The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy
Open accessAbstract
Key Points: In people with cystic fibrosis, defective CFTR function alters neutrophil cytosolic ion homeostasis leading to impaired degranulation. By normalizing CFTR function, ivacaftor treatment corrects neutrophil degranulation resulting in normalized killing of bacteria.
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Citations
Cites
Getting to the site of inflammation: the leukocyte adhesion cascade updated
Ley, K., Laudanna, C., Cybulsky, M. I., & Nourshargh, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2156 · Cited by 4,354
A CFTR Potentiator in Patients with Cystic Fibrosis and the G551D Mutation
Ramsey, B. W., Davies, J., McElvaney, N. G., Tullis, E., Bell, S. C., Dřevínek, P., Griese, M., McKone, E. F., Wainwright, C. E., Konstan, M. W., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1105185 · Cited by 2,195
Self-citationKilling activity of neutrophils is mediated through activation of proteases by K+ flux
Reeves, E. P., Lu, H., Jacobs, H. L., Messina, C. G. M., Bolsover, S., Gabella, G., Potma, E. O., Warley, A., Roes, J., & Segal, A. W. (2002) · Nature · doi:10.1038/416291a · Cited by 1,153
Self-citationComparing two small samples with an unstable, treatment-independent baseline
Janušonis, S. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.01.017 · Cited by 49
Cited by
Peng, S., Stojkov, D., Gao, J., Oberson, K., Latzin, P., Casaulta, C., Yousefi, S., & Simon, H.-U. (2022) · PLOS Biology · doi:10.1371/journal.pbio.3001794 · Cited by 15
Metadata
- Authors
- Pohl, K., Hayes, E., Keenan, J., Henry, M., Meleady, P., Molloy, K., Jundi, B., Bergin, D. A., McCarthy, C., McElvaney, O. J., White, M. M., Clynes, M., Reeves, E. P., & McElvaney, N. G.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2014-08-14
- Volume
- 124
- Issue
- 7
- Pages
- 999-1009
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1988413334
- Cited by
- 163
- References
- 4
- FWCI
- 12.12
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy. https://app.cochat.ai/papers/10.1182/blood-2014-02-555268
- The paper
- Pohl, K., Hayes, E., Keenan, J., Henry, M., Meleady, P., Molloy, K., Jundi, B., Bergin, D. A., McCarthy, C., McElvaney, O. J., White, M. M., Clynes, M., Reeves, E. P., & McElvaney, N. G. (2014). A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy. Blood. https://doi.org/10.1182/blood-2014-02-555268
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
