Cited by 53Hematopoietic Stem Cell TransplantationBlood disorders and treatmentsMesenchymal stem cell research

The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing

Pucella, Joseph N., Upadhaya, Samik, Reizis, Boris·2020·Annual Review of Cell and Developmental Biology

Abstract

The generation of all blood cell lineages (hematopoiesis) is sustained throughout the entire life span of adult mammals. Studies using cell transplantation identified the self-renewing, multipotent hematopoietic stem cells (HSCs) as the source of hematopoiesis in adoptive hosts and delineated a hierarchy of HSC-derived progenitors that ultimately yield mature blood cells. However, much less is known about adult hematopoiesis as it occurs in native hosts, i.e., without transplantation. Here we review recent advances in our understanding of native hematopoiesis, focusing in particular on the application of genetic lineage tracing in mice. The emerging evidence has established HSCs as the major source of native hematopoiesis, helped to define the kinetics of HSC differentiation, and begun exploring native hematopoiesis in stress conditions such as aging and inflammation. Major outstanding questions about native hematopoiesis still remain, such as its clonal composition, the nature of lineage commitment, and the dynamics of the process in humans.

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Crossref · 10.1146/annurev-cellbio-020520-114601

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133 of 133 references verified0 citation errors · 0 not checkable

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  • At the current time, there is substantial evidence that HSCs make regular and consistent contributions to hematopoiesis.

    “At the current time, there is substantial evidence that HSCs make regular and consistent contributions to hematopoiesis, although further studies are needed to delineate the precise nature of these contributions, while accounting for limitations that exist for these different experimental approaches (Pucella et al., 2020).”

    From Unraveling Hematopoiesis through the Lens of Genomics (2020) · cites this paper as Pucella et al., 2020

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Authors
Pucella, J. N., Upadhaya, S., & Reizis, B.
Affiliations
New York University (US)
Venue
Annual Review of Cell and Developmental Biology
Published
2020-10-06
Volume
36
Issue
1
Pages
529-550
ISSN
  • 1081-0706 (ISSN-L)
  • 1530-8995
OpenAlex
W3037166030
Cited by
53
References
133
Citations by year
2026: 5 · 2025: 10 · 2024: 3 · 2023: 17 · 2022: 9 · 2021: 7 · 2020: 2
FWCI
1.37
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Cell and Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (R01AG049074)
  • National Heart, Lung, and Blood Institute (R21HL113678)
  • National Institute of Allergy and Infectious Diseases (R21AI128730, R21AI115382, R37AI072571)
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Keywords
adult hematopoiesis, hematopoietic stem cells, lineage tracing, HSC self-renewal, hematopoietic progenitor cells, aging, inflammation, clonal composition, lineage commitment, human hematopoiesis
MeSH terms
Adult, Aging, Cell Differentiation, Hematopoiesis, Hematopoietic Stem Cells, Humans, Kinetics, Cell Lineage

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