Age-related clonal hematopoiesis

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

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Age-related clonal hematopoiesis associated with adverse outcomes

Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

Genovese, G., Kähler, A. K., Handsaker, R. E., Lindberg, J., Rose, S. A., Bakhoum, S. F., Chambert, K., Mick, E., Neale, B. M., Fromer, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409405 · Cited by 3,531

Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease

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Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

Steensma, D. P., Bejar, R., Jaiswal, S., Lindsley, R. C., Sekeres, M. A., Hasserjian, R. P., & Ebert, B. L. (2015) · Blood · doi:10.1182/blood-2015-03-631747 · Cited by 1,971

Age-related mutations associated with clonal hematopoietic expansion and malignancies

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Mutation in TET2 in Myeloid Cancers

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The origin and evolution of mutations in acute myeloid leukemia

Welch, J. S., Ley, T. J., Link, D. C., Miller, C. A., Larson, D. E., Koboldt, D. C., Wartman, L. D., Lamprecht, T. L., Liu, F., Xia, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.023 · Cited by 1,575

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

Fuster, J. J., MacLauchlan, S., Zuriaga, M. A., Polackal, M. N., Ostriker, A. C., Chakraborty, R., Wu, C.-L., Sano, S., Muralidharan, S., Rius, C., et al. (2017) · Science · doi:10.1126/science.aag1381 · Cited by 1,536

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

Shlush, L. I., Zandi, S., Mitchell, A., Chen, W. C., Brandwein, J. M., Gupta, V., Kennedy, J. A., Schimmer, A. D., Schuh, A. C., Yee, K. W., et al. (2014) · Nature · doi:10.1038/nature13038 · Cited by 1,443

Pan-cancer analysis of whole genomes

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Liquid biopsy enters the clinic — implementation issues and future challenges

Ignatiadis, M., Sledge, G. W., & Jeffrey, S. S. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-00457-x · Cited by 1,191

Prediction of acute myeloid leukaemia risk in healthy individuals

Abelson, S., Collord, G., Ng, S. W. K., Weissbrod, O., Mendelson Cohen, N., Niemeyer, E., Barda, N., Zuzarte, P. C., Heisler, L., Sundaravadanam, Y., et al. (2018) · Nature · doi:10.1038/s41586-018-0317-6 · Cited by 850

Revised diagnostic criteria for neurofibromatosis type 1 and Legius syndrome: an international consensus recommendation

Legius, E., Messiaen, L. M., Wolkenstein, P., Pancza, P., Avery, R. A., Berman, Y. D., Blakeley, J. O., Babovic‐Vuksanovic, D., Cunha, K. S., Ferner, R. E., et al. (2021) · Genetics in Medicine · doi:10.1038/s41436-021-01170-5 · Cited by 834

Molecular Minimal Residual Disease in Acute Myeloid Leukemia

Jongen‐Lavrencic, M., Grob, T., Hanekamp, D., Kavelaars, F. G., Hinai, A. S. A. A., Zeilemaker, A., Erpelinck-Verschueren, C. A. J., Gradowska, P. L., Meijer, R. J., Cloos, J. J., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1716863 · Cited by 804

2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party

Heuser, M., Freeman, S. D., Ossenkoppele, G. J., Buccisano, F., Hourigan, C. S., Ngai, L. L., Tettero, J. M., Bachas, C., Baer, C. R., Béné, M. C., et al. (2021) · Blood · doi:10.1182/blood.2021013626 · Cited by 767

Brain immunology and immunotherapy in brain tumours

Sampson, J. H., Gunn, M. D., Fecci, P. E., & Ashley, D. M. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0224-7 · Cited by 758

Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6

Tyrrell, D. J., & Goldstein, D. R. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0431-7 · Cited by 447

Acute myeloid leukemia: 2019 update on risk‐stratification and management

Estey, E. H. (2018) · American Journal of Hematology · doi:10.1002/ajh.25214 · Cited by 374

Measurable residual disease monitoring by NGS before allogeneic hematopoietic cell transplantation in AML

