Cited by 194Acute Lymphoblastic Leukemia researchChildhood Cancer Survivors' Quality of LifeCancer-related cognitive impairment studies

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Chemotherapy-only treatment effects on long-term neurocognitive functioning in childhood ALL survivors: a review and meta-analysis

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Iyer, Neel S., Balsamo, Lyn M., Bracken, Michael B., Kadan-Lottick, Nina S.·2015·Blood

DOI 10.1182/blood-2015-02-627414

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Abstract

Key Points: Children treated for ALL without cranial radiation display significant IQ deficits of 6 to 8 points compared with healthy controls. Moderate deficits occur in other neurocognitive domains including working memory, information processing speed, and fine motor functioning.

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Authors: Iyer, N. S., Balsamo, L. M., Bracken, M. B., & Kadan-Lottick, N. S.
Affiliations: Lake Erie College of Osteopathic Medicine (US)
Yale Cancer Center (US)
Yale University (US)
Pediatric Hematology/Oncology, Yale School of Medicine and Yale Cancer Center, New Haven, CT; and
ORCID: Iyer, Neel S.
Balsamo, Lyn M.
Kadan-Lottick, Nina S.
Venue: Blood
Publisher: American Society of Hematology
Published: 2015-07-16
Volume: 126
Issue: 3
Pages: 346-353
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2015-02-627414
OpenAlex: W1888049586
Cited by: 194
References: 66
Citations by year: 2026: 14 · 2025: 11 · 2024: 14 · 2023: 16 · 2022: 9 · 2021: 27 · 2020: 20 · 2019: 22 · 2018: 17 · 2017: 19 · 2016: 20 · 2015: 4
FWCI: 2.89
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Funders: St. Baldrick's Foundation
Topics: Health Sciences › Medicine › Hematology › Acute Lymphoblastic Leukemia research
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Keywords: childhood acute lymphoblastic leukemia, cognitive impairment, intelligence quotient, verbal IQ, performance IQ, working memory, processing speed, fine motor skills, cancer survivors
MeSH terms: Antineoplastic Combined Chemotherapy Protocols, Brain Neoplasms, Child, Cognition Disorders, Humans, Survival Rate, Survivors, Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Chemotherapy-only treatment effects on long-term neurocognitive functioning in childhood ALL survivors: a review and meta-analysis

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