Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2
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To the editor: Recent large-scale sequencing studies report recurrent somatic mutations in the blood of elderly individuals in genes previously linked to clonal expansion of hematopoietic stem cells.[1][1][⇓][2][⇓][3]-[4][4] Particularly for DNMT3A and TET2 , a steep age-associated increase in
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Many very old but healthy individuals have prominent clonal hematopoiesis without any signs of disease.
“in many perfectly healthy very aged individuals, prominent clonal hematopoiesis is present without any signs of disease.”
From Aging of hematopoietic stem cells (2018) · cites this paper as [81]
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Cites
Age-related clonal hematopoiesis associated with adverse outcomes
Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841 · see citing works
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
Genovese, G., Kähler, A. K., Handsaker, R. E., Lindberg, J., Rose, S. A., Bakhoum, S. F., Chambert, K., Mick, E., Neale, B. M., Fromer, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409405 · Cited by 3,531 · see citing works
COSMIC: exploring the world's knowledge of somatic mutations in human cancer
Forbes, S. A., Beare, D. M., Gunasekaran, P., Leung, K., Bindal, N., Boutselakis, H., Ding, M., Bamford, S., Cole, C. G., Ward, S. A., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1075 · Cited by 2,261 · see citing works
Age-related mutations associated with clonal hematopoietic expansion and malignancies
Xie, M., Lu, C., Wang, J., McLellan, M. D., Johnson, K. J., Wendl, M. C., McMichael, J. F., Schmidt, H. K., Yellapantula, V., Miller, C. A., et al. (2014) · Nature Medicine · doi:10.1038/nm.3733 · Cited by 1,874 · see citing works
The Rotterdam Study: objectives and design update
Albert Hofman, D., Breteler, M. M. B., van Duijn, C. M., Krestin, G. P., Pols, H. A. P., Stricker, B. H. C., Tiemeier, H. W., Uitterlinden, A. G., Vingerling, J. R., & Witteman, J. C. M. (2007) · European Journal of Epidemiology · doi:10.1007/s10654-007-9199-x · Cited by 1,404 · see citing works
Self-citationRecurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
Busque, L., Patel, J. P., Figueroa, M. E., Vasanthakumar, A., Provost, S., Hamilou, Z., Mollica, L., Li, J., Viale, A., Heguy, A., et al. (2012) · Nature Genetics · doi:10.1038/ng.2413 · Cited by 830 · see citing works
Schoenmaker, M., de Craen, A. J. M., de Meijer, P. H. E. M., Beekman, M., Blauw, G. J., Slagboom, P. E., & Westendorp, R. G. J. (2005) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201508 · Cited by 363 · see citing works
Self-citationThe Rotterdam Study: 2012 objectives and design update
Albert Hofman, D., van Duijn, C. M., Franco, O. H., Ikram, M. A., Janssen, H. L. A., Klaver, C. C. W., Kuipers, E. J., Nijsten, T. E. C., Stricker, B. H. C., Tiemeier, H. W., et al. (2011) · European Journal of Epidemiology · doi:10.1007/s10654-011-9610-5 · Cited by 289 · see citing works
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Research works printed but not linked: 9
- Haroche J, Arnaud L, Cohen-Aubart F, et al. Erdheim-Chester disease. Curr Rheumatol Rep. 2014;16(4):412.
- Aouba A, Georgin-Lavialle S, Pagnoux C, et al. Rationale and efficacy of interleukin-1 targeting in Erdheim-Chester disease. Blood. 2010;116(20): 4070-4076.
- Tran TA, Pariente D, Lecron JC, Delwail A, Taoufik Y, Meinzer U. Treatment of pediatric Erdheim-Chester disease with interleukin-1-targeting drugs. Arthritis Rheum. 2011;63(12):4031-4032.
- Aubert O, Aouba A, Deshayes S, Georgin-Lavialle S, Rieu P, Hermine O. Favorable radiological outcome of skeletal Erdheim-Chester disease involvement with anakinra. Joint Bone Spine. 2013;80(2):206-207.
- Killu AM, Liang JJ, Jaffe AS. Erdheim-Chester disease with cardiac involvement successfully treated with anakinra. Int J Cardiol. 2013;167(5):e115-e117.
- Courcoul A, Vignot E, Chapurlat R. Successful treatment of Erdheim-Chester disease by interleukin-1 receptor antagonist protein. Joint Bone Spine. 2014; 81(2):175-177.
- Darstein F, Kirschey S, Heckl S, et al. Successful treatment of Erdheim-Chester disease with combination of interleukin-1-targeting drugs and high-dose glucocorticoids. Intern Med J. 2014;44(1):90-92.
- Cohen PR, Kurzrock R. Anakinra-responsive lichen planus in a woman with Erdheim-Chester disease: a therapeutic enigma. Dermatol Online J. 2014; 20(1):21241.
- Diamond EL, Dagna L, Hyman DM, et al. Consensus guidelines for the diagnosis and clinical management of Erdheim-Chester disease. Blood. 2014; 124(4):483-492. References
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Self-citation
- Authors
- van den Akker, E. B., Pitts, S. J., Deelen, J., Moed, M. H., Potluri, S., van Rooij, J., Suchiman, H. E. D., Lakenberg, N., de Dijcker, W. J., Uitterlinden, A. G., Kraaij, R., Hofman, A., de Craen, A. J. M., Houwing-Duistermaat, J. J., van Ommen, G.-J. B., on behalf of the Genome of The Netherlands Consortium, Cox, D. R., van Meurs, J. B. J., Beekman, M., Reinders, M. J. T., & Slagboom, P. E.
- Affiliations
- Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands;
- Pfizer (United States) (US)
- Leiden University Medical Center (NL)
- Internal Medicine and
- Erasmus MC (NL)
- Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; and
- Gerontology and Geriatrics,
- Medical Statistics, and
- Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
- Delft University of Technology (NL)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2016-03-17
- Volume
- 127
- Issue
- 11
- Pages
- 1512-1515
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC4797027
- OpenAlex
- W2332549416
- Cited by
- 49
- References
- 8
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 10 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 2
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- VU Research Portal (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Funders
- Pfizer
- European Commission (FP7/2007-2011, FP7/2007, 259679)
- ZonMw (184.021.007, 050-060-810)
- Erasmus Medisch Centrum
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (184021007, 050.060.810, NWO 184.021.007)
- Medical Delta
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- DNMT3A, TET2, somatic mutations, oldest old, 10-year survival, germline mutations
- MeSH terms
- DNA Methyltransferase 3A, Aged, Aged, 80 and over, Aging, DNA, DNA (Cytosine-5-)-Methyltransferases, DNA-Binding Proteins, Female, Follow-Up Studies, Hematopoiesis, Humans, Longevity, Male, Mutation, Netherlands, Proto-Oncogene Proteins, Sequence Analysis, DNA, Dioxygenases
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