Major circadian fluctuations in fibrinolytic factors and possible relevance to time of onset of myocardial infarction, sudden cardiac death and stroke
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Highest platelet aggregability and highest concentration of plasminogen activator inhibitor-1 (PAI-1) occur in the morning.
“For instance, highest platelet aggregability and highest concentration of plasminogen activator inhibitor-1 (PAI-1) occur in the morning (109, 110).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [110]
Cites
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Evidence of a diurnal fibrinolytic rhythm; with a simple method of measuring natural fibrinolysis.
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Day–Night Pattern of Sudden Death in Obstructive Sleep Apnea
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Role of the circadian system in cardiovascular disease
Thosar, S. S., Butler, M. P., & Shea, S. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci80590 · Cited by 443 · see citing works
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Early Morning Attenuation of Endothelial Function in Healthy Humans
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Circadian variation in stroke onset: identical temporal pattern in ischemic and hemorrhagic events
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Circadian variation in vascular tone and endothelial cell function in normal males
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Reactivity of Ambulatory Blood Pressure to Physical Activity Varies With Time of Day
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Circadian rhythm and cardiovascular disease
Shaw, E., & Tofler, G. H. (2009) · Current Atherosclerosis Reports · doi:10.1007/s11883-009-0044-4 · Cited by 55 · see citing works
- Authors
- Andreotti, F., Davies, G. J., Hackett, D. R., Khan, M. I., De Bart, A. C. W., Aber, V. R., Maseri, A., & Kluft, C.
- Affiliations
- Netherlands Organisation for Applied Scientific Research (NL)
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 1988-09
- Volume
- 62
- Issue
- 9
- Pages
- 635-637
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2041493322
- Cited by
- 422
- References
- 8
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 8 · 2020: 4 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 8 · 2013: 12 · 2012: 10
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- TNO Repository (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Keywords
- circadian rhythm, fibrinolysis, tissue plasminogen activator, plasminogen activator inhibitor, morning surge, myocardial infarction, sudden cardiac death, stroke, thrombosis, hemostasis
- MeSH terms
- Adult, Cerebrovascular Disorders, Circadian Rhythm, Death, Sudden, Female, Fibrinolysis, Glycoproteins, Humans, Male, Myocardial Infarction, Tissue Plasminogen Activator, Plasminogen Activators, Plasminogen Inactivators
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