Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans

Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans

den Braber, I., Mugwagwa, T., Vrisekoop, N., Westera, L., Mögling, R., Bregje de Boer, A., Willems, N., Schrijver, E. H. R., Spierenburg, G., Gaiser, K., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.02.006 · Cited by 572

Increased Turnover of T Lymphocytes in HIV-1 Infection and Its Reduction by Antiretroviral Therapy

Mohri, H., Perelson, A. S., Tung, K. S., Ribeiro, R. M., Ramratnam, B., Markowitz, M. H., Kost, R. G., Hurley, Weinberger, L. S., Cesar, D., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.9.1277 · Cited by 359

Measurement in vivo of proliferation rates of slow turnover cells by 2 H 2 O labeling of the deoxyribose moiety of DNA

Neese, R. A., Misell, L. M., Turner, S., Chu, A., Kim, J., Cesar, D., Hoh, R., Antelo, F., Strawford, A., McCune, J. M., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232551499 · Cited by 279

Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection

Hellerstein, M. K., Hoh, R., Hanley, M. B., Cesar, D., Lee, D. C., Neese, R. A., & McCune, J. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317533 · Cited by 243

Quantifying T lymphocyte turnover

de Boer, R. J., & Perelson, A. S. (2013) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2012.12.025 · Cited by 242

Sparse production but preferential incorporation of recently produced naïve T cells in the human peripheral pool

Vrisekoop, N., den Braber, I., de Boer, A. B., Ruiter, A. F. C., Ackermans, M. T., van der Crabben, S. N., Schrijver, E. H. R., Spierenburg, G. T., Sauerwein, H. P., Hazenberg, M. D., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709713105 · Cited by 229

In vivo dynamics of T cell activation, proliferation, and death in HIV-1 infection: Why are CD4 + but not CD8 + T cells depleted?

Ribeiro, R. M., Mohri, H., Ho, D. D., & Perelson, A. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242358099 · Cited by 199

Rapid Turnover of Effector–Memory CD4+ T Cells in Healthy Humans

Macallan, D. C., Wallace, D. L., Zhang, Y., de Lara, C., Worth, A. T., Ghattas, H., Griffin, G. E., Beverley, P. C. L., & Tough, D. F. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040341 · Cited by 193

Measurement of cell proliferation by heavy water labeling

Busch, R., Neese, R. A., Awada, M., Hayes, G. M., & Hellerstein, M. K. (2007) · Nature Protocols · doi:10.1038/nprot.2007.420 · Cited by 184

Measurement and modeling of human T cell kinetics

Macallan, D. C., Asquith, B., Irvine, A. J., Wallace, D. L., Worth, A. T., Ghattas, H., Zhang, Y., Griffin, G. E., Tough, D. F., & Beverley, P. C. L. (2003) · European Journal of Immunology · doi:10.1002/eji.200323763 · Cited by 129

The who's who of T ‐cell differentiation: Human memory T ‐cell subsets

Mahnke, Y. D., Brodie, T. M., Sallusto, F., Roederer, M., & Lugli, E. (2013) · European Journal of Immunology · doi:10.1002/eji.201343751 · Cited by 817

Origin and differentiation of human memory CD8 T cells after vaccination

Akondy, R. S., Fitch, M., Edupuganti, S., Yang, S., Kissick, H. T., Li, K. W., Youngblood, B. A., Abdelsamed, H. A., McGuire, D. J., Cohen, K. W., et al. (2017) · Nature · doi:10.1038/nature24633 · Cited by 517

Mechanisms underlying T cell ageing

Goronzy, J. J., & Weyand, C. M. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0180-1 · Cited by 506

L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling

Ívetic, A., Green, H. L. H., & Hart, S. J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01068 · Cited by 493

Successful and Maladaptive T Cell Aging

Goronzy, J. J., & Weyand, C. M. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.010 · Cited by 362

Post-treatment control of HIV infection

Conway, J. M., & Perelson, A. S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419162112 · Cited by 227

How many TCR clonotypes does a body maintain?

