CoChat
Sign Up
Cited by 270T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells

Open access
Tewalt, Eric F., Cohen, Jarish N., Rouhani, Sherin J., Guidi, Cynthia J., Qiao, Hui, Fahl, Shawn P., Conaway, Mark R., Bender, Timothy P. +5 more·2012·Blood
DOI 10.1182/blood-2012-04-427013PMC PMC3520619
Open this paper in CoChat — free account

Abstract

Lymphatic endothelial cells (LECs) induce peripheral tolerance by direct presentation to CD8 T cells (TCD8). We demonstrate that LECs mediate deletion only via programmed cell death-1 (PD-1) ligand 1, despite expressing ligands for the CD160, B- and T-lymphocyte attenuator, and lymphocyte activation gene-3 inhibitory pathways. LECs induce activation and proliferation of TCD8, but lack of costimulation through 4-1BB leads to rapid high-level expression of PD-1, which in turn inhibits up-regulation of the high-affinity IL-2 receptor that is necessary for TCD8 survival. Rescue of tyrosinase-specific TCD8 by interference with PD-1 or provision of costimulation results in autoimmune vitiligo, demonstrating that LECs are significant, albeit suboptimal, antigen-presenting cells. Because LECs express numerous peripheral tissue antigens, lack of costimulation coupled to rapid high-level up-regulation of inhibitory receptors may be generally important in systemic peripheral tolerance.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1182/blood-2012-04-427013

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • LECs can directly present antigens on MHC class I to CD8 T cells.

    “Last, several studies have indicated that LECs themselves can directly present antigens on major histocompatibility complex class I to CD8 T cells (128–130).”

    From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [129]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 49

  1. [1]Harding FA, McArthur JG, Gross JA, Raulet DH, Allison JP. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature. 1992;356(6370):607–609. doi: 10.1038/356607a0. [[DOI](https://doi.org/10.1038/356607a0)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/1313950/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Nature&title=CD28-mediated%20signalling%20co-stimulates%20murine%20T%20cells%20and%20prevents%20induction%20of%20anergy%20in%20T-cell%20clones.&author=FA%20Harding&author=JG%20McArthur&author=JA%20Gross&author=DH%20Raulet&author=JP%20Allison&volume=356&issue=6370&publication_year=1992&pages=607-609&pmid=1313950&doi=10.1038/356607a0&)] · DOI
  2. [2]Hawiger D, Inaba K, Dorsett Y, et al. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med. 2001;194(6):769–779. doi: 10.1084/jem.194.6.769. [[DOI](https://doi.org/10.1084/jem.194.6.769)] [[PMC free article](/articles/PMC2195961/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/11560993/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Exp%20Med&title=Dendritic%20cells%20induce%20peripheral%20T%20cell%20unresponsiveness%20under%20steady%20state%20conditions%20in%20vivo.&author=D%20Hawiger&author=K%20Inaba&author=Y%20Dorsett&volume=194&issue=6&publication_year=2001&pages=769-779&pmid=11560993&doi=10.1084/jem.194.6.769&)] · DOI
  3. [3]Hernandez J, Aung S, Marquardt K, Sherman LA. Uncoupling of proliferative potential and gain of effector function by CD8(+) T cells responding to self-antigens. J Exp Med. 2002;196(3):323–333. doi: 10.1084/jem.20011612. [[DOI](https://doi.org/10.1084/jem.20011612)] [[PMC free article](/articles/PMC2193940/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/12163561/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Exp%20Med&title=Uncoupling%20of%20proliferative%20potential%20and%20gain%20of%20effector%20function%20by%20CD8(+)%20T%20cells%20responding%20to%20self-antigens.&author=J%20Hernandez&author=S%20Aung&author=K%20Marquardt&author=LA%20Sherman&volume=196&issue=3&publication_year=2002&pages=323-333&pmid=12163561&doi=10.1084/jem.20011612&)] · DOI
  4. [4]Albert ML, Jegathesan M, Darnell RB. Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells. Nat Immunol. 2001;2(11):1010–1017. doi: 10.1038/ni722. [[DOI](https://doi.org/10.1038/ni722)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/11590405/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Nat%20Immunol&title=Dendritic%20cell%20maturation%20is%20required%20for%20the%20cross-tolerization%20of%20CD8+%20T%20cells.&author=ML%20Albert&author=M%20Jegathesan&author=RB%20Darnell&volume=2&issue=11&publication_year=2001&pages=1010-1017&pmid=11590405&doi=10.1038/ni722&)] · DOI
