CD40L expression permits CD8+ T cells to execute immunologic helper functions
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Key Points: A major part of CD8+ memory T cells expresses CD40L, the key molecule for T-cell–dependent help. CD40L-expressing CD8+ T cells resemble functional CD4+ helper T cells.
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A subset of CD8 T cells can mediate help via CD40L.
“and a subset of CD8 T cells can mediate help via CD40L [232].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [232]
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R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,706 · see citing works
Bioconductor: open software development for computational biology and bioinformatics
Gentleman, R., Carey, V., Bates, D., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome Biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 13,133 · see citing works
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · see citing works
T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
Schoenberger, S. P., Toes, R. E. M., van der Voort, E. I. H., Offringa, R., & Melief, C. J. M. (1998) · Nature · doi:10.1038/31002 · Cited by 2,615 · see citing works
Fitzgerald, M., Hayward, I. P., Thomas, A. C., Campbell, J. H., & CAMPBELL, G. R. (1995) · Cited by 2,552 · see citing works
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
Ridge, J. P., Rosa, F. D., & Matzinger, P. (1998) · Nature · doi:10.1038/30989 · Cited by 2,360 · see citing works
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
Bennett, S. R. M., Carbone, F., Karamalis, F., Flavell, R. A., Miller, J. F. A. P., & Heath, W. R. (1998) · Nature · doi:10.1038/30996 · Cited by 2,091 · see citing works
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
Betts, M. R. (2006) · Blood · doi:10.1182/blood-2005-12-4818 · Cited by 1,812 · see citing works
Self-citationCD4 T cells: fates, functions, and faults
Zhu, J., & Paul, W. E. (2008) · Blood · doi:10.1182/blood-2008-05-078154 · Cited by 1,796 · see citing works
CD40 AND CD154 IN CELL-MEDIATED IMMUNITY
Grewal, I. S., & Flavell, R. A. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.111 · Cited by 1,538 · see citing works
Immunological mechanisms of vaccination
Pulendran, B., & Ahmed, R. (2011) · Nature Immunology · doi:10.1038/ni.2039 · Cited by 1,085 · see citing works
Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily.
Zhou, L., & Tedder, T. F. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.8.3821 · Cited by 751 · see citing works
Phenotype and function of human T lymphocyte subsets: Consensus and issues
Appay, V., van Lier, R. A. W., Sallusto, F., & Roederer, M. (2008) · Cytometry Part A · doi:10.1002/cyto.a.20643 · Cited by 729 · see citing works
Characterization of CD4+ CTLs Ex Vivo
Appay, V., Zaunders, J. J., Papagno, L., Sutton, J., Jaramillo, A., Waters, A., Easterbrook, P., Grey, P., Smith, D. E., McMichael, A. J., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5954 · Cited by 545 · see citing works
Monath, T. P. C. (2001) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(01)00016-0 · Cited by 542 · see citing works
Direct access to CD4+ T cells specific for defined antigens according to CD154 expression
Frentsch, M., Arbach, O., Kirchhoff, D., Moewes, B., Worm, M., Rothe, M., Scheffold, A., & Thiel, A. (2005) · Nature Medicine · doi:10.1038/nm1292 · Cited by 475 · see citing works
Self-citationHuster, K. M., Busch, V., Schiemann, M., Linkemann, K., Kerksiek, K. M., Wagner, H., & Busch, D. H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308054101 · Cited by 474 · see citing works
Self-citationCross-priming in health and disease
Kurts, C., Robinson, B. W. S., & Knolle, P. A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2780 · Cited by 427 · see citing works
Davison, A. J., Dolan, A., Akter, P., Addison, C., Dargan, D. J., Alcendor, D. J., McGeoch, D. J., & Hayward, G. S. (2003) · Journal of General Virology · doi:10.1099/vir.0.18606-0 · Cited by 397 · see citing works
The Yellow Fever Virus Vaccine Induces a Broad and Polyfunctional Human Memory CD8+ T Cell Response
Akondy, R. S., Monson, N. D., Miller, J. D., Edupuganti, S., Teuwen, D. E., Wu, H. G., Quyyumi, F. F., Garg, S., Altman, J. D., del Rı́o, C., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803903 · Cited by 345 · see citing works
Human CD8+ T-cell differentiation in response to viruses
van Lier, R. A. W., ten Berge, I. J. M., & Gamadia, L. E. (2003) · Nature Reviews Immunology · doi:10.1038/nri1254 · Cited by 297 · see citing works
Complementary Dendritic Cell–activating Function of CD8+ and CD4+ T Cells
Mailliard, R. B., Egawa, S., Cai, Q., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011662 · Cited by 161 · see citing works
Chen, G., Shankar, P., Lange, C. G., Valdez, H., Skolnik, P. R., Wu, L., Manjunath, N., & Lieberman, J. (2001) · Blood · doi:10.1182/blood.v98.1.156 · Cited by 159 · see citing works
van Kooten, C., Gaillard, C., Galizzi, J., et al. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240402 · Cited by 154 · see citing works
Taraban, V. Y., Rowley, T. F., O'Brien, L., Chan, H. T. C., Haswell, L. E., Green, M. H. A., Tutt, A. L., Glennie, M. J., & Al‐Shamkhani, A. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200212)32:12 · Cited by 149 · see citing works
Yellin, M. J., Sinning, J. G., Covey, L. R., et al. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.2.666 · Cited by 144 · see citing works
de Jesus, O., Smith, P. R., Spender, L. C., Karstegl, C. E., Niller, H. H., Huang, D. P., & Farrell, P. J. (2003) · Journal of General Virology · doi:10.1099/vir.0.19054-0 · Cited by 124 · see citing works
Multiple Paths for Activation of Naive CD8+ T Cells: CD4-Independent Help
Wang, B., Norbury, C. C., Greenwood, R., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1283 · Cited by 104 · see citing works
Hernandez, M. G. H., Shen, L., & Rock, K. L. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.2844 · Cited by 101 · see citing works
Autophagy in MHC class II antigen processing.
