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The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma
Open accessAbstract
Key Points: Afuresertib has a favorable safety profile with manageable side effects and demonstrates single-agent activity against hematologic malignancies. Inhibition of AKT with afuresertib may provide a novel therapeutic strategy for hematologic malignancies, especially for multiple myeloma.
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“Afuresertib, an oral AKT inhibitor, has been studied as a single agent in MM. It has shown a favorable safety profile in clinical trials, suggesting that AKT inhibition may be a viable therapeutic strategy for MM patients [70].”
From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [70]
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Metadata
- Authors
- Spencer, A., Yoon, S.-S., Harrison, S. J., Morris, S. R., Smith, D. A., Brigandi, R. A., Gauvin, J., Kumar, R., Opalinska, J. B., & Chen, C.
- Affiliations
- The Alfred Hospital (AU)
- Seoul National University Hospital (KR)
- The University of Melbourne (AU)
- GlaxoSmithKline (United States) (US)
- Princess Margaret Cancer Centre (CA)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2014-10-02
- Volume
- 124
- Issue
- 14
- Pages
- 2190-2195
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC4229853
- OpenAlex
- W2094611598
- Cited by
- 142
- References
- 28
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 12 · 2023: 7 · 2022: 15 · 2021: 11 · 2020: 9 · 2019: 17 · 2018: 17 · 2017: 11 · 2016: 13 · 2015: 10 · 2014: 2
- FWCI
- 8.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- GlaxoSmithKline
- Topics
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Keywords
- AKT inhibitors, multiple myeloma, PI3K/Akt signaling, hematologic malignancies, maximum tolerated dose, pharmacokinetics, safety, adverse events, non-Hodgkin lymphoma, Langerhans cell histiocytosis, Hodgkin's disease, drug resistance
- MeSH terms
- Administration, Oral, Adolescent, Adult, Aged, Aged, 80 and over, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Multiple Myeloma, Pyrazoles, Thiophenes, Time Factors, Hematologic Neoplasms, Maximum Tolerated Dose, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt, Young Adult, Patient Safety
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