Yin–Yang of costimulation: crucial controls of immune tolerance and function

Innate immune recognition

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Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

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A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

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Induced expression of PD‐1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

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PD-L2 is a second ligand for PD-1 and inhibits T cell activation

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Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

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B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

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IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

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Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

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IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

Korn, T., Bettelli, E., Gao, W., Awasthi, A., Jäger, A., Strom, T. B., Oukka, M., & Kuchroo, V. K. (2007) · Nature · doi:10.1038/nature05970 · Cited by 1,841 · see citing works

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

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Cancer regression and autoimmunity induced by cytotoxic t lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

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T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

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T cell anergy

Schwartz, R. H. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141110 · Cited by 1,487 · see citing works

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., & Kroczek, R. A. (1999) · Nature · doi:10.1038/16717 · Cited by 1,482 · see citing works

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

Nurieva, R., Yang, X. O., Martinez, G., Zhang, Y., Panopoulos, A. D., Ma, L., Schluns, K., Tian, Q., Watowich, S. S., Jetten, A. M., et al. (2007) · Nature · doi:10.1038/nature05969 · Cited by 1,466 · see citing works

Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production

Breitfeld, D., Ohl, L., Kremmer, E., Ellwart, J., Sallusto, F., Lipp, M., & Förster, R. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.11.1545 · Cited by 1,464 · see citing works

Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice

Nakae, S., Nambu, A., Sudo, K., & Iwakura, Y. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.6173 · Cited by 1,272 · see citing works

Tissue expression of PD-L1 mediates peripheral T cell tolerance

Keir, M., Liang, S. C., Guleria, I., Latchman, Y., Qipo, A., Albacker, L., Koulmanda, M., Freeman, G., Sayegh, M., & Sharpe, A. (2006) · Journal of Experimental Medicine · doi:10.1084/jem.20051776 · Cited by 1,264 · see citing works

Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function

Schaerli, P., Willimann, K., Lang, A. B., Lipp, M., Loetscher, P., & Moser, B. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.11.1553 · Cited by 1,263 · see citing works

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

Shahinian, A., Pfeffer, K., Lee, K. P., Kündig, T. M., Kishihara, K., Wakeham, A. C., Kawai, K., Ohashi, P. S., Thompson, C. B., & Mak, T. W. (1993) · Science · doi:10.1126/science.7688139 · Cited by 1,258 · see citing works

Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

Nurieva, R. I., Chung, Y., Hwang, D., Yang, X. O., Kang, H. S., Ma, L., Wang, Y.-H., Watowich, S. S., Jetten, A. M., Tian, Q., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.009 · Cited by 1,205 · see citing works

TH17 cells in development: an updated view of their molecular identity and genetic programming

Dong, C. (2008) · Nature reviews. Immunology · doi:10.1038/nri2295 · Cited by 1,064 · see citing works

Human IL-17: a novel cytokine derived from T cells

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B7-H3: A costimulatory molecule for T cell activation and IFN-γ production

Chapoval, A. I., Ni, J., Lau, J. S., Wilcox, R. A., Flies, D. B., Liu, D., Dong, H., Sica, G., Zhu, G., Tamada, K., et al. (2001) · Nature Immunology · doi:10.1038/85339 · Cited by 1,016 · see citing works

Expression of Programmed Death 1 Ligands by Murine T Cells and APC

Yamazaki, T., Akiba, H., Iwai, H., Matsuda, H., Aoki, M., Tanno, Y., Shin, T., Tsuchiya, H., Pardoll, D. M., Okumura, K., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.10.5538 · Cited by 950 · see citing works

ICOS co-stimulatory receptor is essential for T-cell activation and function

Dong, C., Juedes, A. E., Temann, U.-A., Shresta, S., Allison, J. P., Ruddle, N. H., & Flavell, R. A. (2001) · Nature · doi:10.1038/35051100 · Cited by 936 · see citing works

B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

Tseng, S.-Y., Otsuji, M., Gorski, K. S., Huang, X., Slansky, J. E., Pai, S. I., Shalabi, A., Shin, T., Pardoll, D. M., & Tsuchiya, H. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.7.839 · Cited by 867 · see citing works

