learned with lenalidomide (2021) · cites this paper as [51]

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Authors
Lacy, M. Q., Allred, J. B., Gertz, M. A., Hayman, S. R., Short, K. D., Buadi, F., Dispenzieri, A., Kumar, S., Greipp, P. R., Lust, J. A., Russell, S. J., Dingli, D., Zeldenrust, S., Fonseca, R., Bergsagel, P. L., Roy, V., Stewart, A. K., Laumann, K., Mandrekar, S. J., Reeder, C., Rajkumar, S. V., & Mikhael, J. R.
Affiliations
  • Mayo Clinic (US)
  • Mayo Clinic Arizona, Scottsdale, AZ; and
  • Mayo Clinic in Arizona (US)
  • Mayo Clinic in Florida (US)
ORCID
Venue
Blood
Publisher
American Society of Hematology
Published
2011-09-15
Volume
118
Issue
11
Pages
2970-2975
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood-2011-04-348896
PMC
PMC3291492
OpenAlex
W1973888964
Cited by
222
References
9
Citations by year
2026: 3 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 10 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 10 · 2017: 17 · 2016: 15 · 2015: 22 · 2014: 31 · 2013: 51 · 2012: 29
FWCI
26.69
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Mayo Clinic
  • Celgene
  • National Institute on Aging (R01AG020686)
  • National Cancer Institute (R01CA133966, R01CA136671)
Topics
  • Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
  • Health Sciences › Medicine › Oncology › Bone health and treatments
Keywords
pomalidomide, dexamethasone, multiple myeloma, lenalidomide-refractory myeloma, dosing regimen, myelosuppression, overall response rate, overall survival
MeSH terms
Bortezomib, Lenalidomide, Administration, Oral, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Boronic Acids, Dexamethasone, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Humans, Male, Middle Aged, Multiple Myeloma, Pyrazines, Thalidomide, Survival Analysis, Treatment Outcome, Treatment Failure, Drug Resistance, Neoplasm

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