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The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia

Rau, Rachel E., Rodriguez, Benjamin A., Luo, Min, Jeong, Mira, Rosen, Allison, Rogers, Jason H., Campbell, Carly T., Daigle, Scott R., Deng, Lishing, Song, Yongcheng, Sweet, Steve, Chevassut, Timothy, Andreeff, Michael, Kornblau, Steven M., Li, Wei, Goodell, Margaret A.·2016·Blood
DOI 10.1182/blood-2015-11-684225
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Abstract

Key Points: Data from Dnmt3a−/− mice implicate Dot1l as a critical mediator of the malignant gene expression program of Dnmt3a-mediated leukemia. Pharmacologic inhibition of DOT1L exerts potent antileukemic activity in DNMT3A-mutant human acute myeloid leukemia in vitro and in vivo.

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Citations

Cites

Show all 9 references

Research works printed but not linked: 30

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  2. Ribeiro, 2012, Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia., Blood, 119, 5824, 10.1182/blood-2011-07-367961 · DOI
  3. Yan, 2011, Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia., Nat Genet, 43, 309, 10.1038/ng.788 · DOI
  4. Kim, 2013, A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells., Blood, 122, 4086, 10.1182/blood-2013-02-483487 · DOI · Paper page
  5. Qu, 2014, Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes., Epigenetics, 9, 1108, 10.4161/epi.29315 · DOI
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  11. Noh, 2015, Engineering of a histone-recognition domain in Dnmt3a alters the epigenetic landscape and phenotypic features of mouse ESCs., Mol Cell, 59, 89, 10.1016/j.molcel.2015.05.017 · DOI
  12. Bernt, 2011, MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L., Cancer Cell, 20, 66, 10.1016/j.ccr.2011.06.010 · DOI
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  16. Anglin, 2012, Synthesis and structure-activity relationship investigation of adenosine-containing inhibitors of histone methyltransferase DOT1L., J Med Chem, 55, 8066, 10.1021/jm300917h · DOI
  17. Daigle, 2011, Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor., Cancer Cell, 20, 53, 10.1016/j.ccr.2011.06.009 · DOI
  18. Yao, 2011, Selective inhibitors of histone methyltransferase DOT1L: design, synthesis, and crystallographic studies., J Am Chem Soc, 133, 16746, 10.1021/ja206312b · DOI
  19. Liu, 2014, DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy., PLoS One, 9, e98270, 10.1371/journal.pone.0098270 · DOI
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  25. Grossmann, 2013, The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL., Genes Chromosomes Cancer, 52, 410, 10.1002/gcc.22039 · DOI
  26. Chang, 2010, Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes., Cancer Res, 70, 10234, 10.1158/0008-5472.CAN-10-3294 · DOI
  27. Sarkaria, 2014, Primary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro., Leukemia, 28, 2403, 10.1038/leu.2014.235 · DOI
  28. Spencer, 2015, Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells., Leukemia, 29, 1279, 10.1038/leu.2015.6 · DOI
  29. Alcalay, 2005, Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance., Blood, 106, 899, 10.1182/blood-2005-02-0560 · DOI
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Cited by

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Metadata

Authors
Rau, R. E., Rodriguez, B. A., Luo, M., Jeong, M., Rosen, A., Rogers, J. H., Campbell, C. T., Daigle, S. R., Deng, L., Song, Y., Sweet, S., Chevassut, T., Andreeff, M., Kornblau, S. M., Li, W., & Goodell, M. A.
Venue
Blood
Publisher
American Society of Hematology
Published
2016-08-18
Volume
128
Issue
7
Pages
971-981
ISSN
  • 0006-4971
  • 1528-0020
DOI
10.1182/blood-2015-11-684225
Cited by
122
References
9
Language
en

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CoChat. (2026). Citation check: DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia. https://app.cochat.ai/papers/10.1182/blood-2015-11-684225
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Rau, R. E., Rodriguez, B. A., Luo, M., Jeong, M., Rosen, A., Rogers, J. H., Campbell, C. T., Daigle, S. R., Deng, L., Song, Y., Sweet, S., Chevassut, T., Andreeff, M., Kornblau, S. M., Li, W., & Goodell, M. A. (2016). DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia. Blood. https://doi.org/10.1182/blood-2015-11-684225