  5. [5]Vacchio MS, Hodes RJ. CD28 costimulation is required for in vivo induction of peripheral tolerance in CD8 T cells. J Exp Med. 2003;197(1):19–26. doi: 10.1084/jem.20021429. [[DOI](https://doi.org/10.1084/jem.20021429)] [[PMC free article](/articles/PMC2193800/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/12515810/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Exp%20Med&title=CD28%20costimulation%20is%20required%20for%20in%20vivo%20induction%20of%20peripheral%20tolerance%20in%20CD8%20T%20cells.&author=MS%20Vacchio&author=RJ%20Hodes&volume=197&issue=1&publication_year=2003&pages=19-26&pmid=12515810&doi=10.1084/jem.20021429&)] · DOI
  6. [6]Keller AM, Schildknecht A, Xiao Y, van den Broek M, Borst J. Expression of costimulatory ligand CD70 on steady-state dendritic cells breaks CD8+ T cell tolerance and permits effective immunity. Immunity. 2008;29(6):934–946. doi: 10.1016/j.immuni.2008.10.009. [[DOI](https://doi.org/10.1016/j.immuni.2008.10.009)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/19062317/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Immunity&title=Expression%20of%20costimulatory%20ligand%20CD70%20on%20steady-state%20dendritic%20cells%20breaks%20CD8+%20T%20cell%20tolerance%20and%20permits%20effective%20immunity.&author=AM%20Keller&author=A%20Schildknecht&author=Y%20Xiao&author=M%20van%20den%20Broek&author=J%20Borst&volume=29&issue=6&publication_year=2008&pages=934-946&pmid=19062317&doi=10.1016/j.immuni.2008.10.009&)] · DOI
  7. [7]Bandyopadhyay S, Long M, Qui HZ, et al. Self-antigen prevents CD8 T cell effector differentiation by CD134 and CD137 dual costimulation. J Immunol. 2008;181(11):7728–7737. doi: 10.4049/jimmunol.181.11.7728. [[DOI](https://doi.org/10.4049/jimmunol.181.11.7728)] [[PMC free article](/articles/PMC2846364/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/19017962/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Immunol&title=Self-antigen%20prevents%20CD8%20T%20cell%20effector%20differentiation%20by%20CD134%20and%20CD137%20dual%20costimulation.&author=S%20Bandyopadhyay&author=M%20Long&author=HZ%20Qui&volume=181&issue=11&publication_year=2008&pages=7728-7737&pmid=19017962&doi=10.4049/jimmunol.181.11.7728&)] · DOI
  8. [8]Thompson CB, Lindsten T, Ledbetter JA, et al. CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc Natl Acad Sci U S A. 1989;86(4):1333–1337. doi: 10.1073/pnas.86.4.1333. [[DOI](https://doi.org/10.1073/pnas.86.4.1333)] [[PMC free article](/articles/PMC286684/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/2465550/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&title=CD28%20activation%20pathway%20regulates%20the%20production%20of%20multiple%20T-cell-derived%20lymphokines/cytokines.&author=CB%20Thompson&author=T%20Lindsten&author=JA%20Ledbetter&volume=86&issue=4&publication_year=1989&pages=1333-1337&pmid=2465550&doi=10.1073/pnas.86.4.1333&)] · DOI
  9. [9]Peperzak V, Xiao Y, Veraar EA, Borst J. CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production. J Clin Invest. 2010;120(1):168–178. doi: 10.1172/JCI40178. [[DOI](https://doi.org/10.1172/JCI40178)] [[PMC free article](/articles/PMC2798690/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/19955658/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Clin%20Invest&title=CD27%20sustains%20survival%20of%20CTLs%20in%20virus-infected%20nonlymphoid%20tissue%20in%20mice%20by%20inducing%20autocrine%20IL-2%20production.&author=V%20Peperzak&author=Y%20Xiao&author=EA%20Veraar&author=J%20Borst&volume=120&issue=1&publication_year=2010&pages=168-178&pmid=19955658&doi=10.1172/JCI40178&)] · DOI
  10. [10]Rogers PR, Song J, Gramaglia I, Killeen N, Croft M. OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity. 2001;15(3):445–455. doi: 10.1016/s1074-7613(01)00191-1. [[DOI](https://doi.org/10.1016/s1074-7613(01)00191-1)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/11567634/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Immunity&title=OX40%20promotes%20Bcl-xL%20and%20Bcl-2%20expression%20and%20is%20essential%20for%20long-term%20survival%20of%20CD4%20T%20cells.&author=PR%20Rogers&author=J%20Song&author=I%20Gramaglia&author=N%20Killeen&author=M%20Croft&volume=15&issue=3&publication_year=2001&pages=445-455&pmid=11567634&doi=10.1016/s1074-7613(01)00191-1&)] · DOI
  11. [11]Saoulli K, Lee SY, Cannons JL, et al. CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand. J Exp Med. 1998;187(11):1849–1862. doi: 10.1084/jem.187.11.1849. [[DOI](https://doi.org/10.1084/jem.187.11.1849)] [[PMC free article](/articles/PMC2212301/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/9607925/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Exp%20Med&title=CD28-independent,%20TRAF2-dependent%20costimulation%20of%20resting%20T%20cells%20by%204-1BB%20ligand.&author=K%20Saoulli&author=SY%20Lee&author=JL%20Cannons&volume=187&issue=11&publication_year=1998&pages=1849-1862&pmid=9607925&doi=10.1084/jem.187.11.1849&)] · DOI
