Cited by 194Acute Lymphoblastic Leukemia researchChildhood Cancer Survivors' Quality of LifeCancer-related cognitive impairment studies

The DOI matches its Crossref record; 65 of the 66 references it cites were found in a registry or an index.

Chemotherapy-only treatment effects on long-term neurocognitive functioning in childhood ALL survivors: a review and meta-analysis

Open access

Iyer, Neel S., Balsamo, Lyn M., Bracken, Michael B., Kadan-Lottick, Nina S.·2015·Blood

DOI 10.1182/blood-2015-02-627414

Open this paper in CoChat — free account Open PDF

Abstract

Key Points: Children treated for ALL without cranial radiation display significant IQ deficits of 6 to 8 points compared with healthy controls. Moderate deficits occur in other neurocognitive domains including working memory, information processing speed, and fine motor functioning.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1182/blood-2015-02-627414

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2009.06.005 · Cited by 19,575
Untitled work
(2000) · Cited by 9,198
The file drawer problem and tolerance for null results.
Rosenthal, R. (1979) · Psychological Bulletin · doi:10.1037/0033-2909.86.3.638 · Cited by 9,068
Publication bias in clinical research
Easterbrook, P. J., Gopalan, R., Berlin, J. A., & Matthews, D. R. (1991) · The Lancet · doi:10.1016/0140-6736(91)90201-y · Cited by 3,109
The Existence of Publication Bias and Risk Factors for Its Occurrence
Dickersin, K. (1990) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1990.03440100097014 · Cited by 1,417
Publication bias in meta-analysis its causes and consequences
Thornton, A. (2000) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(99)00161-4 · Cited by 1,291
The Use and Interpretation of Quasi-Experimental Studies in Medical Informatics
Harris, A. D., McGregor, J. C., Perencevich, E. N., Furuno, J. P., Zhu, J., Peterson, D. E., & Finkelstein, J. (2006) · Journal of the American Medical Informatics Association · doi:10.1197/jamia.m1749 · Cited by 1,023 · cited 1×
“Intelligence is consideredan integrationofdifferent neurocognitive functions.(23) When studies reported results for multiple time points, the latest time point was analyzed.”
Background
Executive functions and their disorders
Elliott, R. (2003) · British Medical Bulletin · doi:10.1093/bmb/65.1.49 · Cited by 792