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

Vinuesa, C. G., Cook, M. C., Angelucci, C., Athanasopoulos, V., Rui, L., Hill, K. M., Yu, D., Domaschenz, H., Whittle, B., Lambe, T., et al. (2005) · Nature · doi:10.1038/nature03555 · Cited by 862 · see citing works

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

Okazaki, T., Maeda, A., Nishimura, H., Kurosaki, T., & Honjo, T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231486598 · Cited by 849 · see citing works

The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

Ansari, M. J., Salama, A. D., Chitnis, T., Smith, R. N., Yagita∥, H., Akiba, H., Yamazaki, T., Azuma, M., Iwai, H., Khoury, S. J., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20022125 · Cited by 806 · see citing works

PD‐1 inhibits T‐cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ

Sheppard, K.-A., Fitz, L. J., Lee, J. M., Benander, C., George, J. A., Wooters, J., Qiu, Y., Jussif, J. M., Carter, L. L., Wood, C. R., et al. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.083 · Cited by 791 · see citing works

Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

Akbari, O., Freeman, G. J., Meyer, E. H., Greenfield, E. A., Chang, T. T., Sharpe, A. H., Berry, G. J., DeKruyff, R. H., & Umetsu, D. T. (2002) · Nature Medicine · doi:10.1038/nm745 · Cited by 791 · see citing works

T-cell co-stimulation through B7RP-1 and ICOS

Yoshinaga, S. K., Whoriskey, J. S., Khare, S. D., Sarmiento, U. M., Guo, J., Horan, T., Shih, G. C., Zhang, M., Coccia, M. A., Kohno, T., et al. (1999) · Nature · doi:10.1038/45582 · Cited by 775 · see citing works

B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

Kryczek, I., Zou, L., Rodriguez, P., Zhu, G., Wei, S., Mottram, P., Brumlik, M., Cheng, P., Curiel, T., Myers, L., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20050930 · Cited by 748 · see citing works

A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells

Vogelzang, A., McGuire, H. M., Yu, D., Sprent, J., Mackay, C. R., & King, C. (2008) · Immunity · doi:10.1016/j.immuni.2008.06.001 · Cited by 739 · see citing works

B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity

Sica, G., Choi, I.-H., Zhu, G., Tamada, K., Wang, S.-D., Tamura, H., Chapoval, A. I., Flies, D. B., Bajorath, J., & Chen, L. (2003) · Immunity · doi:10.1016/s1074-7613(03)00152-3 · Cited by 709 · see citing works

ICOS is essential for effective T-helper-cell responses

Tafuri, A., Shahinian, A., Bladt, F., Yoshinaga, S. K., Jordana, M., Wakeham, A. C., Boucher, L.-M., Bouchard, D., Chan, V. S. F., Duncan, G. S., et al. (2001) · Nature · doi:10.1038/35051113 · Cited by 674 · see citing works

Regulation of B Cell Differentiation and Plasma Cell Generation by IL-21, a Novel Inducer of Blimp-1 and Bcl-6

Ozaki, K., Spolski, R., Ettinger, R., Kim, H.-P., Wang, G., Qi, C.-F., Hwu, P., Shaffer, D. J., Akilesh, S., Roopenian, D. C., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.9.5361 · Cited by 668 · see citing works

ICOS is critical for CD40-mediated antibody class switching

McAdam, A. J., Greenwald, R. J., Levin, M. A., Chernova, T., Malenkovich, N., Ling, V., Freeman, G. J., & Sharpe, A. H. (2001) · Nature · doi:10.1038/35051107 · Cited by 644 · see citing works

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

Liang, S. C., Latchman, Y. E., Buhlmann, J. E., Tomczak, M. F., Horwitz, B. H., Freeman, G. J., & Sharpe, A. H. (2003) · European Journal of Immunology · doi:10.1002/eji.200324228 · Cited by 635 · see citing works

PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells

Loke, P., & Allison, J. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931259100 · Cited by 630 · see citing works

Follicular B helper T cells in antibody responses and autoimmunity

Vinuesa, C. G., Tangye, S. G., Moser, B., & Mackay, C. R. (2005) · Nature reviews. Immunology · doi:10.1038/nri1714 · Cited by 624 · see citing works

The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses

Suh, W.-K., Gajewska, B. U., Okada, H., Gronski, M. A., Bertram, E. M., Dawicki, W., Duncan, G. S., Bukczynski, J., Plyte, S., Elia, A., et al. (2003) · Nature Immunology · doi:10.1038/ni967 · Cited by 576 · see citing works

