Cited by 116Iron Metabolism and DisordersErythropoietin and Anemia TreatmentIron and Steelmaking Processes

The DOI matches its Crossref record; 100 of the 102 references it cites were found in a registry or an index.

The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions

Open access

Mastrogiannaki, Maria, Matak, Pavle, Peyssonnaux, Carole·2013·Blood

DOI 10.1182/blood-2012-11-427765PMC PMC3743464

Open this paper in CoChat — free account Open PDF

Abstract

Although earlier, seminal studies demonstrated that the gut per se has the intrinsic ability to regulate the rates of iron absorption, the spotlight in the past decade has been placed on the systemic regulation of iron homeostasis by the hepatic hormone hepcidin and the molecular mechanisms that regulate its expression. Recently, however, attention has returned to the gut based on the finding that hypoxia inducible factor-2 (HIF-2α) regulates the expression of key genes that contribute to iron absorption. Here we review the current understanding of the molecular mechanisms that regulate iron homeostasis in the gut by focusing on the role of HIF-2 under physiological steady-state conditions and in the pathogenesis of iron-related diseases. We also discuss implications for adapting HIF-2–based therapeutic strategies in iron-related pathological conditions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1182/blood-2012-11-427765

Cites

100 of 100 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.
Kaelin, W. G., & Ratcliffe, P. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.009 · Cited by 3,251
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650
Two to tango: Regulation of Mammalian iron metabolism
Hentze, M. W., Muckenthaler, M. U., Galy, B., & Camaschella, C. (2010) · Cell · doi:10.1016/j.cell.2010.06.028 · Cited by 2,120
A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation
McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80425-6 · Cited by 1,422
FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
Mahon, P. C., Hirota, K., & Semenza, G. L. (2001) · Genes & Development · doi:10.1101/gad.924501 · Cited by 1,385
Hepcidin and iron homeostasis
Ganz, T., & Nemeth, E. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.01.014 · Cited by 1,282
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
Donovan, A., Lima, C. A., Pinkus, J. L., Pinkus, G. S., Zon, L. I., Robine, S., & Andrews, N. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.003 · Cited by 1,275
Genetic Evidence for High-Altitude Adaptation in Tibet
Simonson, T. S., Yang, Y., Huff, C. D., Yun, H., Qin, G., Witherspoon, D. J., Bai, Z., Lorenzo, F. R., Xing, J., Jorde, L. B., et al. (2010) · Science · doi:10.1126/science.1189406 · Cited by 1,227
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., & Vaulont, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215686 · Cited by 1,214
An iron-regulated ferric reductase associated with the absorption of dietary iron
McKie, A. T., Barrow, D., Latunde-Dada, G. O., Rolfs, A., Sager, G., Mudaly, E., Mudaly, M., Richardson, C., Barlow, D., Bomford, A., et al. (2001) · Science · doi:10.1126/science.1057206 · Cited by 1,101
Integration of Oxygen Signaling at the Consensus HRE
Wenger, R. H., Stiehl, D. P., & Camenisch, G. (2005) · Science's STKE · doi:10.1126/stke.3062005re12 · Cited by 1,032
High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
Tanno, T., Bhanu, N. V., Oneal, P. A., Goh, S.-H., Staker, P., Lee, Y. T., Moroney, J. W., Reed, C. H., Luban, N. L., Wang, R.-H., et al. (2007) · Nature Medicine · doi:10.1038/nm1629 · Cited by 854
Identification of an Intestinal Folate Transporter and the Molecular Basis for Hereditary Folate Malabsorption
