The genome of the social amoeba Dictyostelium discoideum
Open accessAbstract
The social amoebae are exceptional in their ability to alternate between unicellular and multicellular forms. Here we describe the genome of the best-studied member of this group, Dictyostelium discoideum. The gene-dense chromosomes of this organism encode approximately 12,500 predicted proteins, a high proportion of which have long, repetitive amino acid tracts. There are many genes for polyketide synthases and ABC transporters, suggesting an extensive secondary metabolism for producing and exporting small molecules. The genome is rich in complex repeats, one class of which is clustered and may serve as centromeres. Partial copies of the extrachromosomal ribosomal DNA (rDNA) element are found at the ends of each chromosome, suggesting a novel telomere structure and the use of a common mechanism to maintain both the rDNA and chromosomal termini. A proteome-based phylogeny shows that the amoebozoa diverged from the animal-fungal lineage after the plant-animal split, but Dictyostelium seems to have retained more of the diversity of the ancestral genome than have plants, animals or fungi.
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The complete genome sequence of Dictyostelium has been made available recently.
“The complete genome sequence has been made available recently [28]”
From Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium (2008) · cites this paper as [28]
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- Authors
- Eichinger, L., Pachebat, J. A., Glöckner, G., Rajandream, M.-A., Sucgang, R., Berriman, M., Song, J., Olsen, R., Szafranski, K., Xu, Q., Tunggal, B., Kummerfeld, S., Madera, M., Konfortov, B. A., Rivero, F., Bankier, A. T., Lehmann, R., Hamlin, N., Davies, R., Gaudet, P., Fey, P., Pilcher, K., Chen, G., Saunders, D., Sodergren, E., Davis, P., Kerhornou, A., Nie, X., Hall, N., Anjard, C., Hemphill, L., Bason, N., Farbrother, P., Desany, B., Just, E., Morio, T., Rost, R., Churcher, C., Cooper, J., Haydock, S., van Driessche, N., Cronin, A., Goodhead, I., Muzny, D., Mourier, T., Pain, A., Lu, M., Harper, D., Lindsay, R., Hauser, H., James, K., Quiles, M., Madan Babu, M., Saito, T., Buchrieser, C., Wardroper, A., Felder, M., Thangavelu, M., Johnson, D., Knights, A., Loulseged, H., Mungall, K., Oliver, K., Price, C., Quail, M. A., Urushihara, H., Hernandez, J., Rabbinowitsch, E., Steffen, D., Sanders, M., Ma, J., Kohara, Y., Sharp, S., Simmonds, M., Spiegler, S., Tivey, A., Sugano, S., White, B., Walker, D., Woodward, J., Winckler, T., Tanaka, Y., Shaulsky, G., Schleicher, M., Weinstock, G., Rosenthal, A., Cox, E. C., Chisholm, R. L., Gibbs, R., Loomis, W. F., Platzer, M., Kay, R. R., Williams, J., Dear, P. H., Noegel, A. A., Barrell, B., & Kuspa, A.
- Affiliations
- University of Cologne (DE)
- MRC Laboratory of Molecular Biology (GB)
- Wellcome Sanger Institute (GB)
- Baylor College of Medicine (US)
- University of California San Diego (US)
- Northwestern University (US)
- University of Tsukuba (JP)
- Adolf-Butenandt-Institut für Physiologische Chemie, Physikalische Biochemie und Zellbiologie (DE)
- University of Cambridge (GB)
- Hokkaido University (JP)
- Institut Pasteur (FR)
- MRC Cancer Unit (GB)
- National Institute of Genetics (JP)
- The University of Tokyo (JP)
- Goethe University Frankfurt (DE)
- University of Dundee (GB)
- Corresponding author
- Dear, P. H.
- ORCID
- Eichinger, L.
- Pachebat, J. A.
- Glöckner, G.
- Berriman, M.
- Song, J.
- Szafranski, K.
- Xu, Q.
- Kummerfeld, S.
- Rivero, F.
- Davies, R.
- Gaudet, P.
- Fey, P.
- Saunders, D.
- Sodergren, E.
- Davis, P.
- Kerhornou, A.
- Hall, N.
- Anjard, C.
- Morio, T.
- Rost, R.
- Cooper, J.
- Goodhead, I.
- Muzny, D.
- Mourier, T.
- Pain, A.
- Harper, D.
- Saito, T.
- Buchrieser, C.
- Knights, A.
- Mungall, K.
- Oliver, K.
- Price, C.
- Quail, M. A.
- Hernandez, J.
- Steffen, D.
- Ma, J.
- Kohara, Y.
- Sharp, S.
- Spiegler, S.
- Tivey, A.
- Sugano, S.
- Winckler, T.
- Shaulsky, G.
- Weinstock, G.
- Chisholm, R. L.
- Gibbs, R.
- Platzer, M.
- Kay, R. R.
- Noegel, A. A.
- Kuspa, A.
- Venue
- Nature
- Published
- 2005-05-05
- Volume
- 435
- Issue
- 7038
- Pages
- 43-57
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC1352341
- OpenAlex
- W2074308942
- Cited by
- 1,351
- References
- 5
- Citations by year
- 2026: 29 · 2025: 35 · 2024: 34 · 2023: 29 · 2022: 46 · 2021: 61 · 2020: 50 · 2019: 58 · 2018: 55 · 2017: 53 · 2016: 55 · 2015: 54 · 2014: 63 · 2013: 82 · 2012: 53
- FWCI
- 42.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- University of Dundee
- Wellcome Trust
- European Commission
- Deutsche Forschungsgemeinschaft
- Ministry of Education, Culture, Sports, Science and Technology
- National Institutes of Health
- Medical Research Council
- Japan Society for the Promotion of Science
- National Institute of General Medical Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD035925)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protist diversity and phylogeny
- Physical Sciences › Engineering › Biomedical Engineering › Slime Mold and Myxomycetes Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- Dictyostelium discoideum, genome sequence, social amoebae, Amoebozoa, multicellularity, cell differentiation, polyketide synthase, ABC transporters, secondary metabolism, centromere, telomere structure, eukaryotic origin, eukaryotic diversification
- MeSH terms
- Animals, Base Composition, Cell Adhesion, Cell Movement, Centromere, Dictyostelium, DNA Transposable Elements, DNA, Ribosomal, Eukaryotic Cells, Humans, Molecular Sequence Data, Phylogeny, Repetitive Sequences, Nucleic Acid, RNA, Transfer, Social Behavior, Signal Transduction, Protozoan Proteins, Telomere, Genome, Conserved Sequence, Sequence Analysis, DNA, ATP-Binding Cassette Transporters, Gene Duplication, Proteome, Gene Transfer, Horizontal, Genomics
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