Cited by 281Acute Myeloid Leukemia ResearchHematopoietic Stem Cell TransplantationBlood disorders and treatments

The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.

Age-related clonal hematopoiesis

Open access
Shlush, Liran I.·2018·Blood

Abstract

Age-related alterations in the human blood system occur in B cells, T cells, cells of the innate system, as well as hematopoietic stem and progenitor cells (HSPCs). Interestingly, age-related, reduced genetic diversity can be identified at the stem cell level and also independently in B cells and T cells. This reduced diversity is most probably related to somatic mutations or to changes in the microenvironmental niche. Either process can select for specific clones or cause repeated evolutionary bottlenecks. This review discusses the age-related clonal expansions in the human HSPC pool, which was termed in the past age-related clonal hematopoiesis (ARCH). ARCH is defined as the gradual, clonal expansion of HSPCs carrying specific, disruptive, and recurrent genetic variants, in individuals without clear diagnosis of hematological malignancies. ARCH is associated not just with chronological aging but also with several other, age-related pathological conditions, including inflammation, vascular diseases, cancer mortality, and high risk for hematological malignancies. Although it remains unclear whether ARCH is a marker of aging or plays an active role in these various pathophysiologies, it is suggested here that treating or even preventing ARCH may prove to be beneficial for human health. This review also describes a decision tree for the diagnosis and follow-up for ARCH in a research setting.

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Crossref · 10.1182/blood-2017-07-746453

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  1. Young, 2016, Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults, Nat Commun, 7, 12484, 10.1038/ncomms12484 · DOI · Paper page

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Metadata

Authors
Shlush, L. I.
Affiliations
Rambam Health Care Campus (IL)
Corresponding author
Shlush, Liran I.
Venue
Blood
Published
2018-02-01
Volume
131
Issue
5
Pages
496-504
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W2770273110
Cited by
281
References
66
Citations by year
2026: 17 · 2025: 27 · 2024: 20 · 2023: 27 · 2022: 31 · 2021: 48 · 2020: 46 · 2019: 43 · 2018: 22
FWCI
4.79
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Health Sciences › Medicine › Hematology › Blood disorders and treatments
Keywords
age-related clonal hematopoiesis, hematopoietic stem and progenitor cells, clonal expansion, somatic mutations, clonal evolution, hematological malignancy risk, inflammation, vascular disease, aging, B cells, T cells, hematopoietic niche
MeSH terms
Aging, Animals, Clone Cells, Hematopoiesis, Hematopoietic Stem Cells, Humans, Genetic Variation, Hematologic Neoplasms, Clonal Evolution

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