Colony stimulating factors and myeloid cell biology in health and disease

Hamilton, John A.; Achuthan, Adrian

doi:10.1016/j.it.2012.08.006

Cited by 285Cytokine Signaling Pathways and InteractionsImmune cells in cancerAcute Myeloid Leukemia Research

Colony stimulating factors and myeloid cell biology in health and disease

Hamilton, John A., Achuthan, Adrian·2013·Trends in Immunology

DOI 10.1016/j.it.2012.08.006

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Abstract

The colony stimulating factors (CSFs), granulocyte macrophage-CSF (GM-CSF), macrophage-CSF (M-CSF or CSF-1) and granulocyte-CSF (G-CSF) were first identified as in vitro hematopoietic growth factors. They have since been shown to regulate myeloid cell numbers and function at steady state and during inflammation. Preclinical data suggest that targeting CSFs might be beneficial in autoimmune and inflammatory disease, and manipulation of CSF biology is now being tested in clinical trials. Here, we examine recent insights into CSF function, at steady state and during pathology, as provided by CSF or CSF receptor neutralization/deletion studies or from CSF administration. We discuss controversies regarding the role of CSFs in controlling specific myeloid cell populations and highlight how the newly identified M-CSF receptor ligand, interleukin (IL)-34, is necessitating a reassessment of the field.

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Stress can stimulate myeloid differentiation by increasing GM-CSF, and GM-CSF signaling mediates differentiation of granulocytes and monocytes from their common progenitor GM-CFU.
“In opposition to CXCL12, stress can stimulate myeloid differentiation by increasing the myelopoietic growth factor, granulocyte-macrophage colony-stimulating factor (GM-CSF).”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Hamilton and Achuthan, 2013

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Authors: Hamilton, J. A., & Achuthan, A.
Affiliations: The Royal Melbourne Hospital (AU)
Corresponding author: Hamilton, John A.
ORCID: Hamilton, John A.
Achuthan, Adrian
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2013-02
Volume: 34
Issue: 2
Pages: 81-89
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2012.08.006
OpenAlex: W2036054943
Cited by: 285
References: 112
Citations by year: 2026: 8 · 2025: 9 · 2024: 18 · 2023: 19 · 2022: 16 · 2021: 17 · 2020: 21 · 2019: 25 · 2018: 22 · 2017: 18 · 2016: 30 · 2015: 23 · 2014: 35 · 2013: 11 · 2012: 1
FWCI: 2.30
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
Keywords: colony-stimulating factors, GM-CSF, macrophage colony-stimulating factor, CSF-1, granulocyte colony-stimulating factor, myeloid cells, hematopoietic growth factors, inflammation, autoimmune disease, IL-34
MeSH terms: Animals, Autoimmune Diseases, Cell Differentiation, Clinical Trials as Topic, Colony-Stimulating Factors, Humans, Inflammation, Granulocyte-Macrophage Colony-Stimulating Factor, Myeloid Cells, Mice

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Colony stimulating factors and myeloid cell biology in health and disease

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