The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses

Coyle, A. J., Lehar, S. M., Lloyd, C. M., Tian, J. Y., Delaney, T. A., Manning, S., Nguyen, T., Burwell, T., Schneider, H., Gonzalo, J. A., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)00011-x · Cited by 519 · see citing works

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

Heissmeyer, V., Macián, F., Im, S., Varma, R., Feske, S., Venuprasad, K., Gu, H., Liu, Y., Dustin, M. L., & Rao, A. (2004) · Nature Immunology · doi:10.1038/ni1047 · Cited by 515 · see citing works

Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis

Salama, A. D., Chitnis, T., Imitola, J., Ansari, M. J., Akiba, H., Tushima, F., Azuma, M., Yagita∥, H., Sayegh, M. H., & Khoury, S. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20022119 · Cited by 501 · see citing works

B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation

Borriello, F., Sethna, M. P., Boyd, S. D., Schweitzer, A. N., Tivol, E. A., Jacoby, D., Strom, T. B., Simpson, E. M., Freeman, G. J., & Sharpe, A. H. (1997) · Immunity · doi:10.1016/s1074-7613(00)80333-7 · Cited by 498 · see citing works

Sarcoidosis is associated with a truncating splice site mutation in BTNL2

Valentonyte, R., Hampe, J., Huse, K., Rosenstiel, P. C., Albrecht, M., Stenzel, A., Nagy, M., Gaede, K. I., Franke, A., Häsler, R., et al. (2005) · Nature Genetics · doi:10.1038/ng1519 · Cited by 487 · see citing works

B7h, a Novel Costimulatory Homolog of B7.1 and B7.2, Is Induced by TNFα

Swallow, M. M., Wallin, J. J., & Sha, W. C. (1999) · Immunity · doi:10.1016/s1074-7613(00)80117-x · Cited by 453 · see citing works

CD4+CD25+ T Regulatory Cells Dependent on ICOS Promote Regulation of Effector Cells in the Prediabetic Lesion

Herman, A. E., Freeman, G. J., Mathis, D. J., & Benoist, C. O. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040179 · Cited by 450 · see citing works

Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation

Leonard, W. J., & Spolski, R. J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1688 · Cited by 439 · see citing works

Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells

McAdam, A. J., Chang, T. T., Lumelsky, A. E., Greenfield, E. A., Boussiotis, V. A., Duke‐Cohan, J. S., Chernova, T., Malenkovich, N., Jabs, C., Kuchroo, V. K., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.9.5035 · Cited by 439 · see citing works

Establishment of NOD- Pdcd1 -/- mice as an efficient animal model of type I diabetes

Wang, J., Yoshida, T., Nakaki, F., Hiai, H., Okazaki, T., & Honjo, T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505497102 · Cited by 436 · see citing works

B7S1, a Novel B7 Family Member that Negatively Regulates T Cell Activation

Prasad, D. V. R., Richards, S., Muoi, X., & Dong, C. (2003) · Immunity · doi:10.1016/s1074-7613(03)00147-x · Cited by 431 · see citing works

Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

Yu, D., Tan, A. H., Hu, X., Athanasopoulos, V., Simpson, N., Silva, D. G., Hutloff, A., Giles, K. M., Leedman, P. J., Lam, K., et al. (2007) · Nature · doi:10.1038/nature06253 · Cited by 414 · see citing works

B7x: A widely expressed B7 family member that inhibits T cell activation

Zang, X., Loke, P., Kim, J., MURPHY, K. M. M., Waitz, R., & Allison, J. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1434299100 · Cited by 401 · see citing works

IL-1-Independent Role of IL-17 in Synovial Inflammation and Joint Destruction During Collagen-Induced Arthritis

Lubberts, E., Joosten, L. A. B., Oppers‐Walgreen, B., van den Bersselaar, L., Roo, C. J. J. C., Kolls, J. K., Schwarzenberger, P. O., van de Loo, F. A. J., & van den Berg, W. B. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.2.1004 · Cited by 401 · see citing works

B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome

Zang, X., Thompson, R. H., Al-Ahmadie, H. A., Serio, A. M., Reuter, V. E., Eastham, J. A., Scardino, P. T., Sharma, P., & Allison, J. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709802104 · Cited by 401 · see citing works

