Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans

Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans

den Braber, I., Mugwagwa, T., Vrisekoop, N., Westera, L., Mögling, R., Bregje de Boer, A., Willems, N., Schrijver, E. H. R., Spierenburg, G., Gaiser, K., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.02.006 · Cited by 572

Increased Turnover of T Lymphocytes in HIV-1 Infection and Its Reduction by Antiretroviral Therapy

Mohri, H., Perelson, A. S., Tung, K. S., Ribeiro, R. M., Ramratnam, B., Markowitz, M. H., Kost, R. G., Hurley, Weinberger, L. S., Cesar, D., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.9.1277 · Cited by 359

Measurement in vivo of proliferation rates of slow turnover cells by 2 H 2 O labeling of the deoxyribose moiety of DNA

Neese, R. A., Misell, L. M., Turner, S., Chu, A., Kim, J., Cesar, D., Hoh, R., Antelo, F., Strawford, A., McCune, J. M., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232551499 · Cited by 279

Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection

Hellerstein, M. K., Hoh, R., Hanley, M. B., Cesar, D., Lee, D. C., Neese, R. A., & McCune, J. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317533 · Cited by 243

Quantifying T lymphocyte turnover

de Boer, R. J., & Perelson, A. S. (2013) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2012.12.025 · Cited by 242

Sparse production but preferential incorporation of recently produced naïve T cells in the human peripheral pool

Vrisekoop, N., den Braber, I., de Boer, A. B., Ruiter, A. F. C., Ackermans, M. T., van der Crabben, S. N., Schrijver, E. H. R., Spierenburg, G. T., Sauerwein, H. P., Hazenberg, M. D., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709713105 · Cited by 229

In vivo dynamics of T cell activation, proliferation, and death in HIV-1 infection: Why are CD4 + but not CD8 + T cells depleted?

Ribeiro, R. M., Mohri, H., Ho, D. D., & Perelson, A. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242358099 · Cited by 199

Rapid Turnover of Effector–Memory CD4+ T Cells in Healthy Humans

Macallan, D. C., Wallace, D. L., Zhang, Y., de Lara, C., Worth, A. T., Ghattas, H., Griffin, G. E., Beverley, P. C. L., & Tough, D. F. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040341 · Cited by 193

Measurement of cell proliferation by heavy water labeling

Busch, R., Neese, R. A., Awada, M., Hayes, G. M., & Hellerstein, M. K. (2007) · Nature Protocols · doi:10.1038/nprot.2007.420 · Cited by 184

Measurement and modeling of human T cell kinetics

Macallan, D. C., Asquith, B., Irvine, A. J., Wallace, D. L., Worth, A. T., Ghattas, H., Zhang, Y., Griffin, G. E., Tough, D. F., & Beverley, P. C. L. (2003) · European Journal of Immunology · doi:10.1002/eji.200323763 · Cited by 129

CD52‐negative T cells predict acute graft‐versus‐host disease after an alemtuzumab‐based conditioning regimen

Wölfinger, P., Epp, K., Schaefer, L., Kriege, D., Theobald, M., Bopp, T., & Wagner‐Drouet, E. (2020) · British Journal of Haematology · doi:10.1111/bjh.16706 · Cited by 3

Impact on in-depth immunophenotyping of delay to peripheral blood processing

Higdon, L. E., Scheiding, S., Kus, A. M., Lim, N., Long, S. A., Anderson, M. S., & WIEDEMAN, A. E. (2024) · Clinical & Experimental Immunology · doi:10.1093/cei/uxae041 · Cited by 6

Parameter estimation and treatment optimization in a stochastic model for immunotherapy of cancer

Diabaté, M., Coquille, L., & Samson, A. (2020) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2020.110359 · Cited by 3

The Memory-CD8+-T-Cell Response to Conserved Influenza Virus Epitopes in Mice Is Not Influenced by Time Since Previous Infection

Lanfermeijer, J., van de Ven, K., Hendriks, M., van Dijken, H., Lenz, S., Vos, M. W., Borghans, J. A. M., van Baarle, D., & de Jonge, J. (2024) · Vaccines · doi:10.3390/vaccines12040419 · Cited by 5

How are estimated cellular turnover rates influenced by the dynamics of a source population?