Show all 66 references

Research works printed but not linked: 1

Higgins, Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.2

Sorted by citations

The mutational footprints of cancer therapies
Pich, O., Muiños, F., Lolkema, M. P., Steeghs, N., Gonzalez-Perez, A., & Lopez-Bigas, N. (2019) · Nature Genetics · doi:10.1038/s41588-019-0525-5 · Cited by 309
Understanding the school experiences of children and adolescents with serious chronic illness: a systematic meta‐review
Lum, A., Wakefield, C. E., Donnan, B., Burns, M. A., Fardell, J. E., & Marshall, G. M. (2017) · Child: Care, Health and Development · doi:10.1111/cch.12475 · Cited by 221
Late Effects Surveillance Recommendations among Survivors of Childhood Hematopoietic Cell Transplantation: A Children's Oncology Group Report
Chow, E. J., Anderson, L., Baker, K. S., Bhatia, S., Guilcher, G. M. T., Huang, J. T., Pelletier, W., Perkins, J. L., Rivard, L., Schechter, T., et al. (2016) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2016.01.023 · Cited by 201
Longitudinal Assessment of Neurocognitive Outcomes in Survivors of Childhood Acute Lymphoblastic Leukemia Treated on a Contemporary Chemotherapy Protocol
Jacola, L. M., Krull, K. R., Pui, C.-H., Pei, D., Cheng, C., Reddick, W. E., & Conklin, H. M. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.64.3205 · Cited by 160
Childhood Leukemia and Primary Prevention
Whitehead, T. P., Metayer, C., Wiemels, J. L., Singer, A. W., & Miller, M. D. (2016) · Current problems in pediatric and adolescent health care · doi:10.1016/j.cppeds.2016.08.004 · Cited by 136
Monitoring and Assessment of Neuropsychological Outcomes as a Standard of Care in Pediatric Oncology
Annett, R. D., Patel, S. K., & Phipps, S. (2015) · Pediatric Blood & Cancer · doi:10.1002/pbc.25749 · Cited by 131
Pharmacologic management of cognitive impairment induced by cancer therapy
Karschnia, P., Parsons, M. W., & Dietrich, J. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30938-0 · Cited by 121
Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions
Thastrup, M., Duguid, A., Mirian, C., Schmiegelow, K., & Halsey, C. (2022) · Leukemia · doi:10.1038/s41375-022-01714-x · Cited by 132
Mental health of long‐term survivors of childhood and young adult cancer: A systematic review
Friend, A. J., Feltbower, R. G., Hughes, E., Dye, K. P., & Glaser, A. (2018) · International Journal of Cancer · doi:10.1002/ijc.31337 · Cited by 113
Cognitive, behaviour, and academic functioning in adolescent and young adult survivors of childhood acute lymphoblastic leukaemia: a report from the Childhood Cancer Survivor Study
Jacola, L. M., Edelstein, K., Liu, W., Pui, C., Hayashi, R. J., Kadan‐Lottick, N. S., Srivastava, D. K., Henderson, T. O., Leisenring, W. M., Robison, L. L., et al. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)30283-8 · Cited by 114
Self-citation
Neurodevelopmental consequences of pediatric cancer and its treatment: applying an early adversity framework to understanding cognitive, behavioral, and emotional outcomes
Marusak, H. A., Iadipaolo, A. S., Harper, F. W. K., Elrahal, F., Taub, J. W., Goldberg, E., & Rabinak, C. A. (2017) · Neuropsychology Review · doi:10.1007/s11065-017-9365-1 · Cited by 128
Opportunities, barriers, and recommendations in Down syndrome research
Hendrix, J. A., Amon, A., Abbeduto, L., Agiovlasitis, S., Alsaied, T., Anderson, H. A., Bain, L. J., Baumer, N., Bhattacharyya, A., Bogunovic, D., et al. (2021) · Translational Science of Rare Diseases · doi:10.3233/trd-200090 · Cited by 117
Intellectual Outcome in Molecular Subgroups of Medulloblastoma
Moxon‐Emre, I., Taylor, M. D., Bouffet, É., Hardy, K. K., Campen, C. J., Malkin, D. M., Hawkins, C. E., Laperrière, N., Ramaswamy, V., Bartels, U. K., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.66.9077 · Cited by 94
Central nervous system involvement in acute lymphoblastic leukemia is mediated by vascular endothelial growth factor
Münch, V., Trentin, L., Herzig, J., Demir, S., Seyfried, F., Kraus, J. M., Kestler, H. A., Köhler, R., Barth, T. F. E., Kronnie, G. T., et al. (2017) · Blood · doi:10.1182/blood-2017-03-769315 · Cited by 88
Neurocognitive Effects and Necrosis in Childhood Cancer Survivors Treated With Radiation Therapy: A PENTEC Comprehensive Review
Mahajan, A., Stavinoha, P. L., Rongthong, W., Brodin, N. P., McGovern, S. L., Naqa, I. E., Palmer, J. D., Vennarini, S., Indelicato, D. J., Aridgides, P. D., et al. (2021) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2020.11.073 · Cited by 79
Progress and Prospects in Pediatric Leukemia
Madhusoodhan, P. P., Carroll, W. L., & Bhatla, T. (2016) · Current problems in pediatric and adolescent health care · doi:10.1016/j.cppeds.2016.04.003 · Cited by 72
Social adjustment in adolescent survivors of pediatric central nervous system tumors: A report from the C hildhood C ancer S urvivor S tudy
