The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
How I treat hemophagocytic lymphohistiocytosis in the adult patient
Open accessAbstract
Hemophagocytic lymphohistiocytosis (HLH) is a devastating disorder of uncontrolled immune activation characterized by clinical and laboratory evidence of extreme inflammation. This syndrome can be caused by genetic mutations affecting cytotoxic function (familial HLH) or be secondary to infectious, rheumatologic, malignant, or metabolic conditions (acquired HLH). Prompt recognition is paramount and, without early treatment, this disorder is frequently fatal. Although HLH is well described in the pediatric population, less is known about the appropriate work-up and treatment in adults. Here, we review the clinical characteristics, diagnosis, and treatment of HLH in adults.
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Cites
An integrated map of genetic variation from 1,092 human genomes
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HLH‐2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis
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Adult haemophagocytic syndrome
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Perforin Gene Defects in Familial Hemophagocytic Lymphohistiocytosis
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How I treat hemophagocytic lymphohistiocytosis
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Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome
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Etoposide: four decades of development of a topoisomerase II inhibitor
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Cited by
Chimeric antigen receptor T-cell therapy—assessment and management of toxicities
Neelapu, S. S., Tummala, S., Kebriaei, P., Wierda, W., Gutierrez, C., Locke, F. L., Komanduri, K. V., Lin, Y., Jain, N., Daver, N., et al. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.148 · Cited by 2,438
Thompson, J. A., Schneider, B. J., Brahmer, J., Achufusi, A., Armand, P., Berkenstock, M. K., Bhatia, S., Budde, L. E., Chokshi, S., Davies, M., et al. (2022) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2022.0020 · Cited by 426
A consensus review on malignancy‐associated hemophagocytic lymphohistiocytosis in adults
Daver, N., McClain, K., Allen, C. E., Parikh, S. A., Otrock, Z., Rojas‐Hernandez, C., Blechacz, B., Wang, S., Minkov, M., Jordan, M. B., et al. (2017) · Cancer · doi:10.1002/cncr.30826 · Cited by 258
Metadata
- Authors
- Schram, A. M., & Berliner, N.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2015-05-07
- Volume
- 125
- Issue
- 19
- Pages
- 2908-2914
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2068646465
- Cited by
- 414
- References
- 70
- FWCI
- 21.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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