Strawbridge, A. B., & Blum, J. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.11.009 · Cited by 77 · see citing works
CD40 ligand‐positive CD8+ T cell clones allow B cell growth and differentiation
Hermann, P., van Kooten, C., Gaillard, C., et al. (1995) · European Journal of Immunology · doi:10.1002/eji.1830251039 · Cited by 73 · see citing works
Identification and isolation of murine antigen‐reactive T cells according to CD154 expression
Kirchhoff, D., Frentsch, M., Leclerk, P., Bumann, D., Rausch, S., Hartmann, S., Thiel, A., & Scheffold, A. (2007) · European Journal of Immunology · doi:10.1002/eji.200737322 · Cited by 65 · see citing works
Self-citationGeneration of Tumor-associated Cytotoxic T Lymphocytes Requires Interleukin 4 from CD8+ T Cells
Schüler, T., Kammertoens, T., Preiß, S., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.12.1767 · Cited by 64 · see citing works
Sad, S., Krishnan, L., Bleackley, R. C., Kägi, D., Hengartner, H., & Mosmann, T. R. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270417 · Cited by 61 · see citing works
Biesen, R., Dähnrich, C., Rosemann, A., et al. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3250 · Cited by 47 · see citing works
Memory CD8+ T Cells Protect Dendritic Cells from CTL Killing
Watchmaker, P. B., Urban, J. A., Berk, E., Nakamura, Y., Mailliard, R. B., Watkins, S. C., van Ham, S. M., & Kaliński, P. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.6.3857 · Cited by 44 · see citing works
CD4+ T Cells Can Protect APC from CTL-Mediated Elimination
Mueller, S. N., Jones, C. M., Stock, A. T., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.12.7379 · Cited by 41 · see citing works
A Role for IFN-γ from Antigen-Specific CD8+ T Cells in Protective Immunity to Listeria monocytogenes
Messingham, K. N., Badovinac, V. P., Jabbari, A., & Harty, J. T. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2457 · Cited by 36 · see citing works
Hernandez, M. G. H., Shen, L., & Rock, K. L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4382 · Cited by 35 · see citing works
CD40L‐expressing CD8 T cells prime CD8α+ DC for IL‐12p70 production
Wong, K. L., Lew, F. C., MacAry, P. A., et al. (2008) · European Journal of Immunology · doi:10.1002/eji.200838199 · Cited by 33 · see citing works
CD40L co‐stimulation from CD8 + to CD4 + effector memory T cells supports CD4 + expansion
Xydia, M., Ge, Y., Quitsch, U., & Beckhove, P. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.153 · Cited by 12 · see citing works
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- Authors
- Frentsch, M., Stark, R., Matzmohr, N., Meier, S., Durlanik, S., Schulz, A. R., Stervbo, U., Jürchott, K., Gebhardt, F., Heine, G., Reuter, M. A., Betts, M. R., Busch, D., & Thiel, A.
- Affiliations
- Berlin-Brandenburger Centrum für Regenerative Therapien (DE)
- Humboldt-Universität zu Berlin (DE)
- Technical University of Munich (DE)
- Charité – Universitätsmedizin Berlin (DE)
- University of Pennsylvania (US)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2013-07-18
- Volume
- 122
- Issue
- 3
- Pages
- 405-412
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC4548794
- OpenAlex
- W2034804331
- Cited by
- 100
- References
- 41
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 7 · 2023: 9 · 2022: 4 · 2021: 9 · 2020: 13 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 12 · 2015: 9 · 2014: 9 · 2013: 3
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI076066)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- CD40 ligand, CD8+ T cells, T cell help, MHC class I-restricted T cells, antigen-presenting cell activation, cytokine expression, influenza virus, yellow fever virus, memory T cells, cytotoxic T lymphocytes, immunotherapy
- MeSH terms
- Animals, Epitopes, Cytotoxicity, Immunologic, T-Lymphocytes, Helper-Inducer, Humans, Immunologic Memory, Mice, Inbred C57BL, Immunophenotyping, Cytokines, CD8-Positive T-Lymphocytes, CD40 Ligand, Mice
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