The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
How I treat relapsed childhood acute lymphoblastic leukemia
Abstract
The most common cause of treatment failure in childhood acute lymphoblastic leukemia (ALL) remains relapse, occurring in ∼ 15%-20% of patients. Survival of relapsed patients can be predicted by site of relapse, length of first complete remission, and immunophenotype of relapsed ALL. BM and early relapse (< 30 months from diagnosis), as well as T-ALL, are associated with worse prognosis than isolated extramedullary or late relapse (> 30 months from diagnosis). In addition, persistence of minimal residual disease (MRD) at the end of induction or consolidation therapy predicts poor outcome because children with detectable MRD are more likely to relapse than those in molecular remission, even after allogeneic hematopoietic stem cell transplantation. We offer hematopoietic stem cell transplantation to any child with high-risk features because these patients are virtually incurable with chemotherapy alone. By contrast, we treat children with first late BM relapse of B-cell precursor ALL and good clearance of MRD with a chemotherapy approach. We use both systemic and local treatment for extramedullary relapse, mainly represented by radiotherapy and, in case of testicular involvement, by orchiectomy. Innovative approaches, including new agents or strategies of immunotherapy, are under investigation in trials enrolling patients with resistant or more advanced disease.
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Citations
Cites
Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
Ruggeri, L., Capanni, M., Urbani, E., Perruccio, K., Shlomchik, W. D., Tosti, A., Posati, S., Rogaia, D., Frassoni, F., Aversa, F., et al. (2002) · Science · doi:10.1126/science.1068440 · Cited by 3,380
Treatment of Acute Lymphoblastic Leukemia
Pui, C.-H., & Evans, W. E. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052603 · Cited by 1,976
Pui, C.-H., Robison, L. L., & Look, A. T. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60457-2 · Cited by 1,564
Tumor Regression in Cancer Patients by Very Low Doses of a T Cell–Engaging Antibody
Bargou, R., Leo, E., Zugmaier, G., Klinger, M., Goebeler, M., Knop, S., Noppeney, R., Viardot, A., Hess, G., Schuler, M., et al. (2008) · Science · doi:10.1126/science.1158545 · Cited by 1,078
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Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia
Mullighan, C. G., Phillips, L. A., Su, X., Ma, J., Miller, C. B., Shurtleff, S. A., & Downing, J. R. (2008) · Science · doi:10.1126/science.1164266 · Cited by 806
Eapen, M., Rubinstein, P., Zhang, M.-J., Stevens, C., Kurtzberg, J., Scaradavou, A., Loberiza, F. R., Champlin, R. E., Klein, J. P., Horowitz, M. M., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60915-5 · Cited by 799
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Self-citationFoà, R., Vitale, A., Vignetti, M., Meloni, G., Guarini, A., De Propris, M. S., Elia, L., Paoloni, F., Fazi, P., Cimino, G., et al. (2011) · Blood · doi:10.1182/blood-2011-05-351403 · Cited by 462
Cited by
Relapsed childhood acute lymphoblastic leukaemia
Bhojwani, D., & Pui, C.-H. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70580-6 · Cited by 414
Locatelli, F., Zugmaier, G., Rizzari, C., Morris, J. D., Gruhn, B., Klingebiel, T., Parasole, R., Linderkamp, C., Flotho, C., Petit, A., et al. (2021) · JAMA · doi:10.1001/jama.2021.0987 · Cited by 348
Self-citationLocatelli, F., Merli, P., Pagliara, D., Li Pira, G., Falco, M., Pende, D., Rondelli, R., Lucarelli, B., Brescia, L. P., Masetti, R., et al. (2017) · Blood · doi:10.1182/blood-2017-04-779769 · Cited by 316
Self-citationMartin, S., Nelson Schmitt, S., Wolters, P. L., Abel, B., Toledo-Tamula, M. A., Baldwin, A., Wicksell, R. K., Merchant, M., & Widemann, B. (2015) · Pain Medicine · doi:10.1111/pme.12620 · Cited by 48
“For example, NF1 affects approximately 1 in 3,500 people [37], and while ALL is the most common of the childhood cancers, relapsed and refractory forms of the disease occur in only 15–20% of children with the disease [38].”
Background
Metadata
- Authors
- Locatelli, F., Schrappe, M., Bernardo, M. E., & Rutella, S.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2012-10-04
- Volume
- 120
- Issue
- 14
- Pages
- 2807-2816
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2051646706
- Cited by
- 314
- References
- 60
- FWCI
- 13.31
- Type
- journal article
- Language
- en
- Open access
- closed
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