  12. [12]Boise LH, Minn AJ, Noel PJ, et al. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL. Immunity. 1995;3(1):87–98. doi: 10.1016/1074-7613(95)90161-2. [[DOI](https://doi.org/10.1016/1074-7613(95)90161-2)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/7621080/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Immunity&title=CD28%20costimulation%20can%20promote%20T%20cell%20survival%20by%20enhancing%20the%20expression%20of%20Bcl-xL.&author=LH%20Boise&author=AJ%20Minn&author=PJ%20Noel&volume=3&issue=1&publication_year=1995&pages=87-98&pmid=7621080&doi=10.1016/1074-7613(95)90161-2&)] · DOI
  13. [13]van Oosterwijk MF, Juwana H, Arens R, et al. CD27-CD70 interactions sensitise naive CD4+ T cells for IL-12-induced Th1 cell development. Int Immunol. 2007;19(6):713–718. doi: 10.1093/intimm/dxm033. [[DOI](https://doi.org/10.1093/intimm/dxm033)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/17548342/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Int%20Immunol&title=CD27-CD70%20interactions%20sensitise%20naive%20CD4+%20T%20cells%20for%20IL-12-induced%20Th1%20cell%20development.&author=MF%20van%20Oosterwijk&author=H%20Juwana&author=R%20Arens&volume=19&issue=6&publication_year=2007&pages=713-718&pmid=17548342&doi=10.1093/intimm/dxm033&)] · DOI
  14. [14]Lee HW, Park SJ, Choi BK, Kim HH, Nam KO, Kwon BS. 4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1. J Immunol. 2002;169(9):4882–4888. doi: 10.4049/jimmunol.169.9.4882. [[DOI](https://doi.org/10.4049/jimmunol.169.9.4882)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/12391199/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Immunol&title=4-1BB%20promotes%20the%20survival%20of%20CD8+%20T%20lymphocytes%20by%20increasing%20expression%20of%20Bcl-xL%20and%20Bfl-1.&author=HW%20Lee&author=SJ%20Park&author=BK%20Choi&author=HH%20Kim&author=KO%20Nam&volume=169&issue=9&publication_year=2002&pages=4882-4888&pmid=12391199&doi=10.4049/jimmunol.169.9.4882&)] · DOI
  15. [15]Nurieva R, Thomas S, Nguyen T, et al. T-cell tolerance or function is determined by combinatorial costimulatory signals. EMBO J. 2006;25(11):2623–2633. doi: 10.1038/sj.emboj.7601146. [[DOI](https://doi.org/10.1038/sj.emboj.7601146)] [[PMC free article](/articles/PMC1478197/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/16724117/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=EMBO%20J&title=T-cell%20tolerance%20or%20function%20is%20determined%20by%20combinatorial%20costimulatory%20signals.&author=R%20Nurieva&author=S%20Thomas&author=T%20Nguyen&volume=25&issue=11&publication_year=2006&pages=2623-2633&pmid=16724117&doi=10.1038/sj.emboj.7601146&)] · DOI
  16. [16]Goldberg MV, Maris CH, Hipkiss EL, et al. Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells. Blood. 2007;110(1):186–192. doi: 10.1182/blood-2006-12-062422. [[DOI](https://doi.org/10.1182/blood-2006-12-062422)] [[PMC free article](/articles/PMC1896112/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/17392506/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Blood&title=Role%20of%20PD-1%20and%20its%20ligand,%20B7-H1,%20in%20early%20fate%20decisions%20of%20CD8%20T%20cells.&author=MV%20Goldberg&author=CH%20Maris&author=EL%20Hipkiss&volume=110&issue=1&publication_year=2007&pages=186-192&pmid=17392506&doi=10.1182/blood-2006-12-062422&)] · DOI
  17. [17]Reynoso ED, Elpek KG, Francisco L, et al. Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade. J Immunol. 2009;182(4):2102–2112. doi: 10.4049/jimmunol.0802769. [[DOI](https://doi.org/10.4049/jimmunol.0802769)] [[PMC free article](/articles/PMC3682217/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/19201863/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Immunol&title=Intestinal%20tolerance%20is%20converted%20to%20autoimmune%20enteritis%20upon%20PD-1%20ligand%20blockade.&author=ED%20Reynoso&author=KG%20Elpek&author=L%20Francisco&volume=182&issue=4&publication_year=2009&pages=2102-2112&pmid=19201863&doi=10.4049/jimmunol.0802769&)] · DOI
  18. [18]Martin-Orozco N, Wang YH, Yagita H, Dong C. Cutting edge: programmed death (PD) ligand-1/PD-1 interaction is required for CD8+ T cell tolerance to tissue antigens. J Immunol. 2006;177(12):8291–8295. doi: 10.4049/jimmunol.177.12.8291. [[DOI](https://doi.org/10.4049/jimmunol.177.12.8291)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/17142723/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Immunol&title=Cutting%20edge:%20programmed%20death%20(PD)%20ligand-1/PD-1%20interaction%20is%20required%20for%20CD8+%20T%20cell%20tolerance%20to%20tissue%20antigens.&author=N%20Martin-Orozco&author=YH%20Wang&author=H%20Yagita&author=C%20Dong&volume=177&issue=12&publication_year=2006&pages=8291-8295&pmid=17142723&doi=10.4049/jimmunol.177.12.8291&)] · DOI