Schulte, F., Brinkman, T. M., Li, C., Fay‐McClymont, T. B., Srivastava, D. K., Ness, K. K., Howell, R. M., Mueller, S., Wells, E. M., Strother, D. R., et al. (2018) · Cancer · doi:10.1002/cncr.31593 · Cited by 71
Assessment and Monitoring of Neurocognitive Function in Pediatric Cancer
Jacola, L. M., Partanen, M., Lemiere, J., Hudson, M. M., & Thomas, S. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.20.02444 · Cited by 71
Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on stearoyl-CoA desaturase
Savino, A. M., Fernandes, S. I., Olivares, O., Zemlyansky, A., Cousins, A., Markert, E. K., Barel, S., Geron, I., Frishman‐Levy, L., Birger, Y., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-00115-2 · Cited by 70
Cancer Rehabilitation in the Pediatric and Adolescent/Young Adult Population
Tanner, L. R., Keppner, K., Lesmeister, D., Lyons, K., Rock, K., & Sparrow, J. (2020) · Seminars in Oncology Nursing · doi:10.1016/j.soncn.2019.150984 · Cited by 67
Controlling methacryloyl substitution of chondroitin sulfate: injectable hydrogels with tunable long-term drug release profiles
Ornell, K. J., Lozada, D., Phan, N. V., & Coburn, J. M. (2019) · Journal of Materials Chemistry B · doi:10.1039/c8tb03020k · Cited by 62
Brain structure, working memory and response inhibition in childhood leukemia survivors
van der Plas, E., Schachar, R. J., Hitzler, J., Crosbie, J., Guger, S. L., Spiegler, B. J., Ito, S., & Nieman, B. J. (2017) · Brain and Behavior · doi:10.1002/brb3.621 · Cited by 59
“…their impact on quality of life are a crucial concern (KuninBatson, Kadan- Lottick, & Neglia, 2014; Mitchell et al., 2016), making the effort to identify targets for remediating cognitive, and behavioral deficits a pressing issue (Iyer et al., 2015; Kunin- Batson et al., 2014; Olson & Sands, 2015).”
Background
Methotrexate causes persistent deficits in memory and executive function in a juvenile animal model
Wen, J., Maxwell, R. R., Wolf, A. J., Spira, M., Gulinello, M. E., & Cole, P. D. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.07.007 · Cited by 58
Neurocognitive Functioning of Children Treated for High-Risk B-Acute Lymphoblastic Leukemia Randomly Assigned to Different Methotrexate and Corticosteroid Treatment Strategies: A Report From the Children’s Oncology Group
Hardy, K. K., Embry, L. M., Kairalla, J. A., Helian, S., Devidas, M., Armstrong, D., Hunger, S. P., Carroll, W. L., Larsen, E. C., Raetz, E. A., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.71.7587 · Cited by 56
Long‐term risk of cardiovascular mortality in lymphoma survivors: A systematic review and meta‐analysis
Boyne, D. J., Mickle, A. T., Brenner, D. R., Friedenreich, C. M., Cheung, W. Y., Tang, K. L., Wilson, T., Lorenzetti, D., James, M. T., Ronksley, P. E., et al. (2018) · Cancer Medicine · doi:10.1002/cam4.1572 · Cited by 51
Cancer-related cognitive impairment in children
Hutchinson, A. D., Pfeiffer, S. M., & Wilson, C. J. (2016) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000258 · Cited by 51
Total Body Irradiation in Haematopoietic Stem Cell Transplantation for Paediatric Acute Lymphoblastic Leukaemia: Review of the Literature and Future Directions
Hoeben, B. A. W., Wong, J. Y. C., Fog, L. S., Losert, C., Filippi, A. R., Bentzen, S. M., Balduzzi, A., & Specht, L. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.774348 · Cited by 55
Evolution of neurocognitive function in long-term survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only
Liu, W., Cheung, Y. T., Conklin, H. M., Jacola, L. M., Srivastava, D. K., Nolan, V. G., Zhang, H., Gurney, J. G., Huang, I., Robison, L. L., et al. (2018) · Journal of Cancer Survivorship · doi:10.1007/s11764-018-0679-7 · Cited by 50
Agricultural intensification and childhood cancer in Brazil
Skidmore, M. E., Sims, K. M., & Gibbs, H. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2306003120 · Cited by 51
The Brainfit study: efficacy of cognitive training and exergaming in pediatric cancer survivors – a randomized controlled trial
Benzing, V., Eggenberger, N., Spitzhüttl, J. S., Siegwart, V., Pastore‐Wapp, M., Kiefer, C., Slavova, N., Grotzer, M. A., Heinks, T., Schmidt, M., et al. (2018) · BMC Cancer · doi:10.1186/s12885-017-3933-x · Cited by 48
IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia
Alsadeq, A., Lenk, L., Vadakumchery, A., Cousins, A., Vokuhl, C., Khadour, A., Vogiatzi, F., Seyfried, F., Meyer, L. H., Cario, G., et al. (2018) · Blood · doi:10.1182/blood-2018-04-844209 · Cited by 47
Chemotherapy-induced neurotoxicity in pediatric solid non-CNS tumor patients: An update on current state of research and recommended future directions
Sleurs, C., Deprez, S., Emsell, L., Lemiere, J., & Uyttebroeck, A. (2016) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2016.05.001 · Cited by 46