Lythe, G., Callard, R. E., Hoare, R. L., & Molina-París, C. (2016) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2015.10.016 · Cited by 175

The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options

Periman, L. M., Perez, V. L., Saban, D. R., Lin, M. C., & Neri, P. (2020) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2019.0060 · Cited by 174

Advances in NK cell production

Fang, F., Xie, S., Chen, M., Li, Y., Yue, J., Ma, J., Shu, X., He, Y., Xiao, W., & Tian, Z. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00808-3 · Cited by 132

Mouse aging cell atlas analysis reveals global and cell type-specific aging signatures

Zhang, M. J., Pisco, A. O., Darmanis, S., & Zou, J. (2021) · eLife · doi:10.7554/elife.62293 · Cited by 121

Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging

Säwen, P., Eldeeb, M., Erlandsson, E., Kristiansen, T. A., Laterza, C., Kokaia, Z., Karlsson, G., Yuan, J., Soneji, S., Mandal, P. K., et al. (2018) · eLife · doi:10.7554/elife.41258 · Cited by 120

Fluctuating fitness shapes the clone-size distribution of immune repertoires

Desponds, J., Mora, T., & Walczak, A. M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512977112 · Cited by 96

Strategies to eradicate HIV from infected patients: elimination of latent provirus reservoirs

Sadowski, I., & Hashemi, F. B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03156-8 · Cited by 106

Lymphocyte maintenance during healthy aging requires no substantial alterations in cellular turnover

Westera, L., van Hoeven, V., Drylewicz, J., Spierenburg, G., van Velzen, J. F., de Boer, R. J., Tesselaar, K., & Borghans, J. A. M. (2015) · Aging Cell · doi:10.1111/acel.12311 · Cited by 96

Carbon Monoxide: from Poison to Clinical Trials

Siracusa, R., Schaufler, A., Calabrese, V., Fuller, P. M., & Otterbein, L. E. (2021) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.02.003 · Cited by 99

Mechanisms of HBV immune evasion

Kuipery, A., Gehring, A. J., & Isogawa, M. (2020) · Antiviral Research · doi:10.1016/j.antiviral.2020.104816 · Cited by 87

Human T Cell Memory: A Dynamic View

Macallan, D. C., Borghans, J. A. M., & Asquith, B. (2017) · Vaccines · doi:10.3390/vaccines5010005 · Cited by 77

Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels

Gossel, G. H., Hogan, T. V., Cownden, D., Seddon, B. P., & Yates, A. J. (2017) · eLife · doi:10.7554/elife.23013 · Cited by 77

Immune Aging and Immunotherapy in Cancer

Kaiser, M., Semeraro, M. D., Herrmann, M., Absenger, G., Gerger, A., & Renner, W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137016 · Cited by 79

Clay Nanoparticles Elicit Long‐Term Immune Responses by Forming Biodegradable Depots for Sustained Antigen Stimulation

Chen, W., Zuo, H., Li, B., Duan, C., Rolfe, B. E., Zhang, B., Mahony, T. J., & Xu, Z. P. (2018) · Small · doi:10.1002/smll.201704465 · Cited by 77

Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness

del Amo, P. C., Lahoz-Beneytez, J., Boelen, L., Ahmed, R., Miners, K. L., Zhang, Y., Roger, L., Jones, R. E., Marraco, S. A. F., Speiser, D. E., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005523 · Cited by 76

Efficient and Durable Vaccine against Intimin β of Diarrheagenic E. Coli Induced by Clay Nanoparticles

Chen, W., Zhang, B., Mahony, T. J., Gu, W., Rolfe, B. E., & Xu, Z. P. (2016) · Small · doi:10.1002/smll.201503359 · Cited by 74

Residual Viremia in Treated HIV+ Individuals

Conway, J. M., & Perelson, A. S. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004677 · Cited by 67

Development of a Target cell-Biologics-Effector cell (TBE) complex-based cell killing model to characterize target cell depletion by T cell redirecting bispecific agents