Qiu, A., Jansen, M., Sakaris, A., Min, S. H., Chattopadhyay, S., Tsai, E., Sandoval, C., Zhao, R., Akabas, M. H., & Goldman, I. D. (2006) · Cell · doi:10.1016/j.cell.2006.09.041 · Cited by 847
Natural selection on EPAS1 ( HIF2α ) associated with low hemoglobin concentration in Tibetan highlanders
Beall, C. M., Cavalleri, G. L., Deng, L., Elston, R. C., Gao, Y., Knight, J., Li, C., Li, J. C., Liang, Y., McCormack, M., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002443107 · Cited by 845
Widespread, hypoxia‐inducible expression of HIF‐2α in distinct cell populations of different organs
Wiesener, M. S., Jürgensen, J. S., Rosenberger, C., Scholze, C. K., Hörstrup, J. H., Warnecke, C., Mandriota, S. J., Bechmann, I., Frei, U. A., Pugh, C. W., et al. (2002) · The FASEB Journal · doi:10.1096/fj.02-0445fje · Cited by 770
Forging a field: the golden age of iron biology.
Andrews, N. C. (2008) · Blood · doi:10.1182/blood-2007-12-077388 · Cited by 623
HIF-2α, but not HIF-1α, promotes iron absorption in mice
Mastrogiannaki, M., Matak, P., Keith, B., Simon, M. C., Vaulont, S., & Peyssonnaux, C. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38499 · Cited by 502
Self-citation
Mammalian iron metabolism and its control by iron regulatory proteins
Anderson, C. P., Shen, M., Eisenstein, R. S., & Leibold, E. A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.05.010 · Cited by 493
Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency
Shah, Y. M., Matsubara, T., Ito, S., Yim, S.-H., & Gonzalez, F. J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.012 · Cited by 431
Control of iron homeostasis by an iron-regulated ubiquitin ligase
Vashisht, A. A., Zumbrennen, K. B., Huang, X., Powers, D. N., Durazo, A., Sun, D., Bhaskaran, N., Persson, A., Uhlen, M., Sangfelt, O., et al. (2009) · Science · doi:10.1126/science.1176333 · Cited by 429
Identification of a Human Heme Exporter that Is Essential for Erythropoiesis
Quigley, J. G., Yang, Z., Worthington, M., Phillips, J. D., Sabo, K. M., Sabath, D. E., Berg, C. L., Sassa, S., Wood, B. L., & Abkowitz, J. L. (2004) · Cell · doi:10.1016/j.cell.2004.08.014 · Cited by 423
Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver
Gunshin, H., Fujiwara, Y., Custodio, A. O., DiRenzo, C., Robine, S., & Andrews, N. C. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24356 · Cited by 419
pH control mechanisms of tumor survival and growth
Parks, S. K., Chiche, J., & Pouysségur, J. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22400 · Cited by 356
The N-Terminal Transactivation Domain Confers Target Gene Specificity of Hypoxia-inducible Factors HIF-1α and HIF-2α
Hu, C.-J., Sataur, A., Wang, L., Chen, H., & Simon, M. C. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-05-0419 · Cited by 355
Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats
Frazer, D. M., Wilkins, S. J., Becker, E., Vulpe, C. D., McKie, A. T., Trinder, D., & Anderson, G. J. (2002) · Gastroenterology · doi:10.1053/gast.2002.35353 · Cited by 345
Hypoxia-inducible factor 2 regulates hepatic lipid metabolism
Rankin, E. B., Rha, J., Selak, M. A., Unger, T. L., Keith, B., Liu, Q., & Haase, V. H. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00200-09 · Cited by 338
Iron metabolism in the anemia of chronic disease
Weiss, G. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.08.006 · Cited by 322
Ineffective erythropoiesis in β-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin
Gardenghi, S., Marongiu, M. F., Ramos, P., Guy, E. C., Breda, L., Chadburn, A., Liu, Y.-F., Amariglio, N., Rechavi, G., Rachmilewitz, E. A., et al. (2007) · Blood · doi:10.1182/blood-2006-09-048868 · Cited by 314
Hypoxia and gastrointestinal disease
Taylor, C. T., & Colgan, S. P. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0277-z · Cited by 313
Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs
Rivera, S., Nemeth, E., Gabayan, V., Lopez, M. A., Farshidi, D., & Ganz, T. (2005) · Blood · doi:10.1182/blood-2005-04-1766 · Cited by 308
Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia
Kapitsinou, P. P., Liu, Q., Unger, T. L., Rha, J., Davidoff, O., Keith, B., Epstein, J. A., Moores, S. L., Erickson-Miller, C. L., & Haase, V. H. (2010) · Blood · doi:10.1182/blood-2010-02-270322 · Cited by 307
The Oxygen Sensor Factor-Inhibiting Hypoxia-Inducible Factor-1 Controls Expression of Distinct Genes through the Bifunctional Transcriptional Character of Hypoxia-Inducible Factor-1α
Dayan, F., Roux, D., Brahimi-Horn, M. C., Pouyssegur, J., & Mazure, N. M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4564 · Cited by 294
Iron-regulatory proteins limit hypoxia-inducible factor-2α expression in iron deficiency
Sanchez, M., Galy, B., Muckenthaler, M. U., & Hentze, M. W. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1222 · Cited by 294
A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression
Zhang, D.-L., Hughes, R. M., Ollivierre-Wilson, H., Ghosh, M. C., & Rouault, T. A. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.03.006 · Cited by 281
P HYSIOLOGY AND M OLECULAR B IOLOGY OF D IETARY I RON A BSORPTION
Miret, S., Simpson, R. J., & McKie, A. T. (2003) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.23.011702.073139 · Cited by 274
Hypoxia-Inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice
Taylor, M., Qu, A., Anderson, E. R., Matsubara, T., Martin, A., Gonzalez, F. J., & Shah, Y. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.03.007 · Cited by 265
Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis
Lesbordes-Brion, J.-C., Viatte, L., Bennoun, M., Lou, D.-Q., Ramey, G., Houbron, C., Hamard, G., Kahn, A., & Vaulont, S. (2006) · Blood · doi:10.1182/blood-2006-02-003376 · Cited by 257
HRG1 Is Essential for Heme Transport from the Phagolysosome of Macrophages during Erythrophagocytosis
White, C., Yuan, X., Schmidt, P. J., Bresciani, E., Samuel, T. K., Campagna, D. R., Hall, C., Bishop, K. S., Calicchio, M. L., Lapierre, A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.005 · Cited by 257
The molecular basis of ferroportin-linked hemochromatosis
De Domenico, I., Ward, D. M., Nemeth, E., Vaughn, M. B., Musci, G., Ganz, T., & Kaplan, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503804102 · Cited by 230
Intestinal DMT1 cotransporter is down-regulated by hepcidin via proteasome internalization and degradation
Brasse–Lagnel, C., Karim, Z., Letteron, P., Bekri, S., Bado, A., & Beaumont, C. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.12.037 · Cited by 230
Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)
Galy, B., Ferring–Appel, D., Miñana, B., Bell, O., Janser, H., Muckenthaler, M. U., Schümann, K., & Hentze, M. W. (2005) · Blood · doi:10.1182/blood-2005-04-1365 · Cited by 224
Pathways of Iron Absorption
Conrad, M. E., & Umbreit, J. N. (2002) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2002.0564 · Cited by 219
Role of the hypoxia inducible factors HIF in iron metabolism
Peyssonnaux, C., Nizet, V., & Johnson, R. S. (2008) · Cell Cycle · doi:10.4161/cc.7.1.5145 · Cited by 217
Self-citation
Genes that modify the hemochromatosis phenotype in mice
Levy, J. E., Montross, L. K., & Andrews, N. C. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9635 · Cited by 212
The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption
Anderson, S. A., Nizzi, C. P., Chang, Y.-I., Deck, K. M., Schmidt, P. J., Galy, B., Damnernsawad, A., Broman, A. T., Kendziorski, C., Hentze, M. W., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.007 · Cited by 211
β-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism
Ginzburg, Y., & Rivella, S. (2011) · Blood · doi:10.1182/blood-2011-03-283614 · Cited by 201
Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia
Rivera, S., Liu, L., Nemeth, E., Gabayan, V., Sorensen, O. E., & Ganz, T. (2005) · Blood · doi:10.1182/blood-2004-08-3375 · Cited by 196
Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum
Galy, B., Ferring-Appel, D., Kaden, S., Gröne, H.-J., & Hentze, M. W. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.006 · Cited by 195
Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing
Zimmer, M., Ebert, B. L., Neil, C., Brenner, K., Papaioannou, I., Melas, A., Tolliday, N., Lamb, J., Pantopoulos, K., Golub, T., et al. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.12.004 · Cited by 191
A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption
Frazer, D. M. (2003) · Gut · doi:10.1136/gut.52.3.340 · Cited by 189
Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice
Gunshin, H., Starr, C. N., DiRenzo, C., Fleming, M. D., Jin, J., Greer, E. L., Sellers, V. M., Galica, S. M., & Andrews, N. C. (2005) · Blood · doi:10.1182/blood-2005-02-0716 · Cited by 188
Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α
Ghosh, M. C., Zhang, D.-L., Jeong, S. Y., Kovtunovych, G., Ollivierre-Wilson, H., Noguchi, A., Tu, T., Senecal, T., Robinson, G., Crooks, D. R., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.016 · Cited by 183
Hepcidin inhibits apical iron uptake in intestinal cells
Mena, N. P., Esparza, A., Tapia, V., Valdés, P., & Núñez, M. T. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00122.2007 · Cited by 180
Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation
Roy, C. N., Mak, H. H., Akpan, I., Losyev, G., Zurakowski, D., & Andrews, N. C. (2007) · Blood · doi:10.1182/blood-2006-10-051755 · Cited by 178
The Polycythemia of High Altitudes: Iron Metabolism and Related Aspects
REYNAFARJE, C., Lozano, R., & Valdivieso, J. (1959) · Blood · doi:10.1182/blood.v14.4.433.433 · Cited by 172
Steap Proteins: Implications for Iron and Copper Metabolism
Knutson, M. D. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00311.x · Cited by 165
Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project
Piperno, A., Galimberti, S., Mariani, R., Pelucchi, S., Ravasi, G., Lombardi, C., Bilo, G., Revera, M., Giuliano, A., Faini, A., et al. (2011) · Blood · doi:10.1182/blood-2010-08-299859 · Cited by 151
Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells
Chaston, T., Chung, B., Mascarenhas, M., Marks, J., Patel, B., Srai, S. K., & Sharp, P. (2008) · Gut · doi:10.1136/gut.2007.131722 · Cited by 145
Microcytic anemia and hepatic iron overload in a child with compound heterozygous mutations in DMT1 (SCL11A2)
Iolascon, A., D’Apolito, M., Servedio, V., Cimmino, F., Piga, A. G., & Camaschella, C. (2005) · Blood · doi:10.1182/blood-2005-06-2477 · Cited by 143
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2
Foot, N. J., Dalton, H. E., Shearwin-Whyatt, L. M., Dorstyn, L., Tan, S.-S., Yang, B., & Kumar, S. (2008) · Blood · doi:10.1182/blood-2008-04-150953 · Cited by 143
Intestinal Ferritin H Is Required for an Accurate Control of Iron Absorption
Vanoaica, L., Darshan, D., Richman, L., Schümann, K., & Kühn, L. C. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.08.003 · Cited by 137
Deregulation of proteins involved in iron metabolism in hepcidin-deficient mice
Viatte, L., Lesbordes, J.-C., Lou, D.-Q., Bennoun, M., Nicolas, G., Kahn, A., Canonne‐Hergaux, F., & Vaulont, S. (2005) · Blood · doi:10.1182/blood-2004-12-4608 · Cited by 119
Tumour necrosis factor α causes hypoferraemia and reduced intestinal iron absorption in mice
Laftah, A. H., Sharma, N., Brookes, M., McKie, A. T., Simpson, R. J., Iqbal, T. H., & Tselepis, C. (2006) · Biochemical Journal · doi:10.1042/bj20060215 · Cited by 114
Effect of Altitude on Erythropoiesis