  19. [19]Liu X, Alexiou M, Martin-Orozco N, et al. Cutting edge: a critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction. J Immunol. 2009;182(8):4516–4520. doi: 10.4049/jimmunol.0803161. [[DOI](https://doi.org/10.4049/jimmunol.0803161)] [[PMC free article](/articles/PMC2767106/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/19342624/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Immunol&title=Cutting%20edge:%20a%20critical%20role%20of%20B%20and%20T%20lymphocyte%20attenuator%20in%20peripheral%20T%20cell%20tolerance%20induction.&author=X%20Liu&author=M%20Alexiou&author=N%20Martin-Orozco&volume=182&issue=8&publication_year=2009&pages=4516-4520&pmid=19342624&doi=10.4049/jimmunol.0803161&)] · DOI
  20. [20]Tsushima F, Yao S, Shin T, et al. Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy. Blood. 2007;110(1):180–185. doi: 10.1182/blood-2006-11-060087. [[DOI](https://doi.org/10.1182/blood-2006-11-060087)] [[PMC free article](/articles/PMC1896111/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/17289811/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Blood&title=Interaction%20between%20B7-H1%20and%20PD-1%20determines%20initiation%20and%20reversal%20of%20T-cell%20anergy.&author=F%20Tsushima&author=S%20Yao&author=T%20Shin&volume=110&issue=1&publication_year=2007&pages=180-185&pmid=17289811&doi=10.1182/blood-2006-11-060087&)] · DOI
  21. [21]Grosso JF, Kelleher CC, Harris TJ, et al. LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems. J Clin Invest. 2007;117(11):3383–3392. doi: 10.1172/JCI31184. [[DOI](https://doi.org/10.1172/JCI31184)] [[PMC free article](/articles/PMC2000807/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/17932562/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Clin%20Invest&title=LAG-3%20regulates%20CD8+%20T%20cell%20accumulation%20and%20effector%20function%20in%20murine%20self-%20and%20tumor-tolerance%20systems.&author=JF%20Grosso&author=CC%20Kelleher&author=TJ%20Harris&volume=117&issue=11&publication_year=2007&pages=3383-3392&pmid=17932562&doi=10.1172/JCI31184&)] · DOI
  22. [22]Workman CJ, Vignali DA. The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells. Eur J Immunol. 2003;33(4):970–979. doi: 10.1002/eji.200323382. [[DOI](https://doi.org/10.1002/eji.200323382)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/12672063/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Eur%20J%20Immunol&title=The%20CD4-related%20molecule,%20LAG-3%20(CD223),%20regulates%20the%20expansion%20of%20activated%20T%20cells.&author=CJ%20Workman&author=DA%20Vignali&volume=33&issue=4&publication_year=2003&pages=970-979&pmid=12672063&doi=10.1002/eji.200323382&)] · DOI
  23. [23]Parry RV, Chemnitz JM, Frauwirth KA, et al. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol Cell Biol. 2005;25(21):9543–9553. doi: 10.1128/MCB.25.21.9543-9553.2005. [[DOI](https://doi.org/10.1128/MCB.25.21.9543-9553.2005)] [[PMC free article](/articles/PMC1265804/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/16227604/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Mol%20Cell%20Biol&title=CTLA-4%20and%20PD-1%20receptors%20inhibit%20T-cell%20activation%20by%20distinct%20mechanisms.&author=RV%20Parry&author=JM%20Chemnitz&author=KA%20Frauwirth&volume=25&issue=21&publication_year=2005&pages=9543-9553&pmid=16227604&doi=10.1128/MCB.25.21.9543-9553.2005&)] · DOI · Paper page
  24. [24]Watanabe N, Gavrieli M, Sedy JR, et al. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol. 2003;4(7):670–679. doi: 10.1038/ni944. [[DOI](https://doi.org/10.1038/ni944)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/12796776/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Nat%20Immunol&title=BTLA%20is%20a%20lymphocyte%20inhibitory%20receptor%20with%20similarities%20to%20CTLA-4%20and%20PD-1.&author=N%20Watanabe&author=M%20Gavrieli&author=JR%20Sedy&volume=4&issue=7&publication_year=2003&pages=670-679&pmid=12796776&doi=10.1038/ni944&)] · DOI · Paper page
  25. [25]Belz GT, Behrens GM, Smith CM, et al. The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens. J Exp Med. 2002;196(8):1099–1104. doi: 10.1084/jem.20020861. [[DOI](https://doi.org/10.1084/jem.20020861)] [[PMC free article](/articles/PMC2194045/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/12391021/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Exp%20Med&title=The%20CD8alpha(+)%20dendritic%20cell%20is%20responsible%20for%20inducing%20peripheral%20self-tolerance%20to%20tissue-associated%20antigens.&author=GT%20Belz&author=GM%20Behrens&author=CM%20Smith&volume=196&issue=8&publication_year=2002&pages=1099-1104&pmid=12391021&doi=10.1084/jem.20020861&)] · DOI
  26. [26]Gardner JM, Devoss JJ, Friedman RS, et al. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science. 2008;321(5890):843–847. doi: 10.1126/science.1159407. [[DOI](https://doi.org/10.1126/science.1159407)] [[PMC free article](/articles/PMC2532844/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/18687966/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Science&title=Deletional%20tolerance%20mediated%20by%20extrathymic%20Aire-expressing%20cells.&author=JM%20Gardner&author=JJ%20Devoss&author=RS%20Friedman&volume=321&issue=5890&publication_year=2008&pages=843-847&pmid=18687966&doi=10.1126/science.1159407&)] · DOI
  27. [27]Fletcher AL, Lukacs-Kornek V, Reynoso ED, et al. Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions. J Exp Med. 2010;207(4):689–697. doi: 10.1084/jem.20092642. [[DOI](https://doi.org/10.1084/jem.20092642)] [[PMC free article](/articles/PMC2856033/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/20308362/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Exp%20Med&title=Lymph%20node%20fibroblastic%20reticular%20cells%20directly%20present%20peripheral%20tissue%20antigen%20under%20steady-state%20and%20inflammatory%20conditions.&author=AL%20Fletcher&author=V%20Lukacs-Kornek&author=ED%20Reynoso&volume=207&issue=4&publication_year=2010&pages=689-697&pmid=20308362&doi=10.1084/jem.20092642&)] · DOI
  28. [28]Cohen JN, Guidi CJ, Tewalt EF, et al. Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation. J Exp Med. 2010;207(4):681–688. doi: 10.1084/jem.20092465. [[DOI](https://doi.org/10.1084/jem.20092465)] [[PMC free article](/articles/PMC2856027/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/20308365/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Exp%20Med&title=Lymph%20node-resident%20lymphatic%20endothelial%20cells%20mediate%20peripheral%20tolerance%20via%20Aire-independent%20direct%20antigen%20presentation.&author=JN%20Cohen&author=CJ%20Guidi&author=EF%20Tewalt&volume=207&issue=4&publication_year=2010&pages=681-688&pmid=20308365&doi=10.1084/jem.20092465&)] · DOI
  29. [29]Colella TA, Bullock TNJ, Russell LB, et al. Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy. J Exp Med. 2000;191(7):1221–1231. doi: 10.1084/jem.191.7.1221. [[DOI](https://doi.org/10.1084/jem.191.7.1221)] [[PMC free article](/articles/PMC2193167/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/10748239/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Exp%20Med&title=Self-tolerance%20to%20the%20murine%20homologue%20of%20a%20tyrosinase-derived%20melanoma%20antigen:%20implications%20for%20tumor%20immunotherapy.&author=TA%20Colella&author=TNJ%20Bullock&author=LB%20Russell&volume=191&issue=7&publication_year=2000&pages=1221-1231&pmid=10748239&doi=10.1084/jem.191.7.1221&)] · DOI
  30. [30]Nichols LA, Chen Y, Colella TA, Bennet CL, Clausen BE, Engelhard VH. Deletional self-tolerance to a melancyte/melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodes. J Immunol. 2007;179(2):993–1003. doi: 10.4049/jimmunol.179.2.993. [[DOI](https://doi.org/10.4049/jimmunol.179.2.993)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/17617591/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Immunol&title=Deletional%20self-tolerance%20to%20a%20melancyte/melanoma%20antigen%20derived%20from%20tyrosinase%20is%20mediated%20by%20a%20radio-resistant%20cell%20in%20peripheral%20and%20mesenteric%20lymph%20nodes.&author=LA%20Nichols&author=Y%20Chen&author=TA%20Colella&author=CL%20Bennet&author=BE%20Clausen&volume=179&issue=2&publication_year=2007&pages=993-1003&pmid=17617591&doi=10.4049/jimmunol.179.2.993&)] · DOI
  31. [32]Park JJ, Omiya R, Matsumura Y, et al. B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance. Blood. 2010;116(8):1291–1298. doi: 10.1182/blood-2010-01-265975. [[DOI](https://doi.org/10.1182/blood-2010-01-265975)] [[PMC free article](/articles/PMC2938239/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/20472828/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Blood&title=B7-H1/CD80%20interaction%20is%20required%20for%20the%20induction%20and%20maintenance%20of%20peripheral%20T-cell%20tolerance.&author=JJ%20Park&author=R%20Omiya&author=Y%20Matsumura&volume=116&issue=8&publication_year=2010&pages=1291-1298&pmid=20472828&doi=10.1182/blood-2010-01-265975&)] · DOI
  32. [33]Tao R, Wang L, Han R, et al. Differential effects of B and T lymphocyte attenuator and programmed death-1 on acceptance of partially versus fully MHC-mismatched cardiac allografts. J Immunol. 2005;175(9):5774–5782. doi: 10.4049/jimmunol.175.9.5774. [[DOI](https://doi.org/10.4049/jimmunol.175.9.5774)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/16237069/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Immunol&title=Differential%20effects%20of%20B%20and%20T%20lymphocyte%20attenuator%20and%20programmed%20death-1%20on%20acceptance%20of%20partially%20versus%20fully%20MHC-mismatched%20cardiac%20allografts.&author=R%20Tao&author=L%20Wang&author=R%20Han&volume=175&issue=9&publication_year=2005&pages=5774-5782&pmid=16237069&doi=10.4049/jimmunol.175.9.5774&)] · DOI
  33. [34]Blackburn SD, Shin H, Haining WN, et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol. 2009;10(1):29–37. doi: 10.1038/ni.1679. [[DOI](https://doi.org/10.1038/ni.1679)] [[PMC free article](/articles/PMC2605166/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/19043418/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Nat%20Immunol&title=Coregulation%20of%20CD8+%20T%20cell%20exhaustion%20by%20multiple%20inhibitory%20receptors%20during%20chronic%20viral%20infection.&author=SD%20Blackburn&author=H%20Shin&author=WN%20Haining&volume=10&issue=1&publication_year=2009&pages=29-37&pmid=19043418&doi=10.1038/ni.1679&)] · DOI · Paper page
  34. [35]Barber DL, Wherry EJ, Masopust D, et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 2006;439(7077):682–687. doi: 10.1038/nature04444. [[DOI](https://doi.org/10.1038/nature04444)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/16382236/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Nature&title=Restoring%20function%20in%20exhausted%20CD8%20T%20cells%20during%20chronic%20viral%20infection.&author=DL%20Barber&author=EJ%20Wherry&author=D%20Masopust&volume=439&issue=7077&publication_year=2006&pages=682-687&pmid=16382236&doi=10.1038/nature04444&)] · DOI
  35. [36]Sheppard KA, Fitz LJ, Lee JM, et al. PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta. FEBS Lett. 2004;574(1-3):37–41. doi: 10.1016/j.febslet.2004.07.083. [[DOI](https://doi.org/10.1016/j.febslet.2004.07.083)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/15358536/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=FEBS%20Lett&title=PD-1%20inhibits%20T-cell%20receptor%20induced%20phosphorylation%20of%20the%20ZAP70/CD3zeta%20signalosome%20and%20downstream%20signaling%20to%20PKCtheta.&author=KA%20Sheppard&author=LJ%20Fitz&author=JM%20Lee&volume=574&issue=1-3&publication_year=2004&pages=37-41&pmid=15358536&doi=10.1016/j.febslet.2004.07.083&)] · DOI · Paper page
  36. [37]Carter L, Fouser LA, Jussif J, et al. PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2. Eur J Immunol. 2002;32(3):634–643. doi: 10.1002/1521-4141(200203)32:3<634::AID-IMMU634>3.0.CO;2-9. [[DOI](https://doi.org/10.1002/1521-4141(200203)32:3<634::AID-IMMU634>3.0.CO;2-9)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/11857337/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Eur%20J%20Immunol&title=PD-1:PD-L%20inhibitory%20pathway%20affects%20both%20CD4(+)%20and%20CD8(+)%20T%20cells%20and%20is%20overcome%20by%20IL-2.&author=L%20Carter&author=LA%20Fouser&author=J%20Jussif&volume=32&issue=3&publication_year=2002&pages=634-643&pmid=11857337&doi=10.1002/1521-4141(200203)32:3<634::AID-IMMU634>3.0.CO;2-9&)] · DOI
  37. [38]Chemnitz JM, Parry RV, Nichols KE, June CH, Riley JL. SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation. J Immunol. 2004;173(2):945–954. doi: 10.4049/jimmunol.173.2.945. [[DOI](https://doi.org/10.4049/jimmunol.173.2.945)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/15240681/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Immunol&title=SHP-1%20and%20SHP-2%20associate%20with%20immunoreceptor%20tyrosine-based%20switch%20motif%20of%20programmed%20death%201%20upon%20primary%20human%20T%20cell%20stimulation,%20but%20only%20receptor%20ligation%20prevents%20T%20cell%20activation.&author=JM%20Chemnitz&author=RV%20Parry&author=KE%20Nichols&author=CH%20June&author=JL%20Riley&volume=173&issue=2&publication_year=2004&pages=945-954&pmid=15240681&doi=10.4049/jimmunol.173.2.945&)] · DOI · Paper page
  38. [39]Chikuma S, Terawaki S, Hayashi T, et al. PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo. J Immunol. 2009;182(11):6682–6689. doi: 10.4049/jimmunol.0900080. [[DOI](https://doi.org/10.4049/jimmunol.0900080)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/19454662/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Immunol&title=PD-1-mediated%20suppression%20of%20IL-2%20production%20induces%20CD8+%20T%20cell%20anergy%20in%20vivo.&author=S%20Chikuma&author=S%20Terawaki&author=T%20Hayashi&volume=182&issue=11&publication_year=2009&pages=6682-6689&pmid=19454662&doi=10.4049/jimmunol.0900080&)] · DOI
  39. [40]D'Souza WN, Lefrancois L. IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion. J Immunol. 2003;171(11):5727–5735. doi: 10.4049/jimmunol.171.11.5727. [[DOI](https://doi.org/10.4049/jimmunol.171.11.5727)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/14634080/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Immunol&title=IL-2%20is%20not%20required%20for%20the%20initiation%20of%20CD8%20T%20cell%20cycling%20but%20sustains%20expansion.&author=WN%20D'Souza&author=L%20Lefrancois&volume=171&issue=11&publication_year=2003&pages=5727-5735&pmid=14634080&doi=10.4049/jimmunol.171.11.5727&)] · DOI
  40. [41]Lee JW, Epardaud M, Sun J, et al. Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat Immunol. 2007;8(2):181–190. doi: 10.1038/ni1427. [[DOI](https://doi.org/10.1038/ni1427)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/17195844/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Nat%20Immunol&title=Peripheral%20antigen%20display%20by%20lymph%20node%20stroma%20promotes%20T%20cell%20tolerance%20to%20intestinal%20self.&author=JW%20Lee&author=M%20Epardaud&author=J%20Sun&volume=8&issue=2&publication_year=2007&pages=181-190&pmid=17195844&doi=10.1038/ni1427&)] · DOI
  41. [42]Khan O, Headley M, Gerard A, Wei W, Liu L, Krummel MF. Regulation of T cell priming by lymphoid stroma. PLoS ONE. 2011;6(11):e26138. doi: 10.1371/journal.pone.0026138. [[DOI](https://doi.org/10.1371/journal.pone.0026138)] [[PMC free article](/articles/PMC3215700/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/22110583/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=PLoS%20ONE&title=Regulation%20of%20T%20cell%20priming%20by%20lymphoid%20stroma.&author=O%20Khan&author=M%20Headley&author=A%20Gerard&author=W%20Wei&author=L%20Liu&volume=6&issue=11&publication_year=2011&pages=e26138&pmid=22110583&doi=10.1371/journal.pone.0026138&)] · DOI
  42. [43]Lukacs-Kornek V, Malhotra D, Fletcher AL, et al. Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes. Nat Immunol. 2011;12(11):1096–1104. doi: 10.1038/ni.2112. [[DOI](https://doi.org/10.1038/ni.2112)] [[PMC free article](/articles/PMC3457791/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/21926986/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Nat%20Immunol&title=Regulated%20release%20of%20nitric%20oxide%20by%20nonhematopoietic%20stroma%20controls%20expansion%20of%20the%20activated%20T%20cell%20pool%20in%20lymph%20nodes.&author=V%20Lukacs-Kornek&author=D%20Malhotra&author=AL%20Fletcher&volume=12&issue=11&publication_year=2011&pages=1096-1104&pmid=21926986&doi=10.1038/ni.2112&)] · DOI
  43. [44]Roberts DJ, Franklin NA, Kingeter LM, et al. Control of established melanoma by CD27 stimulation is associated with enhanced effector function and persistence, and reduced PD-1 expression of tumor infiltrating CD8(+) T cells. J Immunother. 2010;33(8):769–779. doi: 10.1097/CJI.0b013e3181ee238f. [[DOI](https://doi.org/10.1097/CJI.0b013e3181ee238f)] [[PMC free article](/articles/PMC2955154/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/20842060/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Immunother&title=Control%20of%20established%20melanoma%20by%20CD27%20stimulation%20is%20associated%20with%20enhanced%20effector%20function%20and%20persistence,%20and%20reduced%20PD-1%20expression%20of%20tumor%20infiltrating%20CD8(+)%20T%20cells.&author=DJ%20Roberts&author=NA%20Franklin&author=LM%20Kingeter&volume=33&issue=8&publication_year=2010&pages=769-779&pmid=20842060&doi=10.1097/CJI.0b013e3181ee238f&)] · DOI
  44. [45]Petschner F, Zimmerman C, Strasser A, Grillot D, Nunez G, Pircher H. Constitutive expression of Bcl-xL or Bcl-2 prevents peptide antigen-induced T cell deletion but does not influence T cell homeostasis after a viral infection. Eur J Immunol. 1998;28(2):560–569. doi: 10.1002/(SICI)1521-4141(199802)28:02<560::AID-IMMU560>3.0.CO;2-Q. [[DOI](https://doi.org/10.1002/(SICI)1521-4141(199802)28:02<560::AID-IMMU560>3.0.CO;2-Q)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/9521066/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Eur%20J%20Immunol&title=Constitutive%20expression%20of%20Bcl-xL%20or%20Bcl-2%20prevents%20peptide%20antigen-induced%20T%20cell%20deletion%20but%20does%20not%20influence%20T%20cell%20homeostasis%20after%20a%20viral%20infection.&author=F%20Petschner&author=C%20Zimmerman&author=A%20Strasser&author=D%20Grillot&author=G%20Nunez&volume=28&issue=2&publication_year=1998&pages=560-569&pmid=9521066&doi=10.1002/(SICI)1521-4141(199802)28:02<560::AID-IMMU560>3.0.CO;2-Q&)] · DOI
  45. [46]Davey GM, Kurts C, Miller JF, et al. Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim. J Exp Med. 2002;196(7):947–955. doi: 10.1084/jem.20020827. [[DOI](https://doi.org/10.1084/jem.20020827)] [[PMC free article](/articles/PMC2194028/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/12370256/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Exp%20Med&title=Peripheral%20deletion%20of%20autoreactive%20CD8%20T%20cells%20by%20cross%20presentation%20of%20self-antigen%20occurs%20by%20a%20Bcl-2-inhibitable%20pathway%20mediated%20by%20Bim.&author=GM%20Davey&author=C%20Kurts&author=JF%20Miller&volume=196&issue=7&publication_year=2002&pages=947-955&pmid=12370256&doi=10.1084/jem.20020827&)] · DOI