Jiang, X., Chen, X., Carpenter, T. J., Wang, J., Zhou, R., Davis, H. M., Heald, D. L., & Wang, W. (2018) · mAbs · doi:10.1080/19420862.2018.1480299 · Cited by 60

Clonal dynamics after allogeneic haematopoietic cell transplantation

Spencer Chapman, M., Wilk, C. M., Boettcher, S., Mitchell, E., Dawson, K., Williams, N., Müller, J., Kovtonyuk, L., Jung, H., Caiado, F., et al. (2024) · Nature · doi:10.1038/s41586-024-08128-y · Cited by 60

Chronic Kidney Disease and Premature Ageing of the Adaptive Immune Response

Betjes, M. G. H., & Litjens, N. H. R. (2014) · Current Urology Reports · doi:10.1007/s11934-014-0471-9 · Cited by 58

Temporal fate mapping reveals age-linked heterogeneity in naive T lymphocytes in mice

Hogan, T. V., Gossel, G. H., Yates, A. J., & Seddon, B. P. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1517246112 · Cited by 56

Current best estimates for the average lifespans of mouse and human leukocytes: reviewing two decades of deuterium‐labeling experiments

Borghans, J. A. M., Tesselaar, K., & de Boer, R. J. (2018) · Immunological Reviews · doi:10.1111/imr.12693 · Cited by 53

Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial

Denk, D., Singh, A., Kasler, H. G., D’Amico, D., Rey, J., Alcober-Boquet, L., Gorol, J. M., Steup, C., Tiwari, R., Kwok, R., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00996-x · Cited by 58

Lifitegrast for the treatment of dry eye disease in adults

Donnenfeld, E. D., Perry, H. D., Nattis, A. S., & Rosenberg, E. D. (2017) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2017.1372748 · Cited by 49

Mathematics in modern immunology

Castro, M., Lythe, G., Molina-Parı́s, C., & Ribeiro, R. M. (2016) · Interface Focus · doi:10.1098/rsfs.2015.0093 · Cited by 49

Short Lifespans of Memory T-cells in Bone Marrow, Blood, and Lymph Nodes Suggest That T-cell Memory Is Maintained by Continuous Self-Renewal of Recirculating Cells

Baliu‐Piqué, M., Verheij, M. W., Drylewicz, J., Ravesloot, L., de Boer, R. J., Koets, A. P., Tesselaar, K., & Borghans, J. A. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02054 · Cited by 48

Innate Immunity Plays a Key Role in Controlling Viral Load in COVID-19: Mechanistic Insights from a Whole-Body Infection Dynamics Model

Dogra, P., Ruiz-Ramírez, J., Sinha, K., Butner, J. D., Peláez, M. J., Rawat, M., Yellepeddi, V., Pasqualini, R., Arap, W., Sostman, H. D., et al. (2020) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00183 · Cited by 45

Integrating between-host transmission and within-host immunity to analyze the impact of varicella vaccination on zoster

Ogunjimi, B., Willem, L., Beutels, P., & Hens, N. (2015) · eLife · doi:10.7554/elife.07116 · Cited by 42

Current estimates of T cell kinetics in humans

Macallan, D. C., Busch, R., & Asquith, B. (2019) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2019.10.002 · Cited by 43

Quantification of T-cell dynamics during latent cytomegalovirus infection in humans

van den Berg, S. P. H., Derksen, L. Y., Drylewicz, J., Nanlohy, N. M., Beckers, L., Lanfermeijer, J., Gessel, S., Vos, M. W., Otto, S. A., de Boer, R. J., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1010152 · Cited by 40

Lifitegrast Ophthalmic Solution 5% Is a Safe and Efficient Eyedrop for Dry Eye Disease: A Systematic Review and Meta-Analysis

Li, J., Tsai, Y., Lai, C., Li, Y., Wu, Y.-H., & Chiang, C.-C. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11175014 · Cited by 40

Rates of CTL Killing in Persistent Viral Infection In Vivo

Elemans, M., Florins, A., Willems, L., & Asquith, B. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003534 · Cited by 37

