CoChat
Sign Up
Cited by 297T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesHIV Research and Treatment

Human CD8+ T-cell differentiation in response to viruses

van Lier, René A. W., ten Berge, Ineke J. M., Gamadia, Laila E.·2003·Nature Reviews Immunology
DOI 10.1038/nri1254
Open this paper in CoChat — free account

Integrity signals

Registry

Crossref · 10.1038/nri1254

Cites

105 of 105 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Late-stage differentiated effector memory CD4+ and CD8+ T cells accumulate with ageing and many are specific for latent Herpes viruses, especially Cytomegalovirus (CMV).

    “Late-stage differentiated effector memory CD4+ and CD8+ T cells accumulate with ageing and many are specific for latent Herpes viruses, especially Cytomegalovirus (CMV) (van Lier et al. 2003).”

    From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as van Lier et al. 2003

  • CMV-specific T cells exhibit a late-stage differentiated phenotype, including loss of co-stimulatory molecules (e.g., CD27 and CD28) and cell-surface proteins associated with homing to lymphoid tissue (e.g., CD62L and CCR7).

    “These CMV-specific T cells exhibit a late-stage differentiated phenotype, including loss of co-stimulatory molecules (e.g., CD27 and CD28) and cell-surface proteins associated with homing to lymphoid tissue (e.g., CD62L and CCR7) (Appay et al. 2008; van Lier et al. 2003).”

    From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as van Lier et al. 2003

  • These cells re-express CD45RA in combination with markers often stated to reflect 'senescence' such as CD57 and KLRG1.

    “Further, these cells re-express CD45RA in combination with markers often stated to reflect “senescence” such as CD57 and KLRG1 (Appay et al. 2008; van Lier et al. 2003).”

    From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as van Lier et al. 2003

  • From an evolutionary perspective, there may be an advantage to having an accumulation of late-stage differentiated T cells, assuming few are senescent/functionally exhausted, and considering that many will be specific for viruses such as CMV that require constant immune-surveillance.

    “From an evolutionary perspective, there may be an advantage to having an accumulation of late-stage differentiated T cells, assuming few are senescent/functionally exhausted, and considering that many will be specific for viruses such as CMV that require constant immune-surveillance (van Lier et al. 2003).”

    From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as van Lier et al. 2003

  • TEMRA cells generally become dysfunctional.

    “Generally, it is TEMRA cells that become dysfunctional (Fulop et al. 2013; van Lier et al. 2003)”

    From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as van Lier et al. 2003

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
van Lier, R. A. W., ten Berge, I. J. M., & Gamadia, L. E.
Affiliations
Amsterdam UMC Location University of Amsterdam (NL)
Venue
Nature Reviews Immunology
Publisher
Springer Science and Business Media LLC
Published
2003-12
Volume
3
Issue
12
Pages
931-939
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
DOI
10.1038/nri1254
OpenAlex
W2105579166
Cited by
297
References
104
Citations by year
2026: 3 · 2025: 3 · 2024: 6 · 2023: 10 · 2022: 2 · 2021: 5 · 2020: 7 · 2018: 5 · 2017: 8 · 2016: 12 · 2015: 16 · 2014: 13 · 2013: 17 · 2012: 14
FWCI
1.88
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords
CD8+ T cells, T cell differentiation, viral infection, T cell development, latent viruses, T cell heterogeneity, acute viral infection, antiviral immunity
MeSH terms
Animals, Cell Differentiation, Humans, Immunologic Memory, Lymphocyte Activation, Viruses, T-Lymphocyte Subsets, Virus Latency, CD8-Positive T-Lymphocytes, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review