Polycomb repressive complexes in hematological malignancies

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

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The molecular hallmarks of epigenetic control

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.

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Clinical and biological implications of driver mutations in myelodysplastic syndromes

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EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

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Clinical Effect of Point Mutations in Myelodysplastic Syndromes

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The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

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Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

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Targeting EZH2 in cancer

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.

Lessard, J., & Sauvageau, G. (2003) · Nature · doi:10.1038/nature01572 · Cited by 1,452 · see citing works

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

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Acute myeloid leukemia ontogeny is defined by distinct somatic mutations

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EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

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PCGF Homologs, CBX Proteins, and RYBP Define Functionally Distinct PRC1 Family Complexes

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Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

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Identification of cooperating oncogenes in Eμ-myc transgenic mice by provirus tagging

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Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

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Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers

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Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer

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Genetic basis and molecular pathophysiology of classical myeloproliferative neoplasms

Vainchenker, W., & Královics, R. (2016) · Blood · doi:10.1182/blood-2016-10-695940 · Cited by 673 · see citing works

The role of mutations in epigenetic regulators in myeloid malignancies

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ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression

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SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition

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Polycomb group proteins: navigators of lineage pathways led astray in cancer

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EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

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Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

Ntziachristos, P., Tsirigos, A., Vlierberghe, P. V., Nedjic, J., Trimarchi, T., Flaherty, M. S., Ferrés-Marcó, D., Ros, V. G. D., Tang, Z., Siegle, J., et al. (2012) · Nature Medicine · doi:10.1038/nm.2651 · Cited by 528 · see citing works

Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1

Iwama, A., Oguro, H., Negishi, M., Kato, Y., Morita, Y., Tsukui, H., Ema, H., Kamijo, T., Katoh-Fukui, Y., Koseki, H., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.11.004 · Cited by 515 · see citing works

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

Raedt, T. D., Beert, E., Pasmant, É., Luscan, A., Brems, H., Ortonne, N., Helin, K., Hornick, J. L., Mautner, V., Kehrer‐Sawatzki, H., et al. (2014) · Nature · doi:10.1038/nature13561 · Cited by 463 · see citing works

Maintaining cell identity: PRC2-mediated regulation of transcription and cancer

Comet, I. V., Riising, E. M., Leblanc, B., & Helin, K. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.83 · Cited by 428 · see citing works

Dynamics of clonal evolution in myelodysplastic syndromes

Makishima, H., Yoshizato, T., Yoshida, K., Sekeres, M. A., Radivoyevitch, T., Suzuki, H., Przychodzen, B. P., Nagata, Y., Meggendorfer, M., Sanada, M., et al. (2016) · Nature Genetics · doi:10.1038/ng.3742 · Cited by 420 · see citing works

SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2

Kim, K. H., Kim, W., Howard, T. P., Vázquez, F., Tsherniak, A., Wu, J. N., Wang, W., Haswell, J. R., Walensky, L. D., Hahn, W. C., et al. (2015) · Nature Medicine · doi:10.1038/nm.3968 · Cited by 407 · see citing works

The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes

Huether, R., Dong, L., Chen, X. '., Wu, G., Parker, M. D., Wei, L., Ma, J., Edmonson, M. N., Hedlund, E., Rusch, M., et al. (2014) · Nature Communications · doi:10.1038/ncomms4630 · Cited by 378 · see citing works

The landscape of somatic mutations in Down syndrome–related myeloid disorders

Yoshida, K., Toki, T., Okuno, Y., Kanezaki, R., Shiraishi, Y., Sato‐Otsubo, A., Sanada, M., Park, M.-J., Terui, K., Suzuki, H., et al. (2013) · Nature Genetics · doi:10.1038/ng.2759 · Cited by 377 · see citing works

The polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion

Kamminga, L. M., Bystrykh, L. V., de Boer, A., Houwer, S., Douma, J., Weersing, E., Dontje, B., & de Haan, G. (2006) · Blood · doi:10.1182/blood-2005-09-3585 · Cited by 376 · see citing works

Targeting Polycomb systems to regulate gene expression: modifications to a complex story

Blackledge, N. P., Rose, N. R., & Klose, R. J. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4067 · Cited by 370 · see citing works

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

Ntziachristos, P., Tsirigos, A., Welstead, G. G., Trimarchi, T., Bakogianni, S., Xu, L., Loizou, E., Holmfeldt, L., Strikoudis, A., King, B., et al. (2014) · Nature · doi:10.1038/nature13605 · Cited by 366 · see citing works

Polycomb Group Protein Ezh2 Controls Actin Polymerization and Cell Signaling

Su, I.-H., Dobenecker, M.-W., Dickinson, E., Oser, M., Basavaraj, A., Marqueron, R., Viale, A., Reinberg, D., Wülfing, C., & Tarakhovsky, A. (2005) · Cell · doi:10.1016/j.cell.2005.02.029 · Cited by 365 · see citing works

Mutations of ASXL1 gene in myeloproliferative neoplasms

Carbuccia, N., Murati, A., Trouplin, V., Brecqueville, M., Adélaı̈de, J., Rey, J., Vainchenker, W., Bernard, O., Chaffanet, M., Vey, N., et al. (2009) · Leukemia · doi:10.1038/leu.2009.141 · Cited by 330 · see citing works

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo

Abdel-Wahab, O. I., Gao, J., Adli, M., Dey, A., Trimarchi, T., Chung, Y. R., Kuscu, C., Hricik, T., Ndiaye‐Lobry, D., LaFave, L. M., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20131141 · Cited by 322 · see citing works

Polycomb Repressive Complex 2 Regulates Normal Hematopoietic Stem Cell Function in a Developmental-Stage-Specific Manner

Xie, H., Xu, J., Hsu, J. H.-R., Nguyen, M., Fujiwara, Y., Peng, C., & Orkin, S. H. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.10.001 · Cited by 320 · see citing works

Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells

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BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas.

