Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia
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Key Points: WT1 mRNA-electroporated DCs can prevent or delay relapse in 43% of patients with AML in remission after chemotherapy. OS compares favorably with the new survival data from the Swedish Acute Leukemia Registry and correlates with molecular and WT1-specific CD8+ T-cell responses.
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mRNA vaccines have shown good efficacy in the treatment of acute myelocytic leukemia (AML), non-small cell lung cancer (NSCLC), and melanoma.
“mRNA vaccines have shown good efficacy in the treatment of acute myelocytic leukemia (AML),339–341 non-small cell lung cancer (NSCLC),342,343 and melanoma344–348 (Table 3).”
From Advances in COVID-19 mRNA vaccine development (2022) · cites this paper as [340]
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- Haruo Sugiyama and Zwi N. Berneman Jorens, Herman Goossens, David A. Price, Kristin Ladell, Yoshihiro Oka, Fumihiro Fujiki, Yusuke Oji, Maes, Kathleen Deiteren, Ronald Malfait, Emma Gostick, Martin Lammens, Marie M. Couttenye, Philippe Verlinden, Alain P. Gadisseur, Wilfried A. Schroyens, Ludo Muylle, Katrien Vermeulen, Marie-Berthe Nathalie Cools, Griet Nijs, Barbara Stein, Eva Lion, Ann Van Driessche, Irma Vandenbosch, Anke Sébastien Anguille, Ann L. Van de Velde, Evelien L. Smits, Viggo F. Van Tendeloo, Gunnar Juliusson, relapse in acute myeloid leukemia Dendritic cell vaccination as post-remission treatment to prevent or delay http://www.bloodjournal.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://www.bloodjournal.org/site/misc/rights.xhtml#reprints Information about ordering reprints may be found online at: http://www.bloodjournal.org/site/subscriptions/index.xhtml Information about subscriptions and ASH membership may be found online at: digital object identifier (DOIs) and date of initial publication. by PubMed from initial publication. Citations to Advance online articles must include final publication). Advance online articles are citable and establish publication priority; they are appeared in the paper journal (edited, typeset versions by The American Society of Hematology; all rights reserved.
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- Authors
- Anguille, S., Van de Velde, A. L., Smits, E. L., Van Tendeloo, V. F., Juliusson, G., Cools, N., Nijs, G., Stein, B., Lion, E., Van Driessche, A., Vandenbosch, I., Verlinden, A., Gadisseur, A. P., Schroyens, W. A., Muylle, L., Vermeulen, K., Maes, M.-B., Deiteren, K., Malfait, R., Gostick, E., Lammens, M., Couttenye, M. M., Jorens, P., Goossens, H., Price, D. A., Ladell, K., Oka, Y., Fujiki, F., Oji, Y., Sugiyama, H., & Berneman, Z. N.
- Affiliations
- University of Antwerp (BE)
- Antwerp University Hospital, Antwerp, Belgium;
- Vaccine and Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium;
- Skåne University Hospital (SE)
- Antwerp University Hospital (BE)
- Department of Infection, Immunity and Biochemistry, Cardiff University School of Medicine, Cardiff, United Kingdom; and
- Cardiff University (GB)
- Department of Respiratory Medicine, Allergy & Rheumatic Diseases,
- Department of Cancer Immunology, and
- The University of Osaka (JP)
- Corresponding author
- Anguille, Sébastien
- Smits, Evelien L.
- Juliusson, Gunnar
- ORCID
- Anguille, Sébastien
- Smits, Evelien L.
- Juliusson, Gunnar
- Cools, Nathalie
- Lion, Eva
- Verlinden, Anke
- Gadisseur, Alain P.
- Schroyens, Wilfried A.
- Vermeulen, Katrien
- Maes, Marie-Berthe
- Deiteren, Kathleen
- Lammens, Martin
- Couttenye, Marie M.
- Jorens, Philippe
- Goossens, Herman
- Price, David A.
- Ladell, Kristin
- Fujiki, Fumihiro
- Oji, Yusuke
- Sugiyama, Haruo
- Berneman, Zwi N.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2017-10-12
- Volume
- 130
- Issue
- 15
- Pages
- 1713-1721
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC5649080
- OpenAlex
- W2747973325
- Cited by
- 230
- References
- 50
- Citations by year
- 2026: 13 · 2025: 23 · 2024: 25 · 2023: 29 · 2022: 30 · 2021: 35 · 2020: 29 · 2019: 26 · 2018: 19 · 2014: 1
- FWCI
- 9.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Wellcome Trust
- Japan Society for the Promotion of Science (15K09476, 17K07215)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Keywords
- dendritic cell vaccination, acute myeloid leukemia, post-remission therapy, relapse prevention, WT1 mRNA, electroporation, CD8+ T cell responses, overall survival, immunotherapy
- MeSH terms
- Aged, Dendritic Cells, Female, Humans, Male, Recurrence, Remission Induction, RNA, Messenger, Biomarkers, Tumor, Vaccination, Leukemia, Myeloid, Acute, Cytokines, Treatment Outcome, Electroporation, Disease-Free Survival, Cancer Vaccines, WT1 Proteins, Kaplan-Meier Estimate
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