Characterizing neurocognitive late effects in childhood leukemia survivors using a combination of neuropsychological and cognitive neuroscience measures
van der Plas, E. A. A., Erdman, L., Nieman, B. J., Weksberg, R., Butcher, D. T., O’Connor, D. L., Aufreiter, S., Hitzler, J. K., Guger, S., Schachar, R. J., et al. (2017) · Child Neuropsychology · doi:10.1080/09297049.2017.1386170 · Cited by 41
The relationship between cognitive and neuroimaging outcomes in children treated for acute lymphoblastic leukemia with chemotherapy only: A systematic review
Darling, S. J., Seal, M. L., Anderson, V. A., McCarthy, M., Connellan, M., Downie, P., & Luca, C. D. (2016) · Pediatric Blood & Cancer · doi:10.1002/pbc.26188 · Cited by 39
Neurological Complications of the Treatment of Pediatric Neoplastic Disorders
Sun, L. R., & Cooper, S. (2018) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2018.05.011 · Cited by 38
Changes in neurocognitive function and central nervous system structure in childhood acute lymphoblastic leukaemia survivors after treatment: a meta‐analysis
Zhou, C., Zhuang, Y., Lin, X., Michelson, A. D., & Zhang, A. (2019) · British Journal of Haematology · doi:10.1111/bjh.16279 · Cited by 38
Development of an Eco-Biodevelopmental Model of Emergent Literacy Before Kindergarten
Hutton, J., DeWitt, T. G., Hoffman, L., Horowitz‐Kraus, T., & KLASS, P. E. (2021) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2020.6709 · Cited by 43
Cognition, psychosocial functioning, and health-related quality of life among childhood cancer survivors
Siegwart, V., Benzing, V., Spitzhüttl, J. S., Schmidt, M., Grotzer, M. A., Steinlin, M. I., Leibundgut, K., Roebers, C. M., & Everts, R. (2020) · Neuropsychological Rehabilitation · doi:10.1080/09602011.2020.1844243 · Cited by 36
Disrupting the leukemia niche in the central nervous system attenuates leukemia chemoresistance
Jonart, L. M., Ebadi, M., Basile, P., Johnson, K., Makori, J., & Gordon, P. M. (2019) · Haematologica · doi:10.3324/haematol.2019.230334 · Cited by 38
Systemic cisplatin exposure during infancy and adolescence causes impaired cognitive function in adulthood
John, T. D., Lomeli, N., & Bota, D. A. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.11.013 · Cited by 34
Educational attainment of childhood cancer survivors: A systematic review
Molcho, M., D’Eath, M., Thomas, A. A., & Sharp, L. (2019) · Cancer Medicine · doi:10.1002/cam4.2154 · Cited by 33
Network-level dysconnectivity in patients with nasopharyngeal carcinoma (NPC) early post-radiotherapy: longitudinal resting state fMRI study
Qiu, Y., Guo, Z., Han, L., Yang, Y., Li, J., Liu, S., & Lv, X. (2017) · Brain Imaging and Behavior · doi:10.1007/s11682-017-9801-0 · Cited by 33
Brain Connectivity and Cognitive Flexibility in Nonirradiated Adult Survivors of Childhood Leukemia
Billiet, T., Elens, I., Sleurs, C., Uyttebroeck, A., D’Hooge, R., Lemiere, J., & Deprez, S. (2018) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djy009 · Cited by 34
Cognitive and behavioral risk factors for low quality of life in survivors of childhood acute lymphoblastic leukemia
van der Plas, E., Noakes, T. L. S., Butcher, D., Weksberg, R., Galin-Corini, L., Wanstall, E. A., Te, P., Hopf, L., Guger, S. L., Hitzler, J., et al. (2020) · Pediatric Research · doi:10.1038/s41390-020-01230-7 · Cited by 26
Neurocognitive and behavioral outcomes of Chinese survivors of childhood lymphoblastic leukemia
Peng, L., Yang, L. S., Yam, P., Lam, C. S., Chan, A. S.-Y., Li, C. K., & Cheung, Y. T. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.655669 · Cited by 29
Neurologic Complications of Radiation Therapy
Tanguturi, S. K., & Alexander, B. M. (2018) · Neurologic Clinics · doi:10.1016/j.ncl.2018.04.012 · Cited by 29
Childhood cancer, age at diagnosis and educational attainment: A meta-analysis
Gummersall, T., Skaczkowski, G., & Wilson, C. J. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.102838 · Cited by 29
Guidelines for Treatment and Monitoring of Adult Survivors of Pediatric Brain Tumors
Janss, A. J., Mazewski, C., & Patterson, B. C. (2019) · Current Treatment Options in Oncology · doi:10.1007/s11864-019-0602-0 · Cited by 29
Impact of Propofol Exposure on Neurocognitive Outcomes in Children With High-Risk B ALL: A Children's Oncology Group Study
Alexander, S. W., Kairalla, J. A., Gupta, S., Hibbitts, E., Weisman, H. S., Anghelescu, D. L., Winick, N. J., Krull, K. R., Salzer, W. L., Burke, M. J., et al. (2024) · Journal of Clinical Oncology · doi:10.1200/jco.23.01989 · Cited by 31
Tumor-associated myeloid cells provide critical support for T-ALL
Lyu, A., Triplett, T., Nam, S. H., Hu, Z., Arasappan, D., Godfrey, W. H., Ames, R. Y., Sarang, A., Selden, H. J., Lee, C., et al. (2020) · Blood · doi:10.1182/blood.2020007145 · Cited by 31
Flow Cytometric Detection of Malignant Blasts in Cerebrospinal Fluid: A Biomarker of Central Nervous System Involvement in Childhood Acute Lymphoblastic Leukemia