ICOS Deficiency Is Associated with a Severe Reduction of CXCR5+CD4 Germinal Center Th Cells

Bossaller, L., Burger, J. A., Draeger, R., Grimbacher, B., Knoth, R., Plebani, A., Durandy, A., Baumann, U., Schlesier, M., Welcher, A. A., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4927 · Cited by 389 · see citing works

The Transcription Factor c-Maf Controls the Production of Interleukin-4 but Not Other Th2 Cytokines

Kim, J. I., Ho, I., Grusby, M. J., & Glimcher, L. H. (1999) · Immunity · doi:10.1016/s1074-7613(00)80073-4 · Cited by 383 · see citing works

Costimulatory regulation of T cell function

Chambers, C. A., & Allison, J. P. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80027-1 · Cited by 376 · see citing works

The Role of ICOS in the CXCR5+ Follicular B Helper T Cell Maintenance In Vivo

Akiba, H., Takeda, K., Kojima, Y., Usui, Y., Harada, N., Yamazaki, T., Ma, J., Tezuka, K., Yagita∥, H., & Okumura, K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2340 · Cited by 375 · see citing works

Murine B7-H3 is a negative regulator of T cells

Prasad, D. V. R., Nguyen, T., Li, Z., Yang, Y., Duong, J., Wang, Y., & Dong, C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.4.2500 · Cited by 368 · see citing works

Magnetic resonance imaging-determined synovial membrane volume as a marker of disease activity and a predictor of progressive joint destruction in the wrists of patients with rheumatoid arthritis

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B7-H4 expression in renal cell carcinoma and tumor vasculature: Associations with cancer progression and survival

Krambeck, A. E., Thompson, R. H., Dong, H., Lohse, C. M., Park, E. S., Kuntz, S. M., Leibovich, B. C., Blute, M. L., Cheville, J. C., & Kwon, E. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600937103 · Cited by 304 · see citing works

c-maf Promotes T Helper Cell Type 2 (Th2) and Attenuates Th1 Differentiation by Both Interleukin 4–dependent and –independent Mechanisms

Ho, I., Lo, D. D., & Glimcher, L. H. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.10.1859 · Cited by 303 · see citing works

Characterization of Mouse and Human B7-H3 Genes

Sun, M., Richards, S., Prasad, D. V. R., Mai, X. M., Rudensky, A. Y., & Dong, C. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.6294 · Cited by 295 · see citing works

Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells

Boyden, L. M., Lewis, J. M., Barbee, S. D., Bas, A., Girardi, M., Hayday, A., Tigelaar, R. E., & Lifton, R. P. (2008) · Nature Genetics · doi:10.1038/ng.108 · Cited by 288 · see citing works

Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 Interaction

Wang, S., Bajorath, J., Flies, D. B., Dong, H., Honjo, T., & Chen, L. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021752 · Cited by 288 · see citing works

Untitled work

Anandasabapathy (2003) · doi:10.1016/s1074-7613(03)00084-0 · Cited by 285 · see citing works

Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues

Ishida, M., Iwai, Y., Tanaka, Y., Okazaki, T., Freeman, G. J., Minato, N., & Honjo, T. (2002) · Immunology Letters · doi:10.1016/s0165-2478(02)00142-6 · Cited by 280 · see citing works

Cutting Edge: Induction of B7-H4 on APCs through IL-10: Novel Suppressive Mode for Regulatory T Cells

Kryczek, I., Wei, S., Zou, L., Zhu, G., Mottram, P. J., Xu, H., Chen, L., & Zou, W. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.40 · Cited by 278 · see citing works

Molecular Characterization of Human 4Ig-B7-H3, a Member of the B7 Family with Four Ig-Like Domains

Steinberger, P., Majdic, O., Derdak, S. V., Grabmeier‐Pfistershammer, K., Kirchberger, S., Klauser, C., Zlabinger, G. J., Pickl, W. F., Stöckl, J., & Knapp, W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2352 · Cited by 275 · see citing works

Blockade of the interleukin‐21/interleukin‐21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis

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Expression of ICOS In Vivo Defines CD4+ Effector T Cells with High Inflammatory Potential and a Strong Bias for Secretion of Interleukin 10

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