Cited by 172Blood Coagulation and Thrombosis MechanismsCircadian rhythm and melatoninBlood properties and coagulation

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Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle

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Scheer, Frank A. J. L., Shea, Steven A.·2014·Blood

DOI 10.1182/blood-2013-07-517060PMC PMC3901072

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Abstract

Key Points: The human circadian system causes a morning peak in circulating levels of PAI-1, independent of any behavioral or environmental influences. The circadian system determines to a large extent the PAI-1 rhythm observed during a regular sleep/wake cycle.

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Authors: Scheer, F. A. J. L., & Shea, S. A.
Affiliations: Brigham and Women's Hospital (US)
ORCID: Scheer, Frank A. J. L.
Shea, Steven A.
Venue: Blood
Publisher: American Society of Hematology
Published: 2014-01-23
Volume: 123
Issue: 4
Pages: 590-593
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2013-07-517060
PMC: PMC3901072
OpenAlex: W2054542782
Cited by: 172
References: 23
Citations by year: 2026: 12 · 2025: 11 · 2024: 14 · 2023: 15 · 2022: 15 · 2021: 17 · 2020: 9 · 2019: 23 · 2018: 12 · 2017: 8 · 2016: 13 · 2015: 14 · 2014: 9
FWCI: 8.53
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Blood (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (K24HL076446, R01HL076409, P30HL101299)
National Center for Research Resources (UL1RR025758)
Topics: Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Hematology › Blood properties and coagulation
Keywords: plasminogen activator inhibitor-1, circadian rhythm, morning peak, prothrombotic factors, fibrinolysis, sleep-wake cycle, cardiovascular events, head-up tilt, physical activity, posture, circadian system
MeSH terms: Adult, Behavior, Blood Coagulation, Circadian Rhythm, Female, Fibrinolysis, Gene Expression Regulation, Humans, Male, Risk Factors, Sleep, Temperature, Time Factors, Wakefulness, Exercise, Plasminogen Activator Inhibitor 1, Young Adult

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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle

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