The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia
Open accessAbstract
Key Points: Telomerase gene therapy in a mouse model of aplastic anemia targets the bone marrow and provides increased and stable telomerase expression. Telomerase expression leads to telomere elongation and subsequently to the reversal of aplastic anemia phenotypes.
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“At least two mouse models have demonstrated a causative role of telomere dysfunction in bone marrow failure.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [85]
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“Similarly, transplantation of bone marrow from late-generation Tert-knockout mice in irradiated wild-type recipients resulted in aplastic anaemia85.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [85]
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“In both models, danazol or AAV-mediated Tert expression improved haematopoiesis85,86.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [85]
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“As an example, telomerase activation using a gene therapy strategy has shown therapeutic effects on mouse models of pulmonary fibrosis, and aplastic anemia 44,46 .”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [46]
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Citations
Cites
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Telomere measurement by quantitative PCR
Cawthon, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e47 · Cited by 3,550
Shelterin: the protein complex that shapes and safeguards human telomeres
de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056
Switching and Signaling at the Telomere
Blackburn, E. H. (2001) · Cell · doi:10.1016/s0092-8674(01)00492-5 · Cited by 2,139
Armanios, M., & Blackburn, E. H. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3246 · Cited by 982
Calado, R. T., & Young, N. S. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0903373 · Cited by 814
Inagaki, K., Fuess, S., Storm, T. A., Gibson, G. A., Mctiernan, C. F., Kay, M. A., & Nakai, H. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.03.014 · Cited by 610
Telomere and telomerase in stem cells
Hiyama, E., & Hiyama, K. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603671 · Cited by 573
Guidelines for the diagnosis and management of aplastic anaemia
Marsh, J. C. W., Ball, S. E., Cavenagh, J. D., Darbyshire, P. J., Dokal, I. S., Gordon‐Smith, E. C., Keidan, J., Laurie, A., Martín, A., Mercieca, J., et al. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07842.x · Cited by 557
Bernardes de Jesus, B., Vera, E., Schneeberger, K., Tejera, A. M., Ayuso, E., Bosch, F., & Blasco, M. A. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200245 · Cited by 548
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Items 101–116 of 116
Liu, X., Li, H., Guan, B., & Kong, D. (2024) · Research Square · doi:10.21203/rs.3.rs-4329016/v1
Gomes, W. R. (2024) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2024.tde-25072024-153611
Stern, J. L., Rizzardi, L. F., & Gassman, N. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.23.614488
Dyskeratosis congenita future: Hematopoietic stem cell transplantation or gene therapy?
Manoochehrabadi, S., Behfar, M., Ahmadvand, M., & Hamidieh, A. A. (2024) · Gene Reports · doi:10.1016/j.genrep.2024.102072
Ye, J., Fan, L., Bär, C., Thum, T., Plettenburg, O., Cox, R. J., & Zeilinger, C. (2025) · Scientific Reports · doi:10.1038/s41598-025-00230-z
Self-citationFeatures of the course of pregnancy in patients with aplastic anemia
Makarik, A. A., Lystsev, D., & Логутова, Л. С. (2025) · Russian Bulletin of Obstetrician-Gynecologist · doi:10.17116/rosakush20252505115
Tang, L., Li, D., Ma, Y., Cui, F., Wang, J., & Tian, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26637630
Tiendrébéogo, A. J. F. (2016) · theses.fr (ABES) · doi:10.70675/97c14c70z70b4z4788z8c7bzd0fb438c5895
Lemey, C. (2017) · theses.fr (ABES) · doi:10.70675/14dca0fcze537z4da0z9184z9b59c260ea88
Amélioration de la régénération cellulaire et tissulaire au cours du vieillissement
Alle, Q. (2020) · theses.fr (ABES) · doi:10.70675/932e617bzcb45z4332z8badzfda37d5299a8
Cross species activity of TERT human telomerase component
Sánchez-Vazquez, R., Paula, M., Saha, A., & Blasco, M. A. (2026) · Aging · doi:10.18632/aging.206372
Self-citationOverview of hallmarks of aging
Sangeeth, A., Subramanian, M., Singh, A., & Singh, A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33159-6.00004-7
Positioning TERT at the apex of aging
DePinho, R. A. (2026) · Nature Aging · doi:10.1038/s43587-026-01179-y
Mo, Q., Chen, L., Wu, Y., Chen, Z., Lin, F., Xiao, Y., & Liu, Z. (2026) · Stem Cells International · doi:10.1155/sci/2300675
Leukocyte telomere shortening in mice revisited
Pessoa, J., & de Jesus, B. B. (2026) · Discover Aging · doi:10.1007/s44518-026-00010-5
BindingDB (2024) · UC San Diego · doi:10.7270/q2mg7tw8
Metadata
- Authors
- Bär, C., Povedano, J. M., Serrano, R., Benitez-Buelga, C., Popkes, M., Formentini, I., Bobadilla, M., Bosch, F., & Blasco, M. A.
- Affiliations
- Telomeres and Telomerase Group, Molecular Oncology Program and
- Human Genetics Group, Spanish National Cancer Research Centre, Madrid, Spain;
- Roche Pharma Research and Early Development, Neuroscience, Ophthalmology, and Rare Disease, Roche Innovation Center and
- Roche Extending the Innovation Network Academia Partnering Program, F. Hoffmann-La Roche, Basel, Switzerland; and
- Centre of Animal Biotechnology and Gene Therapy, Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2016-04-07
- Volume
- 127
- Issue
- 14
- Pages
- 1770-1779
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2279382765
- Cited by
- 116
- References
- 42
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 23 · 2023: 14 · 2022: 10 · 2021: 8 · 2020: 6 · 2019: 12 · 2018: 11 · 2017: 8 · 2016: 2
- FWCI
- 8.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, other-oa)
- Funders
- Ministerio de Economía y Competitividad
- Fundación Botín
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Keywords
- aplastic anemia, telomerase reverse transcriptase, telomere shortening, AAV9, hematopoietic stem cells, bone marrow aplasia, pancytopenia, bone marrow hypoplasia
- MeSH terms
- Dependovirus, Anemia, Aplastic, Animals, Disease Models, Animal, Hematopoietic Stem Cells, Transduction, Genetic, Genetic Therapy, Telomere, Mice, Knockout, Telomerase, Mice, Telomere Homeostasis
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