Thol, F. R., Gabdoulline, R. R., Liebich, A., Klement, P., Schiller, J., Kandziora, C., Hambach, L., Stadler, M., Koenecke, C., Flintrop, M., et al. (2018) · Blood · doi:10.1182/blood-2018-02-829911 · Cited by 301

Clinical consequences of clonal hematopoiesis of indeterminate potential

Steensma, D. P. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018020222 · Cited by 194

Clinical consequences of clonal hematopoiesis of indeterminate potential

Steensma, D. P. (2018) · Hematology · doi:10.1182/asheducation-2018.1.264 · Cited by 189

Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction

Wang, Y., Sano, S., Yura, Y., Ke, Z., Sano, M., Oshima, K., Ogawa, H., Horitani, K., Min, K.-D., Miura-Yura, E., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.135204 · Cited by 167

Cardiovascular Disease, Aging, and Clonal Hematopoiesis

Evans, M. A., Sano, S., & Walsh, K. X. (2019) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012419-032544 · Cited by 169

Somatic Mutations and Clonal Hematopoiesis

Fuster, J. J., & Walsh, K. X. (2018) · Circulation Research · doi:10.1161/circresaha.117.312115 · Cited by 166

Molecular mechanisms of the preventable causes of cancer in the United StatesPreprint

Golemis, E. A., Scheet, P. A., Beck, T. N., Scolnick, E. M., Hunter, D. J., Hawk, E. T., & Hopkins, N. H. (2018) · Genes & Development · doi:10.1101/gad.314849.118 · Cited by 164

Laying the foundation for genomically-based risk assessment in chronic myeloid leukemia

on behalf of the International CML Foundation Genomics Alliance, Branford, S., Kim, D. D. H., Apperley, J. F., Eide, C. A., Mustjoki, S., Ong, S. T., Nteliopoulos, G., Ernst, T., Chuah, C., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0512-y · Cited by 149

Comorbid and inflammatory characteristics of genetic subtypes of clonal hematopoiesis

Cook, E. K., Izukawa, T., Young, S., Rosen, G., Jamali, M., Zhang, L., Johnson, D., Bain, E., Hilland, J., Ferrone, C. K., et al. (2019) · Blood Advances · doi:10.1182/bloodadvances.2018024729 · Cited by 153

Clonal dynamics in early human embryogenesis inferred from somatic mutation

Park, S., Mali, N. M., Kim, R., Choi, J., Lee, J., Lim, J., Park, J. M., Park, J. W., Kim, D., Kim, T., et al. (2021) · Nature · doi:10.1038/s41586-021-03786-8 · Cited by 146

Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis

Saiki, R., Momozawa, Y., Nannya, Y., Nakagawa, M. M., Ochi, Y., Yoshizato, T., Terao, C., Kuroda, Y., Shiraishi, Y., Chiba, K., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01411-9 · Cited by 143

Challenges and opportunities of cfDNA analysis implementation in clinical practice: Perspective of the International Society of Liquid Biopsy (ISLB)

Rolfo, C. D., Cardona, A. F., Cristofanilli, M., Paz-Ares, L. G., Díaz‐Mochon, J. J., Durán, I., Raez, L. E., Russo, A., Lorente, J. A., Malapelle, U., et al. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.102978 · Cited by 143

Granulopoiesis and Neutrophil Homeostasis: A Metabolic, Daily Balancing Act

Yvan‐Charvet, L., & Ng, L. G. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.05.004 · Cited by 137

Identification of Clonal Hematopoiesis Mutations in Solid Tumor Patients Undergoing Unpaired Next-Generation Sequencing Assays

Coombs, C. C., Gillis, N., Tan, X. M., Berg, J. S., Ball, M., Balasis, M. E., Montgomery, N. D., Bolton, K. L., Parker, J. S., Mesa, T., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1201 · Cited by 130

Losing Sense of Self and Surroundings: Hematopoietic Stem Cell Aging and Leukemic Transformation

Verovskaya, E. V., Dellorusso, P. V., & Passegue, E. A. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.04.006 · Cited by 130

Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss

Wang, H., Divaris, K., Pan, B., Li, X., Lim, J., Saha, G., Barovic, M., Giannakou, D., Korostoff, J. M., Bing, Y., et al. (2024) · Cell · doi:10.1016/j.cell.2024.05.003 · Cited by 122

