The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing
Abstract
The generation of all blood cell lineages (hematopoiesis) is sustained throughout the entire life span of adult mammals. Studies using cell transplantation identified the self-renewing, multipotent hematopoietic stem cells (HSCs) as the source of hematopoiesis in adoptive hosts and delineated a hierarchy of HSC-derived progenitors that ultimately yield mature blood cells. However, much less is known about adult hematopoiesis as it occurs in native hosts, i.e., without transplantation. Here we review recent advances in our understanding of native hematopoiesis, focusing in particular on the application of genetic lineage tracing in mice. The emerging evidence has established HSCs as the major source of native hematopoiesis, helped to define the kinetics of HSC differentiation, and begun exploring native hematopoiesis in stress conditions such as aging and inflammation. Major outstanding questions about native hematopoiesis still remain, such as its clonal composition, the nature of lineage commitment, and the dynamics of the process in humans.
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At the current time, there is substantial evidence that HSCs make regular and consistent contributions to hematopoiesis.
“At the current time, there is substantial evidence that HSCs make regular and consistent contributions to hematopoiesis, although further studies are needed to delineate the precise nature of these contributions, while accounting for limitations that exist for these different experimental approaches (Pucella et al., 2020).”
From Unraveling Hematopoiesis through the Lens of Genomics (2020) · cites this paper as Pucella et al., 2020
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- Authors
- Pucella, J. N., Upadhaya, S., & Reizis, B.
- Affiliations
- New York University (US)
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2020-10-06
- Volume
- 36
- Issue
- 1
- Pages
- 529-550
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W3037166030
- Semantic Scholar
- aefefe1c4354ea6ca825f59b323e89c2f918c023
- Cited by
- 53
- References
- 133
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 3 · 2023: 17 · 2022: 9 · 2021: 7 · 2020: 2
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG049074)
- National Heart, Lung, and Blood Institute (R21HL113678)
- National Institute of Allergy and Infectious Diseases (R21AI128730, R21AI115382, R37AI072571)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- adult hematopoiesis, hematopoietic stem cells, lineage tracing, HSC self-renewal, hematopoietic progenitor cells, aging, inflammation, clonal composition, lineage commitment, human hematopoiesis
- MeSH terms
- Adult, Aging, Cell Differentiation, Hematopoiesis, Hematopoietic Stem Cells, Humans, Kinetics, Cell Lineage
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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