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The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

Basiorka, Ashley A., McGraw, Kathy L., Eksioglu, Erika A., Chen, Xianghong, Johnson, Joseph, Zhang, Ling, Zhang, Qing, Irvine, Brittany A., Cluzeau, Thomas, Sallman, David A., Padron, Eric, Komrokji, Rami, Sokol, Lubomir, Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Cleveland, John L., O’Neill, Luke A., Wei, Sheng, List, Alan F.·2016·Blood
DOI 10.1182/blood-2016-07-730556
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Abstract

Key Points: Key biological features of MDSs are explained by NLRP3 inflammasome activation, which drives pyroptotic cell death and β-catenin activation. Alarmin signals and founder gene mutations license this redox-sensitive inflammasome platform.

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Citations

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Research works printed but not linked: 50

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Cited by

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Metadata

Authors
Basiorka, A. A., McGraw, K. L., Eksioglu, E. A., Chen, X., Johnson, J., Zhang, L., Zhang, Q., Irvine, B. A., Cluzeau, T., Sallman, D. A., Padron, E., Komrokji, R., Sokol, L., Coll, R. C., Robertson, A. A. B., Cooper, M. A., Cleveland, J. L., O’Neill, L. A., Wei, S., & List, A. F.
Affiliations
  • Cancer Biology Ph.D. Program, Department of Malignant Hematology,
  • Department of Malignant Hematology,
  • Department of Immunology,
  • Analytic Microscopy Core Facility, and
  • Department of Hematopathology, H. Lee Moffitt Cancer Center, Tampa, FL;
  • Department of Hematology, Centre Hospitalier Universitaire de Nice, Nice, France;
  • Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia;
  • Department of Tumor Biology, H. Lee Moffitt Cancer Center, Tampa, FL; and
  • Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
Venue
Blood
Publisher
American Society of Hematology
Published
2016-12-22
Volume
128
Issue
25
Pages
2960-2975
ISSN
  • 0006-4971
  • 1528-0020
DOI
10.1182/blood-2016-07-730556
Cited by
348
References
12
Language
en

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