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MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells
Abstract
Key Points: MOZ deletion in adult mice leads to a rapid loss of cells with HSC cell surface immuno-phenotype and transplantation ability. Absence of classically defined HSCs for an extended period does not substantially affect steady-state hematopoiesis.
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“While this is compatible with rare output of adult HSC compared to embryonic HSC14, the quantitative output of adult HSC is controversial 19–21.”
From Polylox barcoding reveals haematopoietic stem cell fates realized in vivo (2017) · cites this paper as [21]
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Cited by
Polylox barcoding reveals haematopoietic stem cell fates realized in vivo
Pei, W., Feyerabend, T. B., Rössler, J., Wang, X., Postrach, D., Busch, K., Rode, I., Klapproth, K., Dietlein, N., Quedenau, C., et al. (2017) · Nature · doi:10.1038/nature23653 · Cited by 443
The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing
Pucella, J. N., Upadhaya, S., & Reizis, B. (2020) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-020520-114601 · Cited by 53
Khokhar, E. S., Borikar, S., Eudy, E., Stearns, T., Young, K., & Trowbridge, J. J. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.01.014 · Cited by 26
Metadata
- Authors
- Sheikh, B. N., Yang, Y., Schreuder, J., Nilsson, S. K., Bilardi, R., Carotta, S., McRae, H. M., Metcalf, D., Voss, A. K., & Thomas, T.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2016-11-10
- Volume
- 128
- Issue
- 19
- Pages
- 2307-2318
- ISSN
- 0006-4971
- 1528-0020
- Cited by
- 98
- References
- 5
- Language
- en
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