The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation
Open accessAbstract
Inorganic polyphosphate is widespread in biology and exhibits striking prohemostatic, prothrombotic, and proinflammatory effects in vivo. Long-chain polyphosphate (of the size present in infectious microorganisms) is a potent, natural pathophysiologic activator of the contact pathway of blood clotting. Medium-chain polyphosphate (of the size secreted from activated human platelets) accelerates factor V activation, completely abrogates the anticoagulant function of tissue factor pathway inhibitor, enhances fibrin clot structure, and greatly accelerates factor XI activation by thrombin. Polyphosphate may have utility as a hemostatic agent, whereas antagonists of polyphosphate may function as novel antithrombotic/anti-inflammatory agents. The detailed molecular mechanisms by which polyphosphate modulates blood clotting reactions remain to be elucidated.
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Cites
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Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo
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Cited by
Bauer, K. N., Tee, H. T., Velencoso, M. M., & Wurm, F. R. (2017) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2017.05.004 · Cited by 189
Mechanisms and management of thrombosis in cancer: Focus on gastrointestinal malignancies
Monegatti, S., Martinelli, N., Friso, S., Spronk, H. M. H., & Cate, H. T. (2025) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.124.002203 · Cited by 10
Metadata
- Authors
- Morrissey, J. H., Choi, S. H., & Smith, S. A.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2012-06-21
- Volume
- 119
- Issue
- 25
- Pages
- 5972-5979
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2079132877
- Cited by
- 375
- References
- 91
- FWCI
- 15.17
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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