The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.
The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma
Open accessAbstract
Key Points: Afuresertib has a favorable safety profile with manageable side effects and demonstrates single-agent activity against hematologic malignancies. Inhibition of AKT with afuresertib may provide a novel therapeutic strategy for hematologic malignancies, especially for multiple myeloma.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Afuresertib, an oral AKT inhibitor, has been studied as a single agent in MM. It has shown a favorable safety profile in clinical trials, suggesting that AKT inhibition may be a viable therapeutic strategy for MM patients [70].”
From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [70]
Citations
Cites
Revised Response Criteria for Malignant Lymphoma
Cheson, B. D., Pfistner, B., Juweid, M. E., Gascoyne, R. D., Specht, L., Horning, S. J., Coiffier, B., Fisher, R. I., Hagenbeek, A., Zucca, E., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.09.2403 · Cited by 4,452
Hallek, M. J., Cheson, B. D., Catovsky, D., Caligaris‐Cappio, F., Dighiero, G., Döhner, H., Hillmen, P., Keating, M. J., Montserrat, E., Rai, K. R., et al. (2008) · Blood · doi:10.1182/blood-2007-06-093906 · Cited by 3,782
Cheson, B. D., Bennett, J. M., Kopecky, K. J., Büchner, T., Willman, C. L., Estey, E. H., Schiffer, C. A., Döhner, H., Tallman, M. S., Lister, T. A., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.04.036 · Cited by 2,686
International uniform response criteria for multiple myeloma
Durie, B. G. M., Harousseau, J.-L., Miguel, J. S., Bladé, J., Barlogie, B., Anderson, K., Gertz, M., Dimopoulos, M., Westin, J., Sonneveld, P., et al. (2006) · Leukemia · doi:10.1038/sj.leu.2404284 · Cited by 2,632
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
Engelman, J. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2664 · Cited by 2,445
Palumbo, A. P., & Anderson, K. C. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1011442 · Cited by 2,382
Raje, N. S., & Anderson, K. C. (2000) · Current Treatment Options in Oncology · doi:10.1007/s11864-000-0017-x · Cited by 2,164
Creutzig, U., & Kaspers, G. J. L. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.99.116 · Cited by 2,137
Initial genome sequencing and analysis of multiple myeloma
Chapman, M. A., Lawrence, M. S., Keats, J. J., Cibulskis, K., Sougnez, C. L., Schinzel, A. C., Harview, C. L., Brunet, J.-P., Ahmann, G. J., Adli, M., et al. (2011) · Nature · doi:10.1038/nature09837 · Cited by 1,457
Baccarani, M., Cortes, J. E., Pane, F., Niederwieser, D. W., Saglio, G. N., Apperley, J. F., Cervantes, F., Deininger, M. W., Gratwohl, A. A., Guilhot, F., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.25.0779 · Cited by 1,276
Cited by
Sorted by citations
Items 101–143 of 143
Hausmann, S., Brandt, E., Köchel, C., Einsele, H., Bargou, R. C., Seggewiß-Bernhardt, R., & Stühmer, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122689 · Cited by 5
Yu, Z., Wang, H., & You, G. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115702 · Cited by 4
Ji, X., Miao, L., Wu, Y., Zhao, T., Si, Y., Tan, X., Zhou, Q., Zuo, R., Pei, J., Wu, J., et al. (2024) · Biology Methods and Protocols · doi:10.1093/biomethods/bpae014 · Cited by 5
Sun, W., Sun, J., Hu, W., Luo, C., Lu, Z., He, F., Zhao, H., Zeng, X., Cao, D., Li, J., et al. (2024) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-024-04736-7 · Cited by 4
Sadeghi, F., Afkhami, A., Madrakian, T., & Ghavami, R. (2021) · SAR and QSAR in environmental research · doi:10.1080/1062936x.2021.1891568 · Cited by 4
The role of Capon in multiple myeloma
Shen, Y., Liu, H., Gu, S., Wei, Z., & Liu, H. (2017) · Tumor Biology · doi:10.1177/1010428317713674 · Cited by 4
Wang, C., He, Z.-M., Shi, Y.-Y., Zhang, L., Chen, Y., Chen, Z., & Yu, L. (2017) · Hematology · doi:10.1080/10245332.2016.1234186 · Cited by 4
Resistance Mechanisms to Novel Therapies in Myeloma
Wallington-Beddoe, C. T., & Coghlan, D. W. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.77004 · Cited by 3
Tseng, C.-Y., Fu, Y.-H., Ou, D., Hou, H., Chien, H., & Lin, L. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118689 · Cited by 2
Zhang, P., Sun, T., Wang, Y., Wei, L. I., Tong, Z., Phadke, S. D., Feinstein, T. M., Ma, W., Guo, P., Zhang, M., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-69225-2 · Cited by 2
Drug Resistance Analysis of Pancreatic Cancer Based on Universally Differentially Expressed Genes
Xia, J., LinYong, Z., Zhang, H., Fan, Q., Liu, H., Wang, O., & Yan, H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26093936 · Cited by 2
Wang, H., Baladandayuthapani, V., Wang, Z., Lin, H. Y., Berkova, Z., Davis, R. E., Yang, L., & Orlowski, R. Z. (2017) · Oncotarget · doi:10.18632/oncotarget.23017 · Cited by 2
Novel Targets in Multiple Myeloma
Chari, A. (2015) · American Journal of Hematology / Oncology® · Cited by 2
Biology and Genomics of LCH and Related Disorders
Rollins, B. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-59632-7_2 · Cited by 2
Zhang, H., Yang, L., Liu, Y., Wang, D., Shi, L., & Tian, C. (2025) · Discover Oncology · doi:10.1007/s12672-025-02383-9 · Cited by 1
Purcell, E., Dowling, P., O’Gorman, P., & Bazou, D. (2025) · Blood Reviews · doi:10.1016/j.blre.2025.101360 · Cited by 1
In silico evaluation of herbal inhibitors against AKT isoforms as potential anticancer agents
Öz, H. (2026) · Discover Chemistry. · doi:10.1007/s44371-025-00440-4 · Cited by 1
Kolosova, A., Mould, I. A., Pepper, C. J., Mitchell, S., Pepper, A. G. S., Ladikou, E. E., & Simoes, F. A. (2026) · Blood and Lymphatic Cancer Targets and Therapy · doi:10.2147/blctt.s511758 · Cited by 1
Leleu, X. P. (2014) · Blood · doi:10.1182/blood-2014-08-593822 · Cited by 1
New drugs on the horizon. Treatment of myeloma in 2020, a perspective
Ludwig, H., Hilbe, W., & Zojer, N. (2015) · memo - Magazine of European Medical Oncology · doi:10.1007/s12254-014-0194-0 · Cited by 1
Treatment of Patients in Third Relapse and Beyond Including Double-Refractory Disease
Tremblay, D. A., Leng, S., & Chari, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-61872-2_6 · Cited by 1
Stamou, M. I., Chen, C. T., Wander, S. A., Supko, J. G., Juric, D., Bardia, A., & Wexler, D. J. (2022) · JCO Precision Oncology · doi:10.1200/po.21.00428 · Cited by 1
Self-citationThe Role of PI3K/AKT/mTOR Inhibitors in the Treatment of Hematological Malignancies
Shen, Z., & Kelly, K. R. (2015) · Springer eBooks · doi:10.1007/978-2-8178-0492-7_7
Targeted Therapies in Mesothelioma
Urso, L., & Pasello, G. (2019) · Springer eBooks · doi:10.1007/978-3-030-16884-1_17
Regulation of Chaperone-Mediated Autophagy by PI3K Signaling
Ziemba, Z. (2020) · Deep Blue (University of Michigan)
Mutation-dependent treatment approaches for patients with complex multiple myeloma
Theodorakakou, F., Dimopoulos, M. A., & Kastritis, E. (2021) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2021.1893605
Development of a 3D in Vitro Disease Model for Multiple Myeloma
Trujillo, S. C. (2022) · RiuNet (Universitat Politècnica de València) · doi:10.4995/thesis/10251/186054
Pharmacologic Differentiation of Drugs Targeting the PI 3K‐ AKT ‐m TOR Signaling Pathway
Ahn, I. E., Brown, A. J. R., & Davids, M. S. (2023) · doi:10.1002/9781119819950.ch6
ตรีสุวรรณ, ส., & พงศ์เรขนานนท์, ว. (2017) · Chula Digiverse · doi:10.58837/chula.the.2017.652
ADiffGDA: Exploring Gene-Drug Associations via Adaptive Graph Diffusion Networks
Zhang, C., Fan, Y., Hu, X., Qian, Y., & Deng, L. (2024) · IEEE International Conference on Bioinformatics and Biomedicine (BIBM) · doi:10.1109/bibm62325.2024.10821876
Oxidative Kinetic Resolution of Alkyl-Substituted 1,2-Diamines
Kan, L., Xu, Z., Ji, Y., Liu, H., Liu, L., & Wang, G. (2025) · Organic Letters · doi:10.1021/acs.orglett.5c01875
AGDNGDA: Unraveling Drug-Associated Genes with Adaptive Graph Diffusion Networks
Hu, X., Zhang, C., Fan, Y., Wu, K., & Deng, L. (2025) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5c02276
AKT as a Therapeutic Target in Cancer
Myint, K. N., & Vivanco, I. (2025) · Current topics in microbiology and immunology · doi:10.1007/82_2025_334 · Cited by 1
Chen, R., Gümüş, N., Jearranaiprepame, S., Whitby, A., Rahman, R., & Kim, D. (2025) · The Analyst · doi:10.1039/d5an00461f
Hirano, M., Imai, Y., Kaito, Y., Murayama, T., Sato, K., Ishida, T., Yamamoto, J., Ito, T., Futami, M., Ri, M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14303001
Hirano, M., Imai, Y., Kaito, Y., Murayama, T., Sato, K., Ishida, T., Yamamoto, J., Ito, T., Futami, M., Ri, M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14303004
Hirano, M., Imai, Y., Kaito, Y., Murayama, T., Sato, K., Ishida, T., Yamamoto, J., Ito, T., Futami, M., Ri, M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14303007
Hodson, D. J., Shouse, G., Shin, H., Salar, A., Bobillo, S., Ribrag, V., Macpherson, N. A., Cordoba, R., Kim, J. S., Guidez, S., et al. (2025) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-25-2239
Liang, J., Xie, Z., Sun, Y., Tang, Y., Gul, S., Qi, Q., Pang, J., Chen, Y., Wang, H., Zhang, J., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177712
BindingDB (2025) · UC San Diego · doi:10.7270/q20v8jd8
Metadata
- Authors
- Spencer, A., Yoon, S.-S., Harrison, S. J., Morris, S. R., Smith, D. A., Brigandi, R. A., Gauvin, J., Kumar, R., Opalinska, J. B., & Chen, C.
- Affiliations
- The Alfred Hospital (AU)
- Seoul National University Hospital (KR)
- The University of Melbourne (AU)
- GlaxoSmithKline (United States) (US)
- Princess Margaret Cancer Centre (CA)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2014-10-02
- Volume
- 124
- Issue
- 14
- Pages
- 2190-2195
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC4229853
- OpenAlex
- W2094611598
- Cited by
- 142
- References
- 28
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 12 · 2023: 7 · 2022: 15 · 2021: 11 · 2020: 9 · 2019: 17 · 2018: 17 · 2017: 11 · 2016: 13 · 2015: 10 · 2014: 2
- FWCI
- 8.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- GlaxoSmithKline
- Topics
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Keywords
- AKT inhibitors, multiple myeloma, PI3K/Akt signaling, hematologic malignancies, maximum tolerated dose, pharmacokinetics, safety, adverse events, non-Hodgkin lymphoma, Langerhans cell histiocytosis, Hodgkin's disease, drug resistance
- MeSH terms
- Administration, Oral, Adolescent, Adult, Aged, Aged, 80 and over, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Multiple Myeloma, Pyrazoles, Thiophenes, Time Factors, Hematologic Neoplasms, Maximum Tolerated Dose, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt, Young Adult, Patient Safety
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review