Faura, J., RAMOS, J., REYNAFARJE, C., English, E., Finne, P. H., & Finch, C. A. (1969) · Blood · doi:10.1182/blood.v33.5.668.668 · Cited by 114
Decreased Hephaestin Activity in the Intestine of Copper-Deficient Mice Causes Systemic Iron Deficiency
Chen, H., Huang, G., Su, T., Gao, H., Attieh, Z. K., McKie, A. T., Anderson, G. J., & Vulpe, C. D. (2006) · Journal of Nutrition · doi:10.1093/jn/136.5.1236 · Cited by 109
Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1
Zoller, H., Theurl, I., Koch, R., Kaser, A., & Weiss, G. (2002) · Blood Cells, Molecules, and Diseases · doi:10.1006/bcmd.2002.0587 · Cited by 106
Iron regulatory proteins control a mucosal block to intestinal iron absorption
Galy, B., Ferring-Appel, D., Becker, C., Gretz, N., Gröne, H.-J., Schümann, K., & Hentze, M. W. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.02.026 · Cited by 98
Intestinal Iron Absorption: Regulation by Dietary & Systemic Factors
Sharp, P. (2010) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000029 · Cited by 95
Regulation of hepcidin expression at high altitude
Talbot, N. P., Lakhal, S., Smith, T. G., Privat, C., Nickol, A. H., Rivera-Ch, M., León-Velarde, F., Dorrington, K. L., Mole, D. R., & Robbins, P. A. (2012) · Blood · doi:10.1182/blood-2011-03-341776 · Cited by 93
The Molecular Pathogenesis of Hereditary Hemochromatosis
Babitt, J. L., & Lin, H. Y.-F. (2011) · Seminars in Liver Disease · doi:10.1055/s-0031-1286059 · Cited by 89
Regulation of systemic iron homeostasis: how the body responds to changes in iron demand
Anderson, G. J., Darshan, D., Wilkins, S. J., & Frazer, D. M. (2007) · BioMetals · doi:10.1007/s10534-006-9030-2 · Cited by 87
Heme and non-heme iron transporters in non-polarized and polarized cells
Yanatori, I., Tabuchi, M., Kawai, Y., Yasui, Y., Akagi, R., & Kishi, F. (2010) · BMC Cell Biology · doi:10.1186/1471-2121-11-39 · Cited by 86
Iron feeding induces ferroportin 1 and hephaestin migration and interaction in rat duodenal epithelium
Yeh, K., YEH, M. K. Y., Mims, L., & Glass, J. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90298.2008 · Cited by 85
In vivo studies on the relationship between intestinal iron (Fe3+) absorption, hypoxia and erythropoiesis in the mouse
Raja, K. B., Simpson, R. J., Pippard, M. J., & Peters, T. J. (1988) · British Journal of Haematology · doi:10.1111/j.1365-2141.1988.tb04217.x · Cited by 72
1,3,8-Triazaspiro[4.5]decane-2,4-diones as Efficacious Pan-Inhibitors of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia
Váchal, P., Miao, S., Pierce, J. M., Guiadeen, D., Colandrea, V. J., Wyvratt, M. J., Salowe, S. P., Sonatore, L. M., Milligan, J. A., Hajdu, R., et al. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm201542d · Cited by 67
Increased duodenal iron uptake and transfer in a rat model of chronic hypoxia is accompanied by reduced hepcidin expression
Leung, P. S. (2005) · Gut · doi:10.1136/gut.2004.062083 · Cited by 64
Iron Regulatory Protein 1 Outcompetes Iron Regulatory Protein 2 in Regulating Cellular Iron Homeostasis in Response to Nitric Oxide
Styś, A., Galy, B., Starzyński, R. R., Smuda, E., Drapier, J., Lipiński, P., & Bouton, C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.231902 · Cited by 64
A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis
Constantine, C. C., Anderson, G. J., Vulpe, C. D., McLaren, C. E., Bahlo, M., Yeap, H. L., Gertig, D. M., Osborne, N. J., Bertalli, N. A., Beckman, K. B., et al. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07843.x · Cited by 64
Self-citation
Copper Deficiency Leads to Anemia, Duodenal Hypoxia, Upregulation of HIF-2α and Altered Expression of Iron Absorption Genes in Mice
Matak, P., Zumerle, S., Mastrogiannaki, M., Balkhi, S. E., Delga, S., Mathieu, J. R. R., Canonne‐Hergaux, F., Poupon, J., Sharp, P., Vaulont, S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059538 · Cited by 62
Self-citation
Tumour necrosis factor alpha regulates iron transport and transporter expression in human intestinal epithelial cells
Johnson, D., Bayele, H. K., Johnston, K. L., Tennant, J. P., Srai, S. K., & Sharp, P. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.081 · Cited by 60
Duodenal Reductase Activity and Spleen Iron Stores Are Reduced and Erythropoiesis Is Abnormal in Dcytb Knockout Mice Exposed to Hypoxic Conditions3
Choi, J., Masaratana, P., Latunde-Dada, G. O., Arno, M. J., Simpson, R. J., & McKie, A. T. (2012) · Journal of Nutrition · doi:10.3945/jn.112.160358 · Cited by 60
Intestinal Hypoxia-inducible Factor-2α (HIF-2α) Is Critical for Efficient Erythropoiesis
Anderson, E. R., Xue, X., & Shah, Y. M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.238667 · Cited by 58
Deletion of HIF-2α in the enterocytes decreases the severity of tissue iron loading in hepcidin knockout mice
Mastrogiannaki, M., Matak, P., Delga, S., Deschemin, J.-C., Vaulont, S., & Peyssonnaux, C. (2012) · Blood · doi:10.1182/blood-2011-09-380337 · Cited by 57
Self-citation
Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism
Ferring–Appel, D., Hentze, M. W., & Galy, B. (2008) · Blood · doi:10.1182/blood-2008-05-155093 · Cited by 53
Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis
Latunde-Dada, G. O., Vulpe, C. D., Anderson, G. J., Simpson, R. J., & McKie, A. T. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.06.011 · Cited by 50
Animal Models of Anemia of Inflammation
Rivera, S., & Ganz, T. (2009) · Seminars in Hematology · doi:10.1053/j.seminhematol.2009.06.003 · Cited by 49
Not all DMT1 mutations lead to iron overload
Blanco, E., Kannengiesser, C., Grandchamp, B., Tasso, M., & Beaumont, C. (2009) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2009.05.003 · Cited by 48
Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure
Srai, S. K., Chung, B., Marks, J., Pourvali, K., Solanky, N., Rapisarda, C., Chaston, T. B., Hanif, R., Unwin, R. J., Debnam, E. S., et al. (2010) · Kidney International · doi:10.1038/ki.2010.217 · Cited by 44
Dietary Iron Levels and Hypoxia Independently affect Iron Absorption in Mice
Simpson, R. J. (1996) · Journal of Nutrition · doi:10.1093/jn/126.7.1858 · Cited by 37
Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency.
Recalcati, S., Alberghini, A., Campanella, A., Gianelli, U., Camilli, E. D., Conte, D., & Cairo, G. (2006) · PubMed · Cited by 34
The Influence of Hypoxia on Iron Absorption in the Rat
Hathorn, M. K. S. (1971) · Gastroenterology · doi:10.1016/s0016-5085(71)80009-4 · Cited by 32
Hypoxia Inducible Factor-2a Is Translationally Repressed in Response to Dietary Iron Deficiency in Sprague-Dawley Rats
Davis, M. R., Shawron, K., Rendina-Ruedy, E., Peterson, S., Lucas, E. A., Smith, B. J., & Clarke, S. L. (2011) · Journal of Nutrition · doi:10.3945/jn.111.144105 · Cited by 30
Effect of hypoxia on the expression of iron regulatory proteins 1 and the mechanisms involved
Luo, Q., Wang, D., Yu, M., & Zhu, L. (2011) · IUBMB Life · doi:10.1002/iub.419 · Cited by 22
Giving Anemia a Boost with Inhibitors of Prolyl Hydroxylase
Denny, W. A. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm300314a · Cited by 12
Hypoferraemia during the early inflammatory response is dependent on tumour necrosis factor activity in a murine model of protracted peritonitis
Schubert, T. E. O., Bosserhoff, A., Peyssonnaux, C., Echtenacher, B., Knutson, M. D., Hofstädter, F., & Männel, D. N. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2012.1004 · Cited by 7
Self-citation
Lack of iron-related phenotype in Sp6 intestinal knockout mice
Matak, P., Deschemin, J., Peyssonnaux, C., & Vaulont, S. (2011) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2011.03.009 · Cited by 3
Self-citation

Sorted by citations

Iron-Deficiency Anemia
Camaschella, C. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1401038 · Cited by 1,678
Iron metabolism and iron disorders revisited in the hepcidin era
Camaschella, C., Nai, A., & Silvestri, L. (2020) · Haematologica · doi:10.3324/haematol.2019.232124 · Cited by 734
“In the hypoxic duodenal environment, IRP1 controls translation of hypoxia-inducible factor 2α (HIF-2α) which, stabilized by prolyl hydroxylase, upregulates the expression of apical (DMT1) and basolateral (ferroportin) enterocyte iron transporters.(62) In iron deficiency, absorption is enhanced by hepcidin downregulati…”
Iron deficiency
Camaschella, C. (2019) · Blood · doi:10.1182/blood-2018-05-815944 · Cited by 702
Oral Iron Supplements Increase Hepcidin and Decrease Iron Absorption from Daily or Twice-Daily Doses in Iron-Depleted Young Women
Moretti, D., Goede, J. S., Zeder, C., Jiskra, M., Chatzinakou, V., Tjalsma, H., Melse-Boonstra, A., Brittenham, G., Swinkels, D. W., & Zimmermann, M. B. (2015) · Blood · doi:10.1182/blood-2015-05-642223 · Cited by 547
Iron deficiency anaemia revisited
Cappellini, M. D., Musallam, K. M., & Taher, A. T. (2019) · Journal of Internal Medicine · doi:10.1111/joim.13004 · Cited by 591

See all 116

Authors: Mastrogiannaki, M., Matak, P., & Peyssonnaux, C.
Affiliations: Centre National de la Recherche Scientifique (FR)
ORCID: Peyssonnaux, Carole
Venue: Blood
Publisher: American Society of Hematology
Published: 2013-08-08
Volume: 122
Issue: 6
Pages: 885-892
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2012-11-427765
PMC: PMC3743464
OpenAlex: W2160602863
Cited by: 116
References: 102
Citations by year: 2026: 8 · 2025: 9 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 8 · 2020: 10 · 2019: 4 · 2018: 13 · 2017: 7 · 2016: 8 · 2015: 17 · 2014: 6 · 2013: 4
FWCI: 1.78
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Physical Sciences › Materials Science › Metals and Alloys › Iron and Steelmaking Processes
Keywords: iron homeostasis, HIF-2α, HIF-2, hepcidin, iron-related diseases
MeSH terms: Endothelial PAS Domain-Containing Protein 1, Animals, Hypoxia, Gene Expression Regulation, Hemochromatosis, Homeostasis, Humans, Inflammation, Iron, Male, Polycythemia, Enterocytes, Hepatocytes, Antimicrobial Cationic Peptides, Iron Regulatory Protein 1, Iron Regulatory Protein 2, Gastrointestinal Tract, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Hepcidins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks