Cited by 100T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesHIV Research and Treatment

CD40L expression permits CD8+ T cells to execute immunologic helper functions

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Frentsch, Marco, Stark, Regina, Matzmohr, Nadine, Meier, Sarah, Durlanik, Sibel, Schulz, Axel R., Stervbo, Ulrik, Jürchott, Karsten +6 more·2013·Blood

Abstract

Key Points: A major part of CD8+ memory T cells expresses CD40L, the key molecule for T-cell–dependent help. CD40L-expressing CD8+ T cells resemble functional CD4+ helper T cells.

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Crossref · 10.1182/blood-2013-02-483586

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Authors
Frentsch, M., Stark, R., Matzmohr, N., Meier, S., Durlanik, S., Schulz, A. R., Stervbo, U., Jürchott, K., Gebhardt, F., Heine, G., Reuter, M. A., Betts, M. R., Busch, D., & Thiel, A.
Affiliations
  • Berlin-Brandenburger Centrum für Regenerative Therapien (DE)
  • Humboldt-Universität zu Berlin (DE)
  • Technical University of Munich (DE)
  • Charité – Universitätsmedizin Berlin (DE)
  • University of Pennsylvania (US)
Venue
Blood
Published
2013-07-18
Volume
122
Issue
3
Pages
405-412
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W2034804331
Cited by
100
References
41
Citations by year
2026: 4 · 2025: 8 · 2024: 7 · 2023: 9 · 2022: 4 · 2021: 9 · 2020: 13 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 12 · 2015: 9 · 2014: 9 · 2013: 3
FWCI
6.08
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Funders
National Institute of Allergy and Infectious Diseases (R01AI076066)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords
CD40 ligand, CD8+ T cells, T cell help, MHC class I-restricted T cells, antigen-presenting cell activation, cytokine expression, influenza virus, yellow fever virus, memory T cells, cytotoxic T lymphocytes, immunotherapy
MeSH terms
Animals, Epitopes, Cytotoxicity, Immunologic, T-Lymphocytes, Helper-Inducer, Humans, Immunologic Memory, Mice, Inbred C57BL, Immunophenotyping, Cytokines, CD8-Positive T-Lymphocytes, CD40 Ligand, Mice

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