  46. [47]Hernandez J, Aung S, Redmond WL, Sherman LA. Phenotypic and functional analysis of CD8+ T cells undergoing peripheral deletion in response to cross-presentation of self-antigen. J Exp Med. 2001;194(6):707–718. doi: 10.1084/jem.194.6.707. [[DOI](https://doi.org/10.1084/jem.194.6.707)] [[PMC free article](/articles/PMC2195957/)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/11560988/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Exp%20Med&title=Phenotypic%20and%20functional%20analysis%20of%20CD8+%20T%20cells%20undergoing%20peripheral%20deletion%20in%20response%20to%20cross-presentation%20of%20self-antigen.&author=J%20Hernandez&author=S%20Aung&author=WL%20Redmond&author=LA%20Sherman&volume=194&issue=6&publication_year=2001&pages=707-718&pmid=11560988&doi=10.1084/jem.194.6.707&)] · DOI
  47. [48]Redmond WL, Marincek BC, Sherman LA. Distinct requirements for deletion versus anergy during CD8 T cell peripheral tolerance in vivo. J Immunol. 2005;174(4):2046–2053. doi: 10.4049/jimmunol.174.4.2046. [[DOI](https://doi.org/10.4049/jimmunol.174.4.2046)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/15699134/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Immunol&title=Distinct%20requirements%20for%20deletion%20versus%20anergy%20during%20CD8%20T%20cell%20peripheral%20tolerance%20in%20vivo.&author=WL%20Redmond&author=BC%20Marincek&author=LA%20Sherman&volume=174&issue=4&publication_year=2005&pages=2046-2053&pmid=15699134&doi=10.4049/jimmunol.174.4.2046&)] · DOI
  48. [49]Fife BT, Pauken KE. The role of the PD-1 pathway in autoimmunity and peripheral tolerance. Ann NY Acad Sci. 2011;1217:45–59. doi: 10.1111/j.1749-6632.2010.05919.x. [[DOI](https://doi.org/10.1111/j.1749-6632.2010.05919.x)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/21276005/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Ann%20NY%20Acad%20Sci&title=The%20role%20of%20the%20PD-1%20pathway%20in%20autoimmunity%20and%20peripheral%20tolerance.&author=BT%20Fife&author=KE%20Pauken&volume=1217&publication_year=2011&pages=45-59&pmid=21276005&doi=10.1111/j.1749-6632.2010.05919.x&)] · DOI
  49. [50]Welt S, Scott AM, Divgi CR, et al. Phase I/II study of iodine 125-labeled monoclonal antibody A33 in patients with advanced colon cancer. J Clin Oncol. 1996;14(6):1787–1797. doi: 10.1200/JCO.1996.14.6.1787. [[DOI](https://doi.org/10.1200/JCO.1996.14.6.1787)] [[PubMed](https://pubmed.ncbi.nlm.nih.gov/8656247/)] [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=J%20Clin%20Oncol&title=Phase%20I/II%20study%20of%20iodine%20125-labeled%20monoclonal%20antibody%20A33%20in%20patients%20with%20advanced%20colon%20cancer.&author=S%20Welt&author=AM%20Scott&author=CR%20Divgi&volume=14&issue=6&publication_year=1996&pages=1787-1797&pmid=8656247&doi=10.1200/JCO.1996.14.6.1787&)] · DOI

Cited by

Sorted by citations

Authors
Tewalt, E. F., Cohen, J. N., Rouhani, S. J., Guidi, C. J., Qiao, H., Fahl, S. P., Conaway, M. R., Bender, T. P., Tung, K. S., Vella, A. T., Adler, A. J., Chen, L., & Engelhard, V. H.
Affiliations
  • Department of Microbiology, Immunology, and Cancer Biology,
  • Carter Immunology Center,
  • University of Virginia (US)
  • UConn Health (US)
  • Yale University (US)
ORCID
Venue
Blood
Publisher
American Society of Hematology
Published
2012-12-06
Volume
120
Issue
24
Pages
4772-4782
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood-2012-04-427013
PMC
PMC3520619
OpenAlex
W2062196321
Cited by
270
References
1
Citations by year
2026: 7 · 2025: 18 · 2024: 12 · 2023: 22 · 2022: 26 · 2021: 29 · 2020: 22 · 2019: 26 · 2018: 15 · 2017: 20 · 2016: 22 · 2015: 21 · 2014: 19 · 2013: 7 · 2012: 3
FWCI
6.99
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Cancer Institute (CA-44579, R01CA109339, P30CA044579)
  • National Institute of General Medical Sciences (GM007267, R01GM100776, T32GM007267)
  • National Institute of Allergy and Infectious Diseases (AI07496, R01AI068836, AI068836, T32AI007496)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords
lymphatic endothelial cells, peripheral tolerance, PD-L1, PD-1, CD8+ T cells, costimulation, 4-1BB, CD160, BTLA, LAG-3, interleukin-2 receptor, T cell deletion, autoimmune vitiligo, antigen presentation, inhibitory receptors
MeSH terms
Animals, Antigen-Presenting Cells, Autoimmune Diseases, Immune Tolerance, Lymph Nodes, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Fluorescence, Receptors, Antigen, T-Cell, Monophenol Monooxygenase, Vitiligo, Signal Transduction, Mice, Knockout, CD8-Positive T-Lymphocytes, Adoptive Transfer, Lymphatic Vessels, Endothelial Cells, Mice, Tumor Necrosis Factor Receptor Superfamily, Member 9, Receptors, OX40, B7-H1 Antigen, Programmed Cell Death 1 Receptor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review