Swain, A. C., Borghans, J. A. M., & de Boer, R. J. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1013052 · Cited by 2

An evolutionary stability perspective on oncogenesis control in mature T-cell populations

Diebner, H. H., Kirberg, J., & Roeder, I. (2015) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2015.10.033 · Cited by 2

The dynamics of the HIV-1 latent reservoir – considering the heterogeneous subpopulationsPreprint

Ke, R., & Deng, K. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/541961 · Cited by 2

A Multi-Stage Model of Cell Proliferation and Death: Tracking Cell Divisions with Erlang DistributionsPreprint

Belluccini, G., López‐García, M., Lythe, G., & Molina-Parı́s, C. (2021) · Research Square · doi:10.21203/rs.3.rs-1112337/v1 · Cited by 2

Tissue resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and replacement from precursorsPreprint

Chandler, J. S., Bullock, M. E., Swain, A. C., Williams, C., van Dorp, C. H., Seddon, B. P., & Yates, A. J. (2025) · eLife · doi:10.7554/elife.104278.1 · Cited by 2

The landscape of genetic medicines for in vivo T cell reprogramming

(1953121), J. B. S., Lemgart, V. T., Kulkarni, J. A., & Witzigmann, D. (2026) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2026.115940 · Cited by 1

An in-host HIV-1 infection model incorporating quiescent and activated CD4 + T cells as well as CTL response

Sutimin, S., Wijaya, K. P., Chávez, J. P., & Tian, T. (2021) · Applied Mathematics and Computation · doi:10.1016/j.amc.2021.126410 · Cited by 1

The impact of model assumptions in interpreting cell kinetic studies

Yan, A. W. C., Sadreev, I. I., Mackerodt, J., Zhang, Y., Macallan, D. C., Busch, R., & Asquith, B. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1012704 · Cited by 1

Variation in DNA enrichment among deuterium labeling studies is largely explained by different background corrections

Şanal, E., Borghans, J. A. M., & de Boer, R. J. (2025) · Journal of Immunological Methods · doi:10.1016/j.jim.2025.113987 · Cited by 1

Analysis of Single Bacterium Dynamics in a Stochastic Model of Toxin-Producing Bacteria

Paterson, J., López‐García, M., Gillard, J. J., Laws, T. R., Lythe, G., & Molina-Parı́s, C. (2021) · Lecture notes in computer science · doi:10.1007/978-3-030-91825-5_13 · Cited by 1

A novel antibody targeting ICOS increases intratumoural cytotoxic to regulatory T cell ratio and induces tumour regressionPreprint

Sainson, R. C. A., Thotakura, A. K., Kosmač, M., Borhis, G., Parveen, N., Kimber, R., Carvalho, J., Henderson, S. C., Pryke, K. L., Okell, T., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/771493 · Cited by 1

Oral Porphyromonas gingivalis Infection Induces Epigenetic Changes that Promote Persistence of Cardiovascular Disease Risk

Lehmann, K. (2020) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3-1yjt-en58 · Cited by 2

Tissue resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacementPreprint

Chandler, J. S., Bullock, M. E., Swain, A. C., Williams, C., van Dorp, C. H., Seddon, B. P., & Yates, A. J. (2025) · eLife · doi:10.7554/elife.104278.2 · Cited by 1

Constraints and tunability of antigen-agnostic memory durabilityPreprint

Tripathi, S., Liu, C., Lau, W. W., Sparks, R., & Tsang, J. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.18.663399 · Cited by 1

Off-target effects of Cre recombinase reveal limits of adoptive T cell transfers and persistent proliferation of effector CD8 T-cellsPreprint

Borkner, L., Drabig, A., Zheng, X., Drylewicz, J., Marandu, T. F., Baliu‐Piqué, M., van Duikeren, S., Arens, R., Tesselaar, K., Borghans, J. A. M., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/502666

Impact of cytomegalovirus-infection on ageing of the immune system

Berg, S. (2020) · Utrecht University Repository (Utrecht University) · doi:10.33540/66

Patient profiling and prediction of response to immune-modulating treatment in moderate-to-severe atopic dermatitis

Bakker, D. S. (2021) · Utrecht University Repository (Utrecht University) · doi:10.33540/905

Turnover of MCMV-expanded CD8 + T-cells is similar to that of memory phenotype T-cells and independent of the magnitude of the responsePreprint

Baliu‐Piqué, M., Drylewicz, J., Zheng, X., Borkner, L., Swain, A. C., Otto, S. A., de Boer, R. J., Tesselaar, K., Čičin‐Šain, L., & Borghans, J. A. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.03.467089

Let's be adaptable

Lutter, L. (2022) · Utrecht University Repository (Utrecht University) · doi:10.33540/1160

Ink Trails

Swain, A. C. (2023) · doi:10.33540/1850

Cell-Mediated Immunity

Kamperschroer, C., Collinge, M., Heyen, J. R., Ji, C., O’Donnell, L. M., & Zhu, X. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00104-2

Stochastic journeys of cell progenies through compartments and the role of self-renewal, symmetric and asymmetric division

Dreiwi, H., Feliciangeli, F., Castro, M., Lythe, G., Molina-Parı́s, C., & López-García, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-63500-2

İmmünobiyoloji

Bozdoğan, Ö. (2024) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.3250

Tissue-resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacementPreprint

Chandler, J. S., Bullock, M. E., Swain, A. C., Williams, C., van Dorp, C. H., Seddon, B. P., & Yates, A. J. (2025) · eLife · doi:10.7554/elife.104278

Antigen-specific Th17 T cells offset the age-related decline in durable T cell immunityPreprint

Sturmlechner, I., Jain, A. K., Jiang, J., Okuyama, H., Mu, Y., Own, M., Weyand, C. M., & Goronzy, J. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.05.658069

Dependence of the amplification factor on the body water deuterium enrichment

Şanal, E., Drylewicz, J., Tesselaar, K., Asquith, B., Borghans, J. A. M., & de Boer, R. J. (2025) · Journal of Immunological Methods · doi:10.1016/j.jim.2025.114010

Détection et quantification des ADN non intégrés linéaires responsables de la latence pré-intégrative du VIH-1

Roux, H. (2022) · theses.fr (ABES) · doi:10.70675/2f861d9fz0cc1z4031z905ez94f9066db0fe

Compétition entre cellules cancéreuses et cellules du système immunitaire : l’apport de la théorie cinétique

Masurel, L. (2021) · theses.fr (ABES) · doi:10.70675/615b4da6z5fb0z43e4z9f2bz1ccdfd6efae7

Hybrid Systems Modeling of Donor T‐Cell Responses and Graft‐Versus‐Host‐Disease After Posttransplantation Cyclophosphamide Administration

Fan, H., McCune, J. S., Kanakry, C. G., & Mager, D. E. (2026) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.70252

Model-Aided Quantification of Patient-Specific Benefit in Mitigating Radiation-Induced Lymphopenia by Particle Therapy of Cancer

Sandul, V., Durante, M., & Friedrich, T. (2026) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2026.08.022

Mechanisms accounting for Allee effects during HIV-1 infection

de Boer, R. J., & Perelson, A. S. (2026) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2026.112579

Коли сльозозамінників уже недостатньо: місце протизапальної терапії циклоспорином А при синдромі «сухого ока»

Н.С., С. (2026) · Український медичний часопис · doi:10.32471/umj.1680-3051.281841

Current best estimates for the average lifespans of mouse and human leukocytes: reviewing two decades of deuterium‐labeling experiments

Borghans, J. A. M., Tesselaar, K., & de Boer, R. J. (2018) · Immunological Reviews · doi:10.1111/imr.12693 · Cited by 53

Leukocyte dynamics in mice and men

den Braber, A. J. (2006) · Utrecht University Repository (Utrecht University)

Current estimates of T cell kinetics in humans

Macallan, D. C., Busch, R., & Asquith, B. (2019) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2019.10.002 · Cited by 43

Human T cell lifespan (P1284)

Réu, P., Mold, J. E., Michaëlsson, J., Salehpour, M., & Frisén, J. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.190.supp.119.1

Revealing the dynamics of immune cells in humans: mechanistic modelling of deuterium labelling data

Lahoz-Beneytez, J. (2016) · Spiral (Imperial College London) · doi:10.25560/68511