The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy
Open accessAbstract
Dendritic cells (DCs) represent a small and heterogeneous fraction of the hematopoietic system, specialized in antigen capture, processing, and presentation. The different DC subsets act as sentinels throughout the body and perform a key role in the induction of immunogenic as well as tolerogenic immune responses. Because of their limited lifespan, continuous replenishment of DC is required. Whereas the importance of GM-CSF in regulating DC homeostasis has long been underestimated, this cytokine is currently considered a critical factor for DC development under both steady-state and inflammatory conditions. Regulation of cellular actions by GM-CSF depends on the activation of intracellular signaling modules, including JAK/STAT, MAPK, PI3K, and canonical NF-κB. By directing the activity of transcription factors and other cellular effector proteins, these pathways influence differentiation, survival and/or proliferation of uncommitted hematopoietic progenitors, and DC subset–specific precursors, thereby contributing to specific aspects of DC subset development. The specific intracellular events resulting from GM-CSF–induced signaling provide a molecular explanation for GM-CSF–dependent subset distribution as well as clues to the specific characteristics and functions of GM-CSF–differentiated DCs compared with DCs generated by fms-related tyrosine kinase 3 ligand. This knowledge can be used to identify therapeutic targets to improve GM-CSF–dependent DC-based strategies to regulate immunity.
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Metadata
- Authors
- van de Laar, L., Coffer, P. J., & Woltman, A. M.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2012-04-12
- Volume
- 119
- Issue
- 15
- Pages
- 3383-3393
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1976820932
- Cited by
- 358
- References
- 118
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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