Thastrup, M., Marquart, H. V., & Schmiegelow, K. (2022) · Biomolecules · doi:10.3390/biom12060813 · Cited by 28
Feasibility of baseline neurocognitive assessment using Cogstate during the first month of therapy for childhood leukemia
Sands, S. A., Harel, B. T., Savone, M., Kelly, K. M., Vijayanathan, V., Welch, J. J. G., Vrooman, L. M., Silverman, L. B., & Cole, P. D. (2016) · Supportive Care in Cancer · doi:10.1007/s00520-016-3422-9 · Cited by 28
Protective effect of breastfeeding against childhood leukemia in Zhejiang Province, P. R. China: a retrospective case-control study
Gao, Z., Wang, R., Qin, Z.-X., Dong, A., & Liu, C. (2018) · Libyan Journal of Medicine · doi:10.1080/19932820.2018.1508273 · Cited by 27
A Review of Acute Lymphocytic Leukemia (ALL) in the Pediatric Population: Evaluating Current Trends and Changes in Guidelines in the Past Decade
Ekpa, Q. L., Akahara, P. C., Anderson, A. M., Adekoya, O. O., Ajayi, O. O., Alabi, P. O., Okobi, O. E., Jaiyeola, O., & Ekanem, M. S. (2023) · Cureus · doi:10.7759/cureus.49930 · Cited by 27
The Behavior Rating Inventory of Executive Function (BRIEF) to Identify Pediatric Acute Lymphoblastic Leukemia (ALL) Survivors At Risk for Neurocognitive Impairment
Viola, A., Balsamo, L. M., Neglia, J. P., Brouwers, P. Y., Ma, X., & Kadan‐Lottick, N. S. (2017) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000000761 · Cited by 26
Self-citation
Neurocognitive Sequelae in Adult Childhood Leukemia Survivors Related to Levels of Phosphorylated Tau
Elens, I., Deprez, S., Danckaerts, M., Bijttebier, P., Labarque, V., Uyttebroeck, A., Gool, S. V., D’Hooge, R., & Lemiere, J. (2017) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djw321 · Cited by 26
Treatment for lymphoma and late cardiovascular disease risk: A systematic review and meta‐analysis
Stone, C. R., Mickle, A. T., Boyne, D. J., Mohamed, A., Rabi, D. M., Brenner, D. R., & Friedenreich, C. M. (2019) · Health Science Reports · doi:10.1002/hsr2.135 · Cited by 24
Longitudinal Trajectories of Neurocognitive Functioning in Childhood Acute Lymphoblastic Leukemia
Partanen, M., Phipps, S., Russell, K. M. W., Anghelescu, D. L., Wolf, J., Conklin, H. M., Krull, K. R., Inaba, H., Pui, C., & Jacola, L. M. (2020) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsaa086 · Cited by 24
The Role of the Central Nervous System Microenvironment in Pediatric Acute Lymphoblastic Leukemia
Gossai, N. P., & Gordon, P. M. (2017) · Frontiers in Pediatrics · doi:10.3389/fped.2017.00090 · Cited by 24
Neurocognitive impairment in Asian childhood cancer survivors: a systematic review
Peng, L., Yam, P. P.-Y., Yang, L. S., Sato, S., Li, C. K., & Cheung, Y. T. (2020) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09857-y · Cited by 24
Neuropsychological outcomes on Head Start III: a prospective, multi-institutional clinical trial for young children diagnosed with malignant brain tumors
O’Neil, S., Whitaker, A. M., Kayser, K., Nelson, M. B., Finlay, J. L., Dhall, G., & Sands, S. A. (2020) · Neuro-Oncology Practice · doi:10.1093/nop/npz071 · Cited by 22
Long-term neurocognitive and quality of life outcomes in survivors of pediatric hematopoietic cell transplant
Wu, N. L., Krull, K. R., Cushing‐Haugen, K. L., Ullrich, N. J., Kadan‐Lottick, N. S., Lee, S. J., & Chow, E. J. (2021) · Journal of Cancer Survivorship · doi:10.1007/s11764-021-01063-1 · Cited by 22
Self-citation
Quantitative MRI outcomes in child and adolescent leukemia survivors: Evidence for global alterations in gray and white matter
van der Plas, E. A. A., Noakes, L. S., Butcher, D. T., Weksberg, R., Galin-Corini, L., Wanstall, E. A., Te, P., Hopf, L., Guger, S., Spiegler, B. J., et al. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102428 · Cited by 23
A Review of Acute and Long-Term Neurological Complications Following Haematopoietic Stem Cell Transplant for Paediatric Acute Lymphoblastic Leukaemia
Gabriel, M. A., Hoeben, B. A. W., Uhlving, H. H., Zając‐Spychała, O., Lawitschka, Á., Bresters, D., & Ifversen, M. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.774853 · Cited by 23
Cognitive Impairment in Survivors of Adolescent and Early Young Adult Onset Non-CNS Cancers: Does Chemotherapy Play a Role?
John, T. D., Sender, L. S., & Bota, D. A. (2016) · Journal of Adolescent and Young Adult Oncology · doi:10.1089/jayao.2015.0025 · Cited by 22
Parental Considerations Regarding Cure and Late Effects for Children With Cancer
Greenzang, K. A., Al‐Sayegh, H., Ma, C., Najafzadeh, M., Wittenberg, E., & Mack, J. W. (2020) · PEDIATRICS · doi:10.1542/peds.2019-3552 · Cited by 23
The Mystery of Chemotherapy Brain: Kynurenines, Tubulin and Biophoton Release
Sordillo, P. P., & Sordillo, L. A. (2020) · Anticancer Research · doi:10.21873/anticanres.14061 · Cited by 21
Assessment of the effects of walking as an exercise intervention for children and adolescents with cancer: A feasibility study