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A key role for <i>EZH2</i> and associated genes in mouse and human adult T-cell acute leukemia

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EZH2 mutational status predicts poor survival in myelofibrosis

Guglielmelli, P., Biamonte, F., Score, J., Hidalgo-Curtis, C., Cervantes, F., Maffioli, M., Fanelli, T., Ernst, T., Winkelman, N., Jones, A. V., et al. (2011) · Blood · doi:10.1182/blood-2011-06-363424 · Cited by 262 · see citing works

Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia

Göllner, S., Oellerich, T., Singh, S. A., Schenk, T., Klein, H., Rohde, C., Pabst, C., Sauer, T., Lerdrup, M., Tavor, S., et al. (2016) · Nature Medicine · doi:10.1038/nm.4247 · Cited by 257 · see citing works

EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors

Brainson, C. F., Xu, C., Desai, P. T., Berry, J. M., Rowbotham, S. P., Lin, Y.-J., Zhang, H., Márquez, V. E., Hammerman, P. S., Wong, K., et al. (2015) · Nature · doi:10.1038/nature14122 · Cited by 255 · see citing works

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis

Béguelin, W., Teater, M., Gearhart, M. D., Calvo Fernández, M. T., Goldstein, R. L., Cárdenas, M. G., Hatzi, K., Rosen, M., Shen, H., Corcoran, C. M., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.07.006 · Cited by 254 · see citing works

Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation

Klauke, K., Radulović, V., Broekhuis, M., Weersing, E., Zwart, E., Olthof, S., Ritsema, M., Bruggeman, S., Wu, X., Helin, K., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2701 · Cited by 237 · see citing works

Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9

Schneider, R. K., Schenone, M., Ferreira, M. S. V., Kramann, R., Joyce, C. E., Hartigan, C. R., Beier, F., Brümmendorf, T. H., Germing, U., Platzbecker, U., et al. (2016) · Nature Medicine · doi:10.1038/nm.4047 · Cited by 236 · see citing works

Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia

Xu, B., On, D. M., Ma, A., Parton, T., Konze, K. D., Pattenden, S. G., Allison, D. F., Cai, L., Rockowitz, S., Liu, S., et al. (2014) · Blood · doi:10.1182/blood-2014-06-581082 · Cited by 229 · see citing works

Polycomb repressive complex 2 is required for MLL-AF9 leukemia

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Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice

Oguro, H., Iwama, A., Morita, Y., Kamijo, T., van Lohuizen, M., & Nakauchi, H. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052477 · Cited by 227 · see citing works

Ezh1 Is Required for Hematopoietic Stem Cell Maintenance and Prevents Senescence-like Cell Cycle Arrest

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BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders

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An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation

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Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia.

Tanaka, S., Miyagi, S., Sashida, G., Chiba, T., Yuan, J., Mochizuki-Kashio, M., Suzuki, Y., Sugano, S., Nakaseko, C., Yokote, K., et al. (2012) · Blood · doi:10.1182/blood-2011-11-394932 · Cited by 201 · see citing works

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

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Juvenile myelomonocytic leukemia displays mutations in components of the RAS pathway and the PRC2 network

Caye‐Eude, A., Strullu, M., Guidez, F., Cassinat, B., Gazal, S., Fenneteau, O., Lainey, É., Nouri, K., Nakhaei‐Rad, S., Dvorský, R., et al. (2015) · Nature Genetics · doi:10.1038/ng.3420 · Cited by 190 · see citing works

Adult T-cell leukemia: molecular basis for clonal expansion and transformation of HTLV-1–infected T cells

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Poised Lineage Specification in Multipotential Hematopoietic Stem and Progenitor Cells by the Polycomb Protein Bmi1

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Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders

Muto, T., Sashida, G., Oshima, M., Wendt, G. R., Mochizuki‐Kashio, M., Nagata, Y., Sanada, M., Miyagi, S., Saraya, A., Kamio, A., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20131144 · Cited by 179 · see citing works

Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms

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Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation

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Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells

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Epigenetics of hematopoiesis and hematological malignanciesPreprint

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Developmental Control of Polycomb Subunit Composition by GATA Factors Mediates a Switch to Non-Canonical Functions

Xu, J., Shao, Z., Li, D., Xie, H., Kim, W., Huang, J., Taylor, J. E., Pinello, L., Glass, K., Jaffe, J. D., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2014.12.009 · Cited by 150 · see citing works

Epigenetic Reprogramming Sensitizes CML Stem Cells to Combined EZH2 and Tyrosine Kinase Inhibition

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Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner

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Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells

Majewski, I. J., Ritchie, M. E., Phipson, B., Corbin, J., Pakusch, M., Ebert, A., Busslinger, M., Koseki, H., Hu, Y., Smyth, G. K., et al. (2010) · Blood · doi:10.1182/blood-2009-12-260760 · Cited by 135 · see citing works

The polycomb group BMI1 gene is a molecular marker for predicting prognosis of chronic myeloid leukemia

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Multiple mechanisms deregulate EZH2 and histone H3 lysine 27 epigenetic changes in myeloid malignancies

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Bmi-1 is useful as a novel molecular marker for predicting progression of myelodysplastic syndrome and patient prognosis

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Polycomb Repressive Complex 2 (PRC2) Restricts Hematopoietic Stem Cell Activity

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UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemiaPreprint

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Loss of Ezh2 synergizes with JAK2 -V617F in initiating myeloproliferative neoplasms and promoting myelofibrosis

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