Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1

Umezu, Tomohiro; Tadokoro, Hiroko; Azuma, Kenko; Yoshizawa, Seiichiro; Ohyashiki, Kazuma; Ohyashiki, Junko H.

doi:10.1182/blood-2014-05-576116

Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1

Key Points We established hypoxia-resistant cells that can mimic in vivo conditions of hypoxic bone marrow. Exosomal miR-135b derived from these cell lines enhanced endothelial tube formation under hypoxia via the HIF-FIH signaling pathway.