The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Conditioning regimens for hematopoietic cell transplantation: one size does not fit all
Open accessAbstract
An essential component of allogeneic and autologous hematopoietic cell transplantation (HCT) is the conditioning regimen administered before the hematopoietic cell infusion. Early regimens relied on dose intensity, assuming that high-dose chemoradiotherapy would eliminate malignant disease and reinfusion of the graft would then restore hematopoiesis. However, as the contribution of graft-versus-tumor effects to the success of allogeneic HCT was recognized over time, in an effort to exploit these, many investigators lowered the dose of radiation and chemotherapeutic agents in the preparative regimen. This resulted in a major paradigm shift, and consequently, the pool of eligible patients underwent a remarkable expansion. In this article, we provide a review of the definition of high-dose, reduced-intensity, and nonmyeloablative conditioning regimens, the most commonly used agents and combinations, and the evolution of some early regimens. We also provide a brief review of the toxicities associated with these regimens.
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Cites
Graft-versus-leukemia reactions after bone marrow transplantation
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Self-citationAntileukemic Effect of Graft-versus-Host Disease in Human Recipients of Allogeneic-Marrow Grafts
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Metadata
- Authors
- Gyurkocza, B., & Sandmaier, B. M.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2014-07-17
- Volume
- 124
- Issue
- 3
- Pages
- 344-353
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1996320020
- Cited by
- 614
- References
- 67
- FWCI
- 18.98
- Type
- journal article
- Language
- en
- Open access
- green
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