Clonal hematopoiesis, somatic mosaicism, and age-associated disease

Evans, M. A., & Walsh, K. X. (2022) · Physiological Reviews · doi:10.1152/physrev.00004.2022 · Cited by 112

The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization

Takayama, N., Murison, A., Takayanagi, S., Arlidge, C., Zhou, S., García‐Prat, L., Chan‐Seng‐Yue, M., Zandi, S., Gan, O. I., Boutzen, H., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.11.001 · Cited by 101

Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway

Fujino, T., Goyama, S., Sugiura, Y., Inoue, D., Asada, S., Yamasaki, S., Matsumoto, A., Yamaguchi, K., Isobe, Y., Tsuchiya, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22053-y · Cited by 109

ICUS, IDUS, CHIP and CCUS: Diagnostic Criteria, Separation from MDS and Clinical Implications

Valent, P. (2018) · Pathobiology · doi:10.1159/000489042 · Cited by 102

New Insights from Studies of Clonal Hematopoiesis

Gibson, C. J., & Steensma, D. P. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-3044 · Cited by 97

Clinical, histopathological and molecular characterization of hypoplastic myelodysplastic syndrome

Bono, E. B., McLornan, D. P., Travaglino, E., Gandhi, S., Gallì, A., Khan, A. A., Kulasekararaj, A. G., Boveri, E., Raj, K. K., Elena, C., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0457-1 · Cited by 93

Are trade‐offs really the key drivers of ageing and life span?

Cohen, A. A., Coste, C. F. D., Li, X., Bourg, S., & Pavard, S. (2019) · Functional Ecology · doi:10.1111/1365-2435.13444 · Cited by 98

When Tissue is an Issue the Liquid Biopsy is Nonissue: A Review

Rodríguez, J. K., Ávila, J., Rolfo, C. D., Ruíz-Patiño, A., Russo, A., Ricaurte, L., Ordóñez‐Reyes, C., Arrieta, O. G., Zatarain-Barrón, Z. L., Recondo, G., et al. (2021) · Oncology and Therapy · doi:10.1007/s40487-021-00144-6 · Cited by 89

The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice

Yura, Y., Miura-Yura, E., Katanasaka, Y., Min, K.-D., Chavkin, N., Polizio, A. H., Ogawa, H., Horitani, K., Doviak, H., Evans, M. A., et al. (2021) · Circulation Research · doi:10.1161/circresaha.121.319314 · Cited by 87

Evolutionary landscape of clonal hematopoiesis in 3,359 individuals from the general population

van Zeventer, I. A., de Graaf, A. O., Salzbrunn, J. B., Nolte, I. M., Kamphuis, P., Dinmohamed, A. G., van der Reijden, B. A., Schuringa, J. J., Jansen, J. H., & Huls, G. A. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.04.006 · Cited by 85

Clonal Hematopoiesis of Indeterminate Potential Reshapes Age-Related CVD

Khetarpal, S. A., Qamar, A., Bick, A. G., Fuster, J. J., Kathiresan, S., Jaiswal, S., & Natarajan, P. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.05.045 · Cited by 88

Clinical exome sequencing—Mistakes and caveats

Corominas, J., Smeekens, S. P., Nelen, M. R., Yntema, H. G., Kamsteeg, E., Pfundt, R., & Gilissen, C. (2022) · Human Mutation · doi:10.1002/humu.24360 · Cited by 78

EASIX for prediction of survival in lower-risk myelodysplastic syndromes

Merz, A. M. A., Germing, U., Kobbe, G., Kaivers, J., Jauch, A. S., Radujkovic, A., Hummel, M., Benner, A., Merz, M., Dreger, P., et al. (2019) · Blood Cancer Journal · doi:10.1038/s41408-019-0247-z · Cited by 76

Liquid biopsy tracking of lung tumor evolutions over time

Russo, A., de Miguel‐Pérez, D., Gunasekaran, M., Scilla, K. A., Lapidus, R. S., Cooper, B., Mehra, R., Adamo, V., Malapelle, U., & Rolfo, C. D. (2019) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2020.1680287 · Cited by 76

Connections Between Clonal Hematopoiesis, Cardiovascular Disease, and Cancer

Arguelles, O. C., Jaiswal, S., Shlush, L. I., Moslehi, J. J., Schimmer, A. D., Barac, A., & Thavendiranathan, P. (2019) · JAMA Cardiology · doi:10.1001/jamacardio.2019.0302 · Cited by 73

Clinical Relevance of Clonal Hematopoiesis in the Oldest-Old Population

Rossi, M., Meggendorfer, M., Zampini, M., Tettamanti, M., Riva, E., Travaglino, E., Bersanelli, M., Mandelli, S., Galbussera, A. A., Mosca, E., et al. (2020) · Blood · doi:10.1182/blood.2021011320 · Cited by 73

Inflammatory signals from fatty bone marrow support DNMT3A driven clonal hematopoiesis

Zioni, N., Bercovich, A. A., Chapal-Ilani, N., Bacharach, T., Rappoport, N., Solomon, A., Avraham, R., Kopitman, E., Porat, Z., Sacma, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36906-1 · Cited by 67

Clonal Hematopoiesis: A New Step Linking Inflammation to Heart Failure

Yura, Y., Sano, S., & Walsh, K. X. (2020) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2019.08.006 · Cited by 69

Clonal hematopoiesis as a model for premalignant changes during aging

Steensma, D. P., & Ebert, B. L. (2019) · Experimental Hematology · doi:10.1016/j.exphem.2019.12.001 · Cited by 65

Assessing clonal haematopoiesis: clinical burdens and benefits of diagnosing myelodysplastic syndrome precursor states

Gondek, L. P., & Dezern, A. E. (2019) · The Lancet Haematology · doi:10.1016/s2352-3026(19)30211-x · Cited by 67

High prevalence of clonal hematopoiesis in the blood and bone marrow of healthy volunteers

Guermouche, H., Ravalet, N., Gallay, N., Deswarte, C., Foucault, A., Beaud, J., Rault, E., Saindoy, E., Lachot, S., Martignoles, J., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020001582 · Cited by 65

Validation of Lung EpiCheck, a novel methylation-based blood assay, for the detection of lung cancer in European and Chinese high-risk individuals

Gaga, M., Chorostowska‐Wynimko, J., Horváth, I., Tammemägi, M. C., Shitrit, D., Eisenberg, V. H., Liang, H., Stav, D., Faber, D. L., Jansen, M. A. M., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.02682-2020 · Cited by 61

Clonal Hematopoiesis: From Mechanisms to Clinical Intervention

Köhnke, T., & Majeti, R. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0901 · Cited by 63

Cardiovascular Disease Among Patients With AML and CHIP-Related Mutations

Arguelles, O. C., Schöffel, A. C., Capo‐Chichi, J., Abdel-Qadir, H. M., Schuh, A. C., Estrada, M. C., Liu, S., Gupta, V. K., Schimmer, A. D., Yee, K. W. L., et al. (2022) · JACC CardioOncology · doi:10.1016/j.jaccao.2021.11.008 · Cited by 60

Calcium regulation of stem cells

Snoeck, H. (2020) · EMBO Reports · doi:10.15252/embr.202050028 · Cited by 59

Spectrum of histiocytic neoplasms associated with diverse haematological malignancies bearing the same oncogenic mutation

Kemps, P. G., Hebeda, K. M., Pals, S. T., Verdijk, R. M., Lam, K. H., Bruggink, A. H., de Lil, H. S., Ruiterkamp, B., de Heer, K., van Laar, J. A. M., et al. (2020) · The Journal of Pathology Clinical Research · doi:10.1002/cjp2.177 · Cited by 57

The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing

Pucella, J. N., Upadhaya, S., & Reizis, B. (2020) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-020520-114601 · Cited by 53

Clonal hematopoiesis in elderly twins: concordance, discordance, and mortality

Hansen, J. W., Pedersen, D. A., Larsen, L. A., Husby, S., Clemmensen, S. B., Hjelmborg, J., Favero, F., Weischenfeldt, J., Christensen, K., & Grønbæk, K. (2019) · Blood · doi:10.1182/blood.2019001793 · Cited by 53

Next‐generation sequencing for measurable residual disease detection in acute myeloid leukaemia

Ghannam, J. Y., Dillon, L. W., & Hourigan, C. S. (2019) · British Journal of Haematology · doi:10.1111/bjh.16362 · Cited by 53

Low-level parental somatic mosaic SNVs in exomes from a large cohort of trios with diverse suspected Mendelian conditions

Gambin, T., Liu, Q., Karolak, J. A., Grochowski, C. M., Xie, N. G., Wu, L. R., Yan, Y. H., Cao, Y., Coban‐Akdemir, Z., Wilson, T. A., et al. (2020) · Genetics in Medicine · doi:10.1038/s41436-020-0897-z · Cited by 51

Is There a Causal Link Between Periodontitis and Cardiovascular Disease? A Concise Review of Recent Findings

Febbraio, M., Roy, C. B., & Levin, L. (2021) · International Dental Journal · doi:10.1016/j.identj.2021.07.006 · Cited by 55

Clonal haematopoiesis of indeterminate potential and cardiovascular events in systemic lupus erythematosus (HEMATOPLUS study)

David, C., Duployez, N., Eloy, P., Belhadi, D., Chezel, J., Guern, V. L., Laouenan, C., Fenwarth, L., Rouzaud, D., Mathian, A., et al. (2022) · Rheumatology · doi:10.1093/rheumatology/keac108 · Cited by 53

Atrial Fibrillation and Clonal Hematopoiesis in TET2 and ASXL1

Saadatagah, S., Naderian, M., Uddin, M. M., Dikilitas, O., Niroula, A., Schuermans, A., Selvin, E., Hoogeveen, R. C., Matsushita, K., Nambi, V., et al. (2024) · JAMA Cardiology · doi:10.1001/jamacardio.2024.0459 · Cited by 54

Diagnostic capabilities, clinical features, and longitudinal UBA1 clonal dynamics of a nationwide VEXAS cohort

Gurnari, C., Pascale, M. R., Vitale, A., Diral, E., Tomelleri, A., Galossi, E., Falconi, G., Bruno, A., Crisafulli, F., Frassi, M., et al. (2023) · American Journal of Hematology · doi:10.1002/ajh.27169 · Cited by 47

Clonal Hematopoiesis Risk Score and All-Cause and Cardiovascular Mortality in Older Adults

Saadatagah, S., Uddin, M. M., Weeks, L. D., Niroula, A., Ru, M., Takahashi, K., Gondek, L. P., Yu, B., Bick, A. G., Ebert, B. L., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.51927 · Cited by 45

Clonal hematopoiesis: Pre-cancer PLUS

Silver, A. J., & Jaiswal, S. (2019) · Advances in cancer research · doi:10.1016/bs.acr.2018.12.003 · Cited by 46

Mutations in normal tissues—some diagnostic and clinical implications

Fiala, C., & Diamandis, E. P. (2020) · BMC Medicine · doi:10.1186/s12916-020-01763-y · Cited by 42

Macrophages at the Crossroad of Meta-Inflammation and Inflammaging

Qu, L., Matz, A., Karlinsey, K. S., Cao, Z., Vella, A. T., & Zhou, B. (2022) · Genes · doi:10.3390/genes13112074 · Cited by 42

Bone marrow inflammatory memory in cardiometabolic disease and inflammatory comorbidities

Mitroulis, I., Hajishengallis, G., & Chavakis, T. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad003 · Cited by 42

Emerging Therapies for Acute Myelogenus Leukemia Patients Targeting Apoptosis and Mitochondrial Metabolism

Castelli, G., Pelosi, E., & Testa, U. (2019) · Cancers · doi:10.3390/cancers11020260 · Cited by 39

Calibration-free NGS quantitation of mutations below 0.01% VAF

Dai, P., Wu, L. R., Chen, S. X., Wang, M., Cheng, L. Y., Zhang, J. X., Hao, P., Yao, W., Zarka, J. G., Issa, G. C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26308-6 · Cited by 37

Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells

Sun, Y., Lin, X., Liu, B., Zhang, Y., Li, W., Zhang, S., He, F., Tian, H., Zhu, X., Liu, X., et al. (2021) · Science Advances · doi:10.1126/sciadv.abj6877 · Cited by 37

The Clinical Challenge of Idiopathic Cytopenias of Undetermined Significance (ICUS) and Clonal Cytopenias of Undetermined Significance (CCUS)

Steensma, D. P. (2019) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-019-00547-3 · Cited by 35

Monitoring of clonal evolution of acute myeloid leukemia identifies the leukemia subtype, clinical outcome and potential new drug targets for post-remission strategies or relapse

Onecha, E., Rapado, I., Morales, M. L., Carreño‐Tarragona, G., Martínez‐Sánchez, P., Gutiérrez, X., Pina, J. M. S., Linares, M., Gallardo, M., Martínez‐López, J., et al. (2020) · Haematologica · doi:10.3324/haematol.2020.254623 · Cited by 36

Updates on Old and Weary Haematopoiesis

Konieczny, J., & Arranz, L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092567 · Cited by 34

Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining

Feldman, T., Bercovich, A., Moskovitz, Y., Chapal-Ilani, N., Mitchell, A., Medeiros, J. J. F., Biezuner, T., Kaushansky, N., Minden, M. D., Gupta, V. K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22803-y · Cited by 34

Targeting Immunophenotypic Markers on Leukemic Stem Cells: How Lessons from Current Approaches and Advances in the Leukemia Stem Cell (LSC) Model Can Inform Better Strategies for Treating Acute Myeloid Leukemia (AML)Preprint

Mitchell, K., & Steidl, U. G. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a036251 · Cited by 37

Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice

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Role of TET dioxygenases in the regulation of both normal and pathological hematopoiesis

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Clonal hematopoiesis of indeterminate potential and the risk of autoimmune diseases

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Fate of Hematopoiesis During Aging. What Do We Really Know, and What are its Implications?

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Next-Generation Sequencing with Liquid Biopsies from Treatment-Naïve Non-Small Cell Lung Carcinoma Patients

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Translating Evidence from Clonal Hematopoiesis to Cardiovascular Disease: A Systematic Review

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Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age

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Detection of low-level parental somatic mosaicism for clinically relevant SNVs and indels identified in a large exome sequencing dataset

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Regulation of stress-induced hematopoiesis

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Somatic mosaicism detected by genome-wide sequencing in 500 parent–child trios with suspected genetic disease: clinical and genetic counseling implicationsPreprint

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Isocitrate Dehydrogenase Mutations in Myelodysplastic Syndromes and in Acute Myeloid Leukemias

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Patterns of mosaicism for sequence and copy-number variants discovered through clinical deep sequencing of disease-related genes in one million individuals

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Clonal Hematopoiesis and Its Cardiovascular Implications: A Scientific Statement From the American Heart Association

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Epigenetic Changes as a Target in Aging Haematopoietic Stem Cells and Age-Related Malignancies

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Somatic Mutations and Clonal Hematopoiesis as Drivers of Age-Related Cardiovascular Risk

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Mosaicism, aging and cancer

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Evolutionary trajectory of leukemic clones and its clinical implications

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Interplay of the heart, spleen, and bone marrow in heart failure: the role of splenic extramedullary hematopoiesis

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A novel machine-learning-derived genetic score correlates with measurable residual disease and is highly predictive of outcome in acute myeloid leukemia with mutated NPM1

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Relationship between Aging and Hematopoietic Cell Transplantation

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The potential of non-myeloablative heterochronous autologous hematopoietic stem cell transplantation for extending a healthy life span

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Combined landscape of single-nucleotide variants and copy-number alterations in clonal hematopoiesisPreprint

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Measurable Residual Disease Detection in Acute Myeloid Leukemia: Current Challenges and Future Directions

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Stem Cell Aging and Regenerative Medicine

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Acute myeloid leukaemia in patients we judge as being older and/or unfit

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Extracellular Vesicles and Hematopoietic Stem Cell Aging

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Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian

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Age-related somatic evolution of clonal haematopoiesis

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Clonal Hematopoiesis and Cytopenias in the Elderly

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Integrating clonal haematopoiesis into geriatric oncology: The ARCH between aging, cardiovascular disease and malignancy

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