Su, H., Wu, L., Chiou, S., Lin, P., & Liao, Y. (2018) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2018.10.006 · Cited by 20
Influence of genetic factors on long-term treatment related neurocognitive complications, and on anxiety and depression in survivors of childhood acute lymphoblastic leukemia: The Petale study
Petrykey, K., Lippé, S., Robaey, P., Sultan, S., Laniel, J., Drouin, S., Bertout, L., Beaulieu, P., St-Onge, P., Boulet‐Craig, A., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217314 · Cited by 23
DIVERGT screening procedure predicts general cognitive functioning in adult long‐term survivors of pediatric acute lymphoblastic leukemia: A PETALE study
Boulet‐Craig, A., Robaey, P., Laniel, J., Bertout, L., Drouin, S., Krajinović, M., Laverdière, C., Sinnett, D., Sultan, S., & Lippé, S. (2018) · Pediatric Blood & Cancer · doi:10.1002/pbc.27259 · Cited by 19
Social Functioning of Childhood Cancer Survivors after Computerized Cognitive Training: A Randomized Controlled Trial
Mendoza, L., Ashford, J. M., Willard, V. W., Clark, K. N., Martin-Elbahesh, K., Hardy, K. K., Merchant, T. E., Jeha, S., Wang, F., Zhang, H., et al. (2019) · Children · doi:10.3390/children6100105 · Cited by 18
Processing efficiency in pediatric cancer survivors: A review and operationalization for outcomes research and clinical utility
Trapani, J. A., & Murdaugh, D. L. (2022) · Brain and Behavior · doi:10.1002/brb3.2809 · Cited by 17
Effects of continuous wave and fractionated diode laser on human fibroblast cancer and dermal normal cells by zinc phthalocyanine in photodynamic therapy: A comparative study
Navaeipour, F., Afsharan, H., Tajalli, H., Mollabashi, M., Ranjbari, F., Montaseri, A., & Rashidi, M. (2016) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2016.06.017 · Cited by 18
The Cost of Cure: Chronic Conditions in Survivors of Child, Adolescent, and Young Adult Cancers
Signorelli, C., Fardell, J. E., Wakefield, C. E., Webber, K., & Cohn, R. J. (2016) · Springer eBooks · doi:10.1007/978-981-10-1844-2_13 · Cited by 18
Methotrexate Neurotoxicity Is Related to Epigenetic Modification of the Myelination Process
Chen, Y.-C. D., Sheen, J., Wang, S., Hsu, M., Hsiao, C., Chang, K., & Huang, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136718 · Cited by 18
Abnormal Development of Dendrites in Adult-Born Rat Hippocampal Granule Cells Induced by Cyclophosphamide
Wu, L., Guo, D., Liu, Q., Gao, F., Wang, X., Song, X., Wang, F., & Zhan, R. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00171 · Cited by 19
Maternal prenatal exposure to environmental factors and risk of childhood acute lymphocytic leukemia: A hospital-based case-control study in China
Wang, Y., Gao, P., Liang, G., Zhang, N., Wang, C., Wang, Y., Nie, L., Lv, X., Li, W., Guo, Q., et al. (2018) · Cancer Epidemiology · doi:10.1016/j.canep.2018.11.005 · Cited by 18
Neuropathic pain and neurocognitive functioning in children treated for acute lymphoblastic leukemia
Partanen, M., Alberts, N. M., Conklin, H. M., Krull, K. R., Pui, C., Anghelescu, D. L., & Jacola, L. M. (2021) · Pain · doi:10.1097/j.pain.0000000000002485 · Cited by 17
Cognitive outcomes among Latino survivors of childhood acute lymphoblastic leukemia and lymphoma: A cross‐sectional cohort study using culturally competent, performance‐based assessment
Bava, L., Johns, A. L., Kayser, K., & Freyer, D. R. (2017) · Pediatric Blood & Cancer · doi:10.1002/pbc.26844 · Cited by 17
White Matter Microstructure and Information Processing at the Completion of Chemotherapy-Only Treatment for Pediatric Acute Lymphoblastic Leukemia
Darling, S. J., Luca, C. D., Anderson, V. A., McCarthy, M., Hearps, S. J. C., & Seal, M. L. (2018) · Developmental Neuropsychology · doi:10.1080/87565641.2018.1473401 · Cited by 17
Motor function in survivors of pediatric acute lymphoblastic leukemia treated with chemotherapy-only.
Goebel, A., Koustenis, E., Rueckriegel, S., Pfuhlmann, L., Brandsma, R., Sival, D., Skarabis, H., Schuelke, M., & Driever, P. H. (2019) · European journal of paediatric neurology · doi:10.1016/j.ejpn.2018.12.005 · Cited by 16
Tailored education enhances healthy behaviour self‐efficacy in childhood cancer survivors: A randomised controlled study with a 4‐month follow‐up
Wu, L., Chen, C., Hsu, H., Liu, Y., & Su, H. (2019) · European Journal of Cancer Care · doi:10.1111/ecc.13063 · Cited by 15
Adaptive functioning and academic achievement in survivors of childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group
Jacola, L. M., Baran, J., Noll, R. B., Willard, V. W., Hardy, K. K., Embry, L. M., Hullmann, S. E., Larsen, E. C., Winick, N. J., & Kairalla, J. A. (2021) · Pediatric Blood & Cancer · doi:10.1002/pbc.28913 · Cited by 17
Long-term neuropsychological outcomes of survivors of young childhood brain tumors treated on the Head Start II protocol
Levitch, C. F., Malkin, B. D., Latella, L. E., Guerry, W. B., Gardner, S. L., Finlay, J. L., & Sands, S. A. (2021) · Neuro-Oncology Practice · doi:10.1093/nop/npab028 · Cited by 13
Chemobrain in blood cancers: How chemotherapeutics interfere with the brain's structure and functionality, immune system, and metabolic functions
Škurlová, M., Holubová, K., Kletečková, L., Kozák, T., Kubová, H., Horáček, J., & Valeš, K. (2023) · Medicinal Research Reviews · doi:10.1002/med.21977 · Cited by 14
A cross‐sectional follow‐up study of physical morbidities, neurocognitive function, and attention problems in post‐treatment childhood acute lymphoblastic leukemia survivors
Chiou, S., Lin, P., Liao, Y., & Yang, P. (2019) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.12061 · Cited by 12
Chronic Illnesses and Student Academic Performance
Thongseiratch, T., & Chandeying, N. (2020) · Journal of Health Science and Medical Research · doi:10.31584/jhsmr.2020738 · Cited by 17
Pregnancy outcomes in female childhood cancer survivors: Nationwide survey in Japan
Sekiguchi, M., Miyoshi, Y., Kikuchi, N., & Sago, H. (2017) · Pediatrics International · doi:10.1111/ped.13483 · Cited by 11
Childhood leukemia survivors exhibit deficiencies in sensory and cognitive processes, as reflected by event-related brain potentials after completion of curative chemotherapy: A preliminary investigation
Brace, K. M., Lee, W. W., Cole, P. D., & Sussman, E. S. (2019) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2019.1623865 · Cited by 11
Comparison of Neurocognitive Functioning and Fine Motor Skills in Pediatric Cancer Survivors and Healthy Children
Chipeeva, N., Deviaterikova, A. A., Glebova, E. V., Romanova, E. N., Karelin, A. F., & Kasatkin, V. N. (2022) · Cancers · doi:10.3390/cancers14235982 · Cited by 10
The Association Between Motor Skills and Academic Achievement Among Pediatric Survivors of Acute Lymphoblastic Leukemia
Balsamo, L. M., Sint, K., Neglia, J. P., Brouwers, P. Y., & Kadan‐Lottick, N. S. (2015) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsv103 · Cited by 10
Self-citation
Performance-based and parent ratings of attention in children treated for a brain tumor: The significance of radiation therapy and tumor location on outcome
Raghubar, K. P., Mahone, E. M., Yeates, K. O., & Ris, M. D. (2017) · Child Neuropsychology · doi:10.1080/09297049.2017.1280144 · Cited by 9
Brain morphology and information processing at the completion of chemotherapy-only treatment for pediatric acute lymphoblastic leukemia
Darling, S. J., Luca, C. R. D., Anderson, V. A., McCarthy, M., Hearps, S. J. C., & Seal, M. L. (2018) · Developmental Neurorehabilitation · doi:10.1080/17518423.2018.1492988 · Cited by 9
Targeted Therapy of Central Nervous System Acute Lymphoblastic Leukemia with an Integrin α6-Targeted Self-Assembling Proapoptotic Nanopeptide
Ye, J., Li, W., Chen, M., Shi, Q., Wang, H., Li, X.-L., Li, Y., Yang, J., Wang, Q.-L., Hu, F., et al. (2023) · Engineering · doi:10.1016/j.eng.2023.11.012 · Cited by 8
Insulin-like growth factor (IGF) signaling in T-cell acute lymphoblastic leukemia
Gusscott, S., Tamiro, F., Giambra, V., & Weng, A. P. (2019) · Advances in Biological Regulation · doi:10.1016/j.jbior.2019.100652 · Cited by 8
Translationally relevant mouse model of early life cancer and chemotherapy exposure results in brain and small intestine cytokine responses: A potential link to cognitive deficits
Konsman, J. P., Laaker, C. J., Lloyd, K. R., Hiltz, A. R., Smith, B. L., Smail, M. A., & Reyes, T. M. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.10.003 · Cited by 8
The Impact of Gut Microbiota Changes on Methotrexate-Induced Neurotoxicity in Developing Young Rats
Chen, Y.-C. D., Hou, C., Hsu, M., Huang, L., Hsiao, C., & Sheen, J. (2024) · Biomedicines · doi:10.3390/biomedicines12040908 · Cited by 9
Abnormal topological organization in white matter structural networks in survivors of acute lymphoblastic leukaemia with chemotherapy treatment
Zou, L., Su, L., Qi, R., Bao, F., Fang, X., Wang, L., Zhai, Z., Li, D., & Zheng, S. (2017) · Oncotarget · doi:10.18632/oncotarget.19104 · Cited by 8
The Working Memory Network and Its Association with Working Memory Performance in Survivors of non-CNS Childhood Cancer
Siegwart, V., Steiner, L., Pastore‐Wapp, M., Benzing, V., Spitzhüttl, J. S., Schmidt, M., Kiefer, C., Slavova, N., Grotzer, M. A., Roebers, C. M., et al. (2021) · Developmental Neuropsychology · doi:10.1080/87565641.2021.1922410 · Cited by 7
Early life cancer and chemotherapy lead to cognitive deficits related to alterations in microglial-associated gene expression in prefrontal cortex
Laaker, C. J., Cantelon, C., Davis, A. B., Lloyd, K. R., Agyeman, N., Hiltz, A. R., Smith, B. L., Konsman, J. P., & Reyes, T. M. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.07.009 · Cited by 7