Heterogeneity of memory T cells in aging

Jain, A. K., Sturmlechner, I., Weyand, C. M., & Goronzy, J. J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1250916 · Cited by 34

T cell fate decisions during memory cell generation with aging

Sturmlechner, I., Jain, A. K., Mu, Y., Weyand, C. M., & Goronzy, J. J. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101800 · Cited by 32

Quantification of naive and memory T-cell turnover during HIV-1 infection

Vrisekoop, N., Drylewicz, J., van Gent, R., Mugwagwa, T., van Lelyveld, S. F. L., Veel, E., Otto, S. A., Ackermans, M. T., Vermeulen, J. N., Huidekoper, H. H., et al. (2015) · AIDS · doi:10.1097/qad.0000000000000822 · Cited by 31

Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples

Liechti, T., Iftikhar, Y., Mangino, M., Beddall, M. H., Goss, C. W., O’Halloran, J. A., Mudd, P. A., & Roederer, M. (2022) · Nature Communications · doi:10.1038/s41467-022-34638-2 · Cited by 32

Fc Effector Function of Immune Checkpoint Blocking Antibodies in Oncology

Martineau, R., Susini, S., & Marabelle, A. (2024) · Immunological Reviews · doi:10.1111/imr.13427 · Cited by 27

Modeling the immune response to HIV infection

Conway, J. M., & Ribeiro, R. M. (2018) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2018.10.006 · Cited by 29

Bone marrow is the preferred site of memory CD4+ T cell proliferation during recovery from sepsis

Skirecki, T., Swacha, P., Hoser, G., Gołąb, J., Nowis, D., & Kozłowska, E. (2020) · JCI Insight · doi:10.1172/jci.insight.134475 · Cited by 27

Reconciling Estimates of Cell Proliferation from Stable Isotope Labeling Experiments

Ahmed, R., Westera, L., Drylewicz, J., Elemans, M., Zhang, Y., Kelly, E. W., Reljić, R., Tesselaar, K., de Boer, R. J., Macallan, D. C., et al. (2015) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004355 · Cited by 26

Development of a minimal physiologically-based pharmacokinetic/pharmacodynamic model to characterize target cell depletion and cytokine release for T cell-redirecting bispecific agents in humans

Jiang, X., Chen, X., Jaiprasart, P., Carpenter, T. J., Zhou, R. Z., & Wang, W. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105260 · Cited by 26

Modeling T Cell Fate

de Boer, R. J., & Yates, A. J. (2023) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101721-040924 · Cited by 29

Memories that last: Dynamics of memory T cells throughout the body

Derksen, L. Y., Tesselaar, K., & Borghans, J. A. M. (2023) · Immunological Reviews · doi:10.1111/imr.13211 · Cited by 28

Mathematical model for the growth of Mycobacterium tuberculosis in the granuloma

Burbano-Rosero, E. M., Esteva, L., & Ibargüen-Mondragón, E. (2017) · Mathematical Biosciences & Engineering · doi:10.3934/mbe.2018018 · Cited by 24

Environmentally relevant exposures of male mice to carbendazim and thiram cause persistent genotoxicity in male mice

Rai, B., & Mercurio, S. D. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-07088-5 · Cited by 23

Absence of autoreactive CD4+ T-cells targeting HLA-DQA1*01:02/DQB1*06:02 restricted hypocretin/orexin epitopes in narcolepsy type 1 when detected by EliSpot

Kornum, B. R., Burgdorf, K. S., Holm, A., Ullum, H., Jennum, P., & Knudsen, S. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.05.001 · Cited by 22

Early HIV RNA decay during raltegravir-containing regimens exhibits two distinct subphases (1a and 1b)

Andrade, A. S., Guedj, J., Rosenkranz, S. L., Lu, D., Mellors, J. W., Kuritzkes, D. R., Perelson, A. S., & Ribeiro, R. M. (2015) · AIDS · doi:10.1097/qad.0000000000000843 · Cited by 21

Role of Axl in T-Lymphocyte Survival in Salt-Dependent Hypertension

Batchu, S. N., Hughson, A., Wadosky, K. M., Morrell, C. N., Fowell, D. J., & Korshunov, V. A. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307848 · Cited by 21

