The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
In vivo structure/function and expression analysis of the CX3C chemokine fractalkine
Open accessAbstract
The CX3C chemokine family is composed of only one member, CX3CL1, also known as fractalkine, which in mice is the sole ligand of the G protein-coupled, 7-transmembrane receptor CX3CR1. Unlike classic small peptide chemokines, CX3CL1 is synthesized as a membrane-anchored protein that can promote integrin-independent adhesion. Subsequent cleavage by metalloproteases, either constitutive or induced, can generate shed CX3CL1 entities that potentially have chemoattractive activity. To study the CX3C interface in tissues of live animals, we generated transgenic mice (CX3CL1cherry:CX3CR1gfp), which express red and green fluorescent reporter genes under the respective control of the CX3CL1 and CX3CR1 promoters. Furthermore, we performed a structure/function analysis to differentiate the in vivo functions of membrane-tethered versus shed CX3CL1 moieties by comparing their respective ability to correct established defects in macrophage function and leukocyte survival in CX3CL1-deficient mice. Specifically, expression of CX3CL1105Δ, an obligatory soluble CX3CL1 isoform, reconstituted the formation of transepithelial dendrites by intestinal macrophages but did not rescue circulating Ly6Clo CX3CR1hi blood monocytes in CX3CR1gfp/gfp mice. Instead, monocyte survival required the full-length membrane-anchored CX3CL1, suggesting differential activities of tethered and shed CX3CL1 entities.
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ATP mediates rapid microglial response to local brain injury in vivo
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Self-citationA new class of membrane-bound chemokine with a CX3C motif
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Control of microglial neurotoxicity by the fractalkine receptor
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Self-citationRegulation of Tau Pathology by the Microglial Fractalkine Receptor
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Decreased atherosclerosis in CX3CR1–/– mice reveals a role for fractalkine in atherogenesis
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Tuning inflammation and immunity by chemokine sequestration: decoys and more
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Distinct Differentiation Potential of Blood Monocyte Subsets in the Lung
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Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury
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Ensan, S., Li, A., Besla, R., Degousee, N., Cosme, J., Roufaiel, M., Shikatani, E. A., El-Maklizi, M., Williams, J. W., Robins, L., et al. (2016) · Nature Immunology · doi:10.1038/ni.3343 · Cited by 372
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Metadata
- Authors
- Kim, K.-W., Vallon-Eberhard, A., Zigmond, E., Farache, J., Shezen, E., Shakhar, G., Ludwig, A., Lira, S. A., & Jung, S.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2011-11-24
- Volume
- 118
- Issue
- 22
- Pages
- e156-e167
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2110797670
- Cited by
- 277
- References
- 10
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Kim, K.-W., Vallon-Eberhard, A., Zigmond, E., Farache, J., Shezen, E., Shakhar, G., Ludwig, A., Lira, S. A., & Jung, S. (2011). In vivo structure/function and expression analysis of the CX3C chemokine fractalkine. Blood. https://doi.org/10.1182/blood-2011-04-348946
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