Authors: Iyer, N. S., Balsamo, L. M., Bracken, M. B., & Kadan-Lottick, N. S.
Affiliations: Lake Erie College of Osteopathic Medicine (US)
Yale Cancer Center (US)
Yale University (US)
Pediatric Hematology/Oncology, Yale School of Medicine and Yale Cancer Center, New Haven, CT; and
ORCID: Iyer, Neel S.
Balsamo, Lyn M.
Kadan-Lottick, Nina S.
Venue: Blood
Publisher: American Society of Hematology
Published: 2015-07-16
Volume: 126
Issue: 3
Pages: 346-353
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2015-02-627414
OpenAlex: W1888049586
Cited by: 194
References: 66
Citations by year: 2026: 14 · 2025: 11 · 2024: 14 · 2023: 16 · 2022: 9 · 2021: 27 · 2020: 20 · 2019: 22 · 2018: 17 · 2017: 19 · 2016: 20 · 2015: 4
FWCI: 2.89
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Funders: St. Baldrick's Foundation
Topics: Health Sciences › Medicine › Hematology › Acute Lymphoblastic Leukemia research
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Keywords: childhood acute lymphoblastic leukemia, cognitive impairment, intelligence quotient, verbal IQ, performance IQ, working memory, processing speed, fine motor skills, cancer survivors
MeSH terms: Antineoplastic Combined Chemotherapy Protocols, Brain Neoplasms, Child, Cognition Disorders, Humans, Survival Rate, Survivors, Precursor Cell Lymphoblastic Leukemia-Lymphoma

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Chemotherapy-only treatment effects on long-term neurocognitive functioning in childhood ALL survivors: a review and meta-analysis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks