Shaping of Peripheral T Cell Responses by Lymphatic Endothelial Cells
Open accessAbstract
Lymph node stromal cells (LNSCs) have newly been promoted to the rank of new modulators of T cell responses. The different non-hematopoietic cell subsets in LN were considered for years as a simple scaffold, forming routes and proper environment for antigen-lymphocyte encountering. Though, deeper characterization of those cells has recently clearly shown their impact on both DC and T cell functions. In particular, lymphatic endothelial cells (LECs) control lymphocyte trafficking and homeostasis in lymph nodes (LNs), and limit adaptive immune responses. Therefore, the new role of LECs in shaping immune responses has drawn the attention of immunologists. Striking is the discovery that LECs, among other LNSCs, ectopically express a large range of peripheral tissue antigens (PTAs), and further present PTA-derived peptides through MHC class I (MHC-I) molecules to induce self-reactive CD8+ T cell deletional tolerance. In addition, both steady-state and tumor-associated LECs were described to be capable of exogenous antigen cross-presentation. Whether LECs can similarly impact CD4+ T cell responses through MHC class II (MHC-II) restricted Ag presentation is still a matter of debate. Here we review and discuss our current knowledge on the contribution of Ag-presenting LECs as regulators of peripheral T cell responses in different immunological contexts, including autoimmunity and cancer.
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Structural cells (epithelium, endothelium, and fibroblasts) have been shown to contribute in important ways to mammalian immunity.
“These three cell types, which we refer to as “structural cells”, have been shown to contribute in important ways to mammalian immunity7–11.”
From Structural cells are key regulators of organ-specific immune responses (2020) · cites this paper as [7]
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1 Lymphatic System Lymphatic system
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- Authors
- Humbert, M., Hugues, S., & Dubrot, J.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Hugues, Stéphanie
- Dubrot, Juan
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2017-01-12
- Volume
- 7
- Pages
- 684-684
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC5226940
- OpenAlex
- W2576305170
- Cited by
- 32
- References
- 131
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 9 · 2019: 5 · 2018: 1 · 2017: 1
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (310030_166541)
- European Research Council (281365)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Keywords
- lymphatic endothelial cells, lymph node stromal cells, lymphocyte migration, MHC class I antigen presentation, MHC class II antigen presentation, autoimmunity, CD4+ T cell responses
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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