Tuning inflammation and immunity by chemokine sequestration: decoys and more

Mantovani, Alberto; Bonecchi, Raffaella; Locati, Massimo

doi:10.1038/nri1964

Cited by 481Chemokine receptors and signalingImmune Response and InflammationInflammation biomarkers and pathways

Tuning inflammation and immunity by chemokine sequestration: decoys and more

Mantovani, Alberto, Bonecchi, Raffaella, Locati, Massimo·2006·Nature Reviews Immunology

DOI 10.1038/nri1964

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Abstract

A set of chemokine receptors are structurally unable to elicit migration or conventional signalling responses after ligand engagement. These 'silent' (non-signalling) chemokine receptors regulate inflammatory and immune reactions in different ways, including by acting as decoys and scavengers. Chemokine decoy receptors recognize distinct and complementary sets of ligands and are strategically expressed in different cellular contexts. Importantly, viruses and parasites have evolved multiple strategies to elude chemokines, including the expression of decoy receptors. So, decoy receptors for chemokines represent a general strategy to tune, shape and temper innate and adaptive immunity.

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Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
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Background
Chemokine signaling via the CXCR2 receptor reinforces senescence
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Chemokines and Chemokine Receptors: New Targets for Cancer Immunotherapy
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Chemokines and Their Receptors: Drug Targets in Immunity and Inflammation
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How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis?
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Resolvins and protectins in the termination program of acute inflammation
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Chemokines and Chemokine Receptors: Standing at the Crossroads of Immunobiology and Neurobiology
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Grapefruit-Derived Nanovectors Use an Activated Leukocyte Trafficking Pathway to Deliver Therapeutic Agents to Inflammatory Tumor Sites
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The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity
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How chemokines invite leukocytes to dance
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Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer
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Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin
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Capsule polysaccharide is a bacterial decoy for antimicrobial peptides
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Microbial manipulation of receptor crosstalk in innate immunity
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Mast cell–expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis
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Breast cancer lung metastasis: Molecular biology and therapeutic implications
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Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment
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Mechanisms of Regulation of the Chemokine-Receptor Network
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Tumour-infiltrating FOXP3+ lymphocytes are associated with cytotoxic immune responses and good clinical outcome in oestrogen receptor-negative breast cancer
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Postischemic Revascularization: From Cellular and Molecular Mechanisms to Clinical Applications
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Pharmacological modulation of chemokine receptor function
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Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy
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Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
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Paradoxical Roles of the Neutrophil in Sepsis: Protective and Deleterious
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Glioma infiltration and extracellular matrix: key players and modulators
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Ticks produce highly selective chemokine binding proteins with antiinflammatory activity
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Cancer‐related circulating and tumor‐associated neutrophils – subtypes, sources and function
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Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes
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New nomenclature for atypical chemokine receptors
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Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin–Yang interplay between inflammation and cancer
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Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis
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An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans
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Duffy Antigen Receptor for Chemokines Mediates trans-Infection of HIV-1 from Red Blood Cells to Target Cells and Affects HIV-AIDS Susceptibility
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Authors: Mantovani, A., Bonecchi, R., & Locati, M.
Affiliations: University of Milan (IT)
Corresponding author: Mantovani, Alberto
ORCID: Mantovani, Alberto
Bonecchi, Raffaella
Locati, Massimo
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2006-12-01
Volume: 6
Issue: 12
Pages: 907-918
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri1964
OpenAlex: W1970170374
Cited by: 481
References: 106
Citations by year: 2026: 5 · 2025: 11 · 2024: 8 · 2023: 14 · 2022: 16 · 2021: 21 · 2020: 22 · 2019: 17 · 2018: 21 · 2017: 27 · 2016: 22 · 2015: 29 · 2014: 24 · 2013: 39 · 2012: 39
FWCI: 3.10
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Ministero della Salute
Ministero dell'Università e della Ricerca
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords: chemokine receptors, leukocyte recruitment, inflammation regulation, immunomodulation, parasite evasion, innate immunity, adaptive immunity
MeSH terms: Animals, Cell Movement, Immunity, Inflammation, Parasites, Protein Conformation, Viruses, Chemokines, Receptors, Chemokine, Mice

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Tuning inflammation and immunity by chemokine sequestration: decoys and more

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