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The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions
Open accessAbstract
Although earlier, seminal studies demonstrated that the gut per se has the intrinsic ability to regulate the rates of iron absorption, the spotlight in the past decade has been placed on the systemic regulation of iron homeostasis by the hepatic hormone hepcidin and the molecular mechanisms that regulate its expression. Recently, however, attention has returned to the gut based on the finding that hypoxia inducible factor-2 (HIF-2α) regulates the expression of key genes that contribute to iron absorption. Here we review the current understanding of the molecular mechanisms that regulate iron homeostasis in the gut by focusing on the role of HIF-2 under physiological steady-state conditions and in the pathogenesis of iron-related diseases. We also discuss implications for adapting HIF-2–based therapeutic strategies in iron-related pathological conditions.
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“In the hypoxic duodenal environment, IRP1 controls translation of hypoxia-inducible factor 2α (HIF-2α) which, stabilized by prolyl hydroxylase, upregulates the expression of apical (DMT1) and basolateral (ferroportin) enterocyte iron transporters.62”
From Iron metabolism and iron disorders revisited in the hepcidin era (2020) · cites this paper as [62]
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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
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Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
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Two to tango: Regulation of Mammalian iron metabolism
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Camaschella, C. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1401038 · Cited by 1,678
Iron metabolism and iron disorders revisited in the hepcidin era
Camaschella, C., Nai, A., & Silvestri, L. (2020) · Haematologica · doi:10.3324/haematol.2019.232124 · Cited by 734
“In the hypoxic duodenal environment, IRP1 controls translation of hypoxia-inducible factor 2α (HIF-2α) which, stabilized by prolyl hydroxylase, upregulates the expression of apical (DMT1) and basolateral (ferroportin) enterocyte iron transporters.(62) In iron deficiency, absorption is enhanced by hepcidin downregulati…”
Camaschella, C. (2019) · Blood · doi:10.1182/blood-2018-05-815944 · Cited by 702
Moretti, D., Goede, J. S., Zeder, C., Jiskra, M., Chatzinakou, V., Tjalsma, H., Melse-Boonstra, A., Brittenham, G., Swinkels, D. W., & Zimmermann, M. B. (2015) · Blood · doi:10.1182/blood-2015-05-642223 · Cited by 547
Iron deficiency anaemia revisited
Cappellini, M. D., Musallam, K. M., & Taher, A. T. (2019) · Journal of Internal Medicine · doi:10.1111/joim.13004 · Cited by 591
Metadata
- Authors
- Mastrogiannaki, M., Matak, P., & Peyssonnaux, C.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- ORCID
- Peyssonnaux, Carole
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2013-08-08
- Volume
- 122
- Issue
- 6
- Pages
- 885-892
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC3743464
- OpenAlex
- W2160602863
- Cited by
- 116
- References
- 102
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 8 · 2020: 10 · 2019: 4 · 2018: 13 · 2017: 7 · 2016: 8 · 2015: 17 · 2014: 6 · 2013: 4
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Physical Sciences › Materials Science › Metals and Alloys › Iron and Steelmaking Processes
- Keywords
- iron homeostasis, HIF-2α, HIF-2, hepcidin, iron-related diseases
- MeSH terms
- Endothelial PAS Domain-Containing Protein 1, Animals, Hypoxia, Gene Expression Regulation, Hemochromatosis, Homeostasis, Humans, Inflammation, Iron, Male, Polycythemia, Enterocytes, Hepatocytes, Antimicrobial Cationic Peptides, Iron Regulatory Protein 1, Iron Regulatory Protein 2, Gastrointestinal Tract, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Hepcidins
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