Brief exposure to hyperglycemia activates dendritic cells in vitro and in vivo

Thomas, A. M., Dong, Y., Beskid, N. M., Garcı́a, A. J., Adams, A. B., & Babensee, J. E. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29380 · Cited by 20

Mechanistic prediction of first-in-human dose for bispecific CD3/EpCAM T-cell engager antibody M701, using an integrated PK/PD modeling method

Song, L., Xue, J., Zhang, J., Li, S., Liu, D., & Zhou, T. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105584 · Cited by 19

Liquid Chromatography–Mass Spectrometry Analysis of Frataxin Proteoforms in Whole Blood as Biomarkers of the Genetic Disease Friedreich’s Ataxia

Rojsajjakul, T., Wu, L., Grady, C. B., Hwang, W., Mesaros, C., Lynch, D. R., & Blair, I. A. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c00091 · Cited by 19

Development of a multiscale mechanistic modeling framework integrating differential cellular kinetics of CAR T‐ cell subsets and immunophenotypes in cancer patients

Salem, A. M., Mugundu, G. M., & Singh, A. P. (2023) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.13009 · Cited by 21

Determinants of the efficacy of HIV latency-reversing agents and implications for drug and treatment design

Ke, R., Conway, J. M., Margolis, D. M., & Perelson, A. S. (2018) · JCI Insight · doi:10.1172/jci.insight.123052 · Cited by 21

Predicting chromosome damage in astronauts participating in international space station missions

Feiveson, A., George, K., Shavers, M., Moreno-Villanueva, M., Zhang, Y., Babiak-Vazquez, A., Crucian, B., Semones, E., & Wu, H. (2021) · Scientific Reports · doi:10.1038/s41598-021-84242-5 · Cited by 19

The maths of memory

Borghans, J. A. M., & Ribeiro, R. M. (2017) · eLife · doi:10.7554/elife.26754 · Cited by 17

Dynamics of Recent Thymic Emigrants in Young Adult Mice

van Hoeven, V., Drylewicz, J., Westera, L., den Braber, I., Mugwagwa, T., Tesselaar, K., Borghans, J. A. M., & de Boer, R. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00933 · Cited by 16

Fate-mapping mice: new tools and technology for immune discovery

Lee, S. E., Rudd, B. D., & Smith, N. L. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.01.004 · Cited by 15

Mécanismes de la lymphopénie radio-induite et implications thérapeutiques

Césaire, M., Mauff, B. L., Rambeau, A., Toutirais, O., & Thariat, J. (2020) · Bulletin du Cancer · doi:10.1016/j.bulcan.2020.04.009 · Cited by 16

Homeostasis and Durability of T-Cell Memory—The Resting and the Restless T-Cell Memory

Radbruch, A., McGrath, M. A., Siracusa, F., Hoffmann, U., Sercan-Alp, Ö., Hutloff, A., Tokoyoda, K., Chang, H.-D., & Dong, J. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a038083 · Cited by 16

Quantifying T Cell Cross-Reactivity: Influenza and Coronaviruses

Gaevert, J. A., Duque, D. L., Lythe, G., Molina-Parı́s, C., & Thomas, P. G. (2021) · Viruses · doi:10.3390/v13091786 · Cited by 13

Emergence and competition of virus variants in respiratory viral infections

Bessonov, N., Neverova, D., Попов, В. А., & Volpert, V. A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.945228 · Cited by 15

CTLA4-Ig in combination with FTY720 promotes allograft survival in sensitized recipients

Khiew, S. H. W., Yang, J., Young, J. S., Chen, J., Wang, Q., Yin, D., Vu, V., Miller, M. L., Sciammas, R., Alegre, M., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.92033 · Cited by 15

Cell-Mediated Immunity

Kamperschroer, C., Collinge, M., Heyen, J. R. R., Ji, C., O’Donnell, L. M., & Zhu, X. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64229-0 · Cited by 15

Dynamics and turnover of memory CD8 T cell responses following yellow fever vaccination

Zarnitsyna, V. I., Akondy, R. S., Ahmed, H., McGuire, D. J., Zarnitsyn, V. G., Moore, M., Johnson, P. L. F., Ahmed, R., Li, K. W., Hellerstein, M. K., et al. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009468 · Cited by 16

Mitochondrial proteomics profile points oxidative phosphorylation as main target for beauvericin and enniatin B mixture

Alonso-Garrido, M., Manyes, L., Pralea, I.-E., & Iuga, C. A. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111432 · Cited by 14

Physiologically Based Simulations of Deuterated Glucose for Quantifying Cell Turnover in Humans

Lahoz-Beneytez, J., Schaller, S., Macallan, D. C., Eißing, T., Niederalt, C., & Asquith, B. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00474 · Cited by 13

Cell-density independent increased lymphocyte production and loss rates post-autologous HSCT

Baliu‐Piqué, M., van Hoeven, V., Drylewicz, J., van der Wagen, L. E., Janssen, A., Otto, S. A., van Zelm, M. C., de Boer, R. J., Kuball, J. H. E., Borghans, J. A. M., et al. (2021) · eLife · doi:10.7554/elife.59775 · Cited by 12

Effect of lymphoid volume irradiation on radiation-induced lymphopenia in head and neck cancers

Césaire, M., Rambeau, A., Cherifi, F., Géry, B., Johnson, A., Nacher, M., & Thariat, J. (2023) · Cancer/Radiothérapie · doi:10.1016/j.canrad.2022.08.008 · Cited by 12

TGF-β Signaling Supports HIV Latency in a Memory CD4+ T Cell Based In Vitro Model

Bergstresser, S., & Kulpa, D. A. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-1871-4_6 · Cited by 10

Fate of a Naive T Cell: A Stochastic Journey

de la Higuera, L., López‐García, M., Castro, M., Abourashchi, N., Lythe, G., & Molina-Parı́s, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00194 · Cited by 11

Counting generations in birth and death processes with competing Erlang and exponential waiting times

Belluccini, G., López‐García, M., Lythe, G., & Molina-Parı́s, C. (2022) · Scientific Reports · doi:10.1038/s41598-022-14202-0 · Cited by 11

The Hayflick Limit May Determine the Effective Clonal Diversity of Naive T Cells

Ndifon, W. O., & Dushoff, J. G. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502343 · Cited by 12

Gαs, adenylyl cyclase, and their relationship to the diagnosis and treatment of depression

Schappi, J. M., & Rasenick, M. M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1012778 · Cited by 11

High Mutation Frequency of the PIGA Gene in T Cells Results in Reconstitution of GPI Anchor−/CD52− T Cells That Can Give Early Immune Protection after Alemtuzumab-Based T Cell–Depleted Allogeneic Stem Cell Transplantation

Loeff, F. C., Falkenburg, J. H. F., Hageman, L., Huisman, W., Veld, S. A. J., van Egmond, H. M. E., van de Meent, M., Borne, P. A. V. D., Veelken, H., Halkes, C. J. M., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701018 · Cited by 11

The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host

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Age-related distribution and dynamics of T-cells in blood and lymphoid tissues of goats

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In vivo deuterium labelling in mice supports a dynamic model for memory T-cell maintenance in the bone marrow

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Turnover of Murine Cytomegalovirus–Expanded CD8+ T Cells Is Similar to That of Memory Phenotype T Cells and Independent of the Magnitude of the Response

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Space-velocity thermostatted kinetic theory model of tumor growth

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T and NK Cells in IL2RG-Deficient Patient 50 Years After Hematopoietic Stem Cell Transplantation

Melsen, J. E., Dam, M. M. V. O.-T., van den Akker, E. B., Welters, M. J. P., Heezen, K. C., Pico‐Knijnenburg, I., Kolijn, P. M., Bredius, R. G. M., van Doorn, R., Langerak, A. W., et al. (2022) · Journal of Clinical Immunology · doi:10.1007/s10875-022-01279-5 · Cited by 6

