The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma
Open accessAbstract
Carfilzomib is a next-generation, selective proteasome inhibitor being evaluated for the treatment of relapsed and refractory multiple myeloma. In this open-label, single-arm phase 2 study (PX-171-003-A1), patients received single-agent carfilzomib 20 mg/m2 intravenously twice weekly for 3 of 4 weeks in cycle 1, then 27 mg/m2 for ≤ 12 cycles. The primary endpoint was overall response rate (≥ partial response). Secondary endpoints included clinical benefit response rate (≥ minimal response), duration of response, progression-free survival, overall survival, and safety. A total of 266 patients were evaluable for safety, 257 for efficacy; 95% were refractory to their last therapy; 80% were refractory or intolerant to both bortezomib and lenalidomide. Patients had median of 5 prior lines of therapy, including bortezomib, lenalidomide, and thalidomide. Overall response rate was 23.7% with median duration of response of 7.8 months. Median overall survival was 15.6 months. Adverse events (AEs) were manageable without cumulative toxicities. Common AEs were fatigue (49%), anemia (46%), nausea (45%), and thrombocytopenia (39%). Thirty-three patients (12.4%) experienced peripheral neuropathy, primarily grades 1 or 2. Thirty-three patients (12.4%) withdrew because of an AE. Durable responses and an acceptable tolerability profile in this heavily pretreated population demonstrate the potential of carfilzomib to offer meaningful clinical benefit. This trial was registered at www.clinicaltrials.gov as #NCT00511238.
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A Phase 2 Study of Bortezomib in Relapsed, Refractory Myeloma
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Carfilzomib, Lenalidomide, and Dexamethasone for Relapsed Multiple Myeloma
Stewart, A. K., Rajkumar, S. V., Dimopoulos, M. A., Masszi, T., Špička, I., Oriol, A., Hájek, R., Rosiñol, L., Siegel, D. S., Mihaylov, G. G., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1411321 · Cited by 1,332
Self-citationTargeting CD38 with Daratumumab Monotherapy in Multiple Myeloma
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Proteasome inhibitors in cancer therapy
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Self-citationMultiple Myeloma: Diagnosis and Treatment
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Metadata
- Authors
- Siegel, D. S., Martin, T., Wang, M., Vij, R., Jakubowiak, A. J., Lonial, S., Trudel, S., Kukreti, V., Bahlis, N., Alsina, M., Chanan-Khan, A., Buadi, F., Reu, F. J., Somlo, G., Zonder, J., Song, K., Stewart, A. K., Stadtmauer, E., Kunkel, L., Wear, S., Wong, A. F., Orlowski, R. Z., & Jagannath, S.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2012-10-04
- Volume
- 120
- Issue
- 14
- Pages
- 2817-2825
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2089311432
- Cited by
- 657
- References
- 46
- FWCI
- 51.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma. https://app.cochat.ai/papers/10.1182/blood-2012-05-425934
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- Siegel, D. S., Martin, T., Wang, M., Vij, R., Jakubowiak, A. J., Lonial, S., Trudel, S., Kukreti, V., Bahlis, N., Alsina, M., Chanan-Khan, A., Buadi, F., Reu, F. J., Somlo, G., Zonder, J., Song, K., Stewart, A. K., Stadtmauer, E., Kunkel, L., . . . Jagannath, S. (2012). A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma. Blood. https://doi.org/10.1182/blood-2012-05-425934
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