The Rules of Human T Cell Fate in vivo

del Amo, P. C., Debebe, J., Razavi-Mohseni, M., Nakaoka, S., Worth, A. T., Wallace, D. L., Beverley, P. C. L., Macallan, D. C., & Asquith, B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00573 · Cited by 7

Nanoparticle-Based Delivery of Anaplasma marginale Membrane Proteins; VirB9-1 and VirB10 Produced in the Pichia pastoris Expression System

Zhang, B., Cavallaro, A., Mody, K. T., Zhang, J., Deringer, J. R., Brown, W. C., Mahony, T. J., Yu, C., & Mitter, N. (2016) · Nanomaterials · doi:10.3390/nano6110201 · Cited by 7

Ibrutinib exposure correlates with improved efficacy of CAR T cells in patients with mantle cell lymphoma

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In Vitro Priming of Human T Cells by Dendritic Cells Provides a Screening Tool for Candidate Vaccines for Burkholderia pseudomallei

Reddi, D., Durant, L. R., Bernardo, D., Noble, A., English, N. R., Hendy, P., Clark, G. C., Prior, J. L., Williamson, E. D., & Knight, S. C. (2021) · Vaccines · doi:10.3390/vaccines9080929 · Cited by 6

Antigen-specific T H 17 cells offset the age-related decline in durable T cell immunity

Sturmlechner, I., Jain, A. K., Jiang, J., Okuyama, H., Mu, Y., Own, M., Weyand, C. M., & Goronzy, J. J. (2026) · Science Advances · doi:10.1126/sciadv.aea7131 · Cited by 5

Tissue-resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacement

Chandler, J. S., Bullock, M. E., Swain, A. C., Williams, C., van Dorp, C. H., Seddon, B. P., & Yates, A. J. (2025) · eLife · doi:10.7554/elife.104278.3 · Cited by 5

Immunosuppressive effect and global dysregulation of blood transcriptome in response to psychosocial stress in vervet monkeys (Chlorocebus sabaeus)

Jasinska, A. J., Pandrea, I., He, T., Benjamin, C., Newton, M., Lee, J. C., Freimer, N. B., Coppola, G., & Jentsch, D. (2020) · Scientific Reports · doi:10.1038/s41598-020-59934-z · Cited by 5

Defects in Long-Term APC Repopulation Ability of Adult Human Bone Marrow Hematopoietic Stem Cells (HSCs) Compared with Fetal Liver HSCs

Nauman, G., Danzl, N. M., Lee, J., Borsotti, C., Madley, R., Fu, J., Hölzl, M. A., Dahmani, A., Dorronsoro, A., Chavez, É., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100966 · Cited by 5

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Long-term impact of antiretroviral strategies for a functional HIV cure: A virtual clinical trial

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Thymus

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Mouse Aging Cell Atlas Analysis Reveals Global and Cell Type Specific Aging Signatures Revision 1Preprint

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Geometric immunosuppression in CAR T-cell treatment: Insights from mathematical modeling

Bordel-Vozmediano, S., Sabir, S., Benito-Barca, L., Weigelin, B., & Pérez‐García, V. M. (2025) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2025.110427 · Cited by 3

Current best estimates for the average lifespans of mouse and human leukocytes: reviewing two decades of deuterium‐labeling experiments

Borghans, J. A. M., Tesselaar, K., & de Boer, R. J. (2018) · Immunological Reviews · doi:10.1111/imr.12693 · Cited by 53

Leukocyte dynamics in mice and men

den Braber, A. J. (2006) · Utrecht University Repository (Utrecht University)

Current estimates of T cell kinetics in humans

Macallan, D. C., Busch, R., & Asquith, B. (2019) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2019.10.002 · Cited by 43

Human T cell lifespan (P1284)

Réu, P., Mold, J. E., Michaëlsson, J., Salehpour, M., & Frisén, J. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.190.supp.119.1

Revealing the dynamics of immune cells in humans: mechanistic modelling of deuterium labelling data

Lahoz-Beneytez, J. (2016) · Spiral (Imperial